BDBM4281 2-[(4-methanesulfinylphenyl)methylidene]propanedinitrile::Tyrphostin deriv. 12::[4-(Methylsulfinyl)Benzylidene]malononitrile

SMILES: [#6]S(=O)c1ccc(\[#6]=[#6](/C#N)C#N)cc1

InChI Key: InChIKey=MVOSYVAMGLEZRZ-UHFFFAOYSA-N

Data: 1 IC50

Find this compound or compounds like it in BindingDB or PDB:

Substructure Similarity at least:  must be >=0.5 Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 1 hit for monomerid = 4281   

Target/Host (Institution)	Ligand	Target/Host Links	Ligand Links	Trg + Lig Links	Ki nM	ΔG° kcal/mole	IC50 nM	Kd nM	EC50/IC50 nM	koff s-1	kon M-1s-1	pH	Temp °C
Epidermal growth factor receptor (Homo sapiens (Human))	BDBM4281 (2-[(4-methanesulfinylphenyl)methylidene]propanedin...) Show SMILES [#6]S(=O)c1ccc(\[#6]=[#6](/C#N)C#N)cc1 Show InChI InChI=1S/C11H8N2OS/c1-15(14)11-4-2-9(3-5-11)6-10(7-12)8-13/h2-6H,1H3	PDB MMDB KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	1.80E+6	n/a	n/a	n/a	n/a	7.6	22
Hebrew University of Jerusalem					Assay Description The activity of EGFR, preactivated with EGF, is measured by its ability to transfer terminal phosphate from [gamma-32P]ATP to poly(GAT) substrate.				J Med Chem 34: 1896-907 (1991) Article DOI: 10.1021/jm00110a022 BindingDB Entry DOI: 10.7270/Q2KW5D7V
					More data for this Ligand-Target Pair