BDBM4288 (N-Methyl-5-hydroxy-2-oxo-3-indolinidene)malononitrile::2-(5-hydroxy-1-methyl-2-oxo-2,3-dihydro-1H-indol-3-ylidene)propanedinitrile::Tyrphostin deriv. 19
SMILES: [#6]-[#7]-1-[#6](=O)\[#6](=[#6](\C#N)C#N)-c2cc(-[#8])ccc-12
InChI Key: InChIKey=LTRIUTQNCXXORF-UHFFFAOYSA-N
Data: 1 IC50
Target/Host (Institution) | Ligand | Target/Host Links | Ligand Links | Trg + Lig Links | Ki nM | ΔG° kcal/mole | IC50 nM | Kd nM | EC50/IC50 nM | koff s-1 | kon M-1s-1 | pH | Temp °C |
---|---|---|---|---|---|---|---|---|---|---|---|---|---|
Epidermal growth factor receptor (Homo sapiens (Human)) | BDBM4288 ((N-Methyl-5-hydroxy-2-oxo-3-indolinidene)malononit...) | PDB MMDB KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet | PC cid PC sid UniChem Similars | Article PubMed | n/a | n/a | 2.60E+4 | n/a | n/a | n/a | n/a | n/a | n/a |
Hebrew University of Jerusalem | Assay Description The activity of EGFR, preactivated with EGF, is measured by its ability to transfer terminal phosphate from [gamma-32P]ATP to poly(GAT) substrate. | J Med Chem 34: 1896-907 (1991) Article DOI: 10.1021/jm00110a022 BindingDB Entry DOI: 10.7270/Q2KW5D7V | |||||||||||
More data for this Ligand-Target Pair |