BDBM4282 2-(1H-indol-5-ylmethylidene)propanedinitrile::Tyrphostin deriv. 13

SMILES: N#CC(=Cc1ccc2[nH]ccc2c1)C#N

InChI Key: InChIKey=WXKRFPWLMFBHAV-UHFFFAOYSA-N

Data: 1 IC50

Find this compound or compounds like it in BindingDB or PDB:

Substructure Similarity at least:  must be >=0.5 Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 1 hit for monomerid = 4282   

Target/Host (Institution)	Ligand	Target/Host Links	Ligand Links	Trg + Lig Links	Ki nM	ΔG° kcal/mole	IC50 nM	Kd nM	EC50/IC50 nM	koff s-1	kon M-1s-1	pH	Temp °C
Epidermal growth factor receptor (Homo sapiens (Human))	BDBM4282 (2-(1H-indol-5-ylmethylidene)propanedinitrile | Tyr...) Show SMILES N#CC(=Cc1ccc2[nH]ccc2c1)C#N |(14.9,-11.28,;14.93,-9.6,;14.95,-7.91,;13.61,-7.16,;12.28,-7.94,;12.28,-9.48,;10.95,-10.25,;9.62,-9.48,;8.15,-9.96,;7.25,-8.71,;8.15,-7.47,;9.62,-7.94,;10.95,-7.17,;16.28,-7.12,;17.6,-6.34,)| Show InChI InChI=1S/C12H7N3/c13-7-10(8-14)5-9-1-2-12-11(6-9)3-4-15-12/h1-6,15H	PDB MMDB KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	Article PubMed	n/a	n/a	2.20E+6	n/a	n/a	n/a	n/a	7.6	22
Hebrew University of Jerusalem					Assay Description The activity of EGFR, preactivated with EGF, is measured by its ability to transfer terminal phosphate from [gamma-32P]ATP to poly(GAT) substrate.				J Med Chem 34: 1896-907 (1991) Article DOI: 10.1021/jm00110a022 BindingDB Entry DOI: 10.7270/Q2KW5D7V
					More data for this Ligand-Target Pair