BDBM4289 2-(5-nitro-2-oxo-2,3-dihydro-1H-indol-3-ylidene)propanedinitrile::Tyrphostin deriv. 20

SMILES: [#8-]-[#7+](=O)-c1ccc2-[#7]-[#6](=O)\[#6](=[#6](\C#N)C#N)-c2c1

InChI Key: InChIKey=ZMYPWDDPVIUWHA-UHFFFAOYSA-N

Data: 1 IC50

Find this compound or compounds like it in BindingDB or PDB:

Substructure Similarity at least:  must be >=0.5 Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 1 hit for monomerid = 4289   

Target/Host (Institution)	Ligand	Target/Host Links	Ligand Links	Trg + Lig Links	Ki nM	ΔG° kcal/mole	IC50 nM	Kd nM	EC50/IC50 nM	koff s-1	kon M-1s-1	pH	Temp °C
Epidermal growth factor receptor (Homo sapiens (Human))	BDBM4289 (2-(5-nitro-2-oxo-2,3-dihydro-1H-indol-3-ylidene)pr...) Show SMILES [#8-]-[#7+](=O)-c1ccc2-[#7]-[#6](=O)\[#6](=[#6](\C#N)C#N)-c2c1 Show InChI InChI=1S/C11H4N4O3/c12-4-6(5-13)10-8-3-7(15(17)18)1-2-9(8)14-11(10)16/h1-3H,(H,14,16)	PDB MMDB KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	Purchase PC cid PC sid UniChem	Article PubMed	n/a	n/a	4.00E+4	n/a	n/a	n/a	n/a	n/a	n/a
Hebrew University of Jerusalem					Assay Description The activity of EGFR, preactivated with EGF, is measured by its ability to transfer terminal phosphate from [gamma-32P]ATP to poly(GAT) substrate.				J Med Chem 34: 1896-907 (1991) Article DOI: 10.1021/jm00110a022 BindingDB Entry DOI: 10.7270/Q2KW5D7V
					More data for this Ligand-Target Pair