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SMILES: CC(C)c1c([nH]c2ccc(nc12)N1CCN(C[C@@H]1C)C(=O)CN1CC2(COC2)C1)-c1cn2ncnc2c(C)c1C

InChI Key:

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 9 hits for monomerid = 428465   

Target/Host (Institution)	Ligand	Target/Host Links	Ligand Links	Trg + Lig Links	Ki nM	ΔG° kcal/mole	IC50 nM	Kd nM	EC50/IC50 nM	koff s-1	kon M-1s-1	pH	Temp °C
Toll-like receptor 7 (Homo sapiens (Human))	BDBM428465 (US10544143, Example 901 | US10730877, Example 901 ...) Show SMILES CC(C)c1c([nH]c2ccc(nc12)N1CCN(C[C@@H]1C)C(=O)CN1CC2(COC2)C1)-c1cn2ncnc2c(C)c1C |r| Show InChI	PDB UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	0.720	n/a	n/a	n/a	n/a	n/a	n/a
Bristol-Myers Squibb Company US Patent					Assay Description HEK-Blue-cells (Invivogen) overexpressing human TLR7, TLR8 or TLR9 receptors were used for screening inhibitors of these receptors using an inducible...				US Patent US10544143 (2020) BindingDB Entry DOI: 10.7270/Q2QF8W80
					More data for this Ligand-Target Pair
Toll-like receptor 8 (Homo sapiens (Human))	BDBM428465 (US10544143, Example 901 | US10730877, Example 901 ...) Show SMILES CC(C)c1c([nH]c2ccc(nc12)N1CCN(C[C@@H]1C)C(=O)CN1CC2(COC2)C1)-c1cn2ncnc2c(C)c1C |r| Show InChI	PDB UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	0.150	n/a	n/a	n/a	n/a	n/a	n/a
Bristol-Myers Squibb Company US Patent					Assay Description HEK-Blue-cells (Invivogen) overexpressing human TLR7, TLR8 or TLR9 receptors were used for screening inhibitors of these receptors using an inducible...				US Patent US10544143 (2020) BindingDB Entry DOI: 10.7270/Q2QF8W80
					More data for this Ligand-Target Pair
Toll-like receptor 9 (Homo sapiens (Human))	BDBM428465 (US10544143, Example 901 | US10730877, Example 901 ...) Show SMILES CC(C)c1c([nH]c2ccc(nc12)N1CCN(C[C@@H]1C)C(=O)CN1CC2(COC2)C1)-c1cn2ncnc2c(C)c1C |r| Show InChI	UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	1.33E+4	n/a	n/a	n/a	n/a	n/a	n/a
Bristol-Myers Squibb Company US Patent					Assay Description HEK-Blue-cells (Invivogen) overexpressing human TLR7, TLR8 or TLR9 receptors were used for screening inhibitors of these receptors using an inducible...				US Patent US10544143 (2020) BindingDB Entry DOI: 10.7270/Q2QF8W80
					More data for this Ligand-Target Pair
Toll-like receptor 7 (Homo sapiens (Human))	BDBM428465 (US10544143, Example 901 | US10730877, Example 901 ...) Show SMILES CC(C)c1c([nH]c2ccc(nc12)N1CCN(C[C@@H]1C)C(=O)CN1CC2(COC2)C1)-c1cn2ncnc2c(C)c1C |r| Show InChI	PDB UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	0.720	n/a	n/a	n/a	n/a	n/a	n/a
Bristol-Myers Squibb Company US Patent					Assay Description HEK-Blue-cells (Invivogen) overexpressing human TLR7, TLR8 or TLR9 receptors were used for screening inhibitors of these receptors using an inducible...				US Patent US10730877 (2020)
					More data for this Ligand-Target Pair
Toll-like receptor 9 (Homo sapiens (Human))	BDBM428465 (US10544143, Example 901 | US10730877, Example 901 ...) Show SMILES CC(C)c1c([nH]c2ccc(nc12)N1CCN(C[C@@H]1C)C(=O)CN1CC2(COC2)C1)-c1cn2ncnc2c(C)c1C |r| Show InChI	UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem		n/a	n/a	1.33E+4	n/a	n/a	n/a	n/a	n/a	n/a
TBA									Citation and Details
					More data for this Ligand-Target Pair
Toll-like receptor 9 (Homo sapiens (Human))	BDBM428465 (US10544143, Example 901 | US10730877, Example 901 ...) Show SMILES CC(C)c1c([nH]c2ccc(nc12)N1CCN(C[C@@H]1C)C(=O)CN1CC2(COC2)C1)-c1cn2ncnc2c(C)c1C |r| Show InChI	UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	1.33E+4	n/a	n/a	n/a	n/a	n/a	n/a
Bristol-Myers Squibb Company US Patent					Assay Description HEK-Blue-cells (Invivogen) overexpressing human TLR7, TLR8 or TLR9 receptors were used for screening inhibitors of these receptors using an inducible...				US Patent US10730877 (2020)
					More data for this Ligand-Target Pair
Toll-like receptor 7 (Homo sapiens (Human))	BDBM428465 (US10544143, Example 901 | US10730877, Example 901 ...) Show SMILES CC(C)c1c([nH]c2ccc(nc12)N1CCN(C[C@@H]1C)C(=O)CN1CC2(COC2)C1)-c1cn2ncnc2c(C)c1C |r| Show InChI	PDB UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem		n/a	n/a	0.720	n/a	n/a	n/a	n/a	n/a	n/a
TBA									Citation and Details
					More data for this Ligand-Target Pair
Toll-like receptor 8 (Homo sapiens (Human))	BDBM428465 (US10544143, Example 901 | US10730877, Example 901 ...) Show SMILES CC(C)c1c([nH]c2ccc(nc12)N1CCN(C[C@@H]1C)C(=O)CN1CC2(COC2)C1)-c1cn2ncnc2c(C)c1C |r| Show InChI	PDB UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem		n/a	n/a	0.150	n/a	n/a	n/a	n/a	n/a	n/a
TBA									Citation and Details
					More data for this Ligand-Target Pair
Toll-like receptor 8 (Homo sapiens (Human))	BDBM428465 (US10544143, Example 901 | US10730877, Example 901 ...) Show SMILES CC(C)c1c([nH]c2ccc(nc12)N1CCN(C[C@@H]1C)C(=O)CN1CC2(COC2)C1)-c1cn2ncnc2c(C)c1C |r| Show InChI	PDB UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	0.150	n/a	n/a	n/a	n/a	n/a	n/a
Bristol-Myers Squibb Company US Patent					Assay Description HEK-Blue-cells (Invivogen) overexpressing human TLR7, TLR8 or TLR9 receptors were used for screening inhibitors of these receptors using an inducible...				US Patent US10730877 (2020)
					More data for this Ligand-Target Pair