BDBM4290 (5-Methoxy-6-hydroxy-2-oxo-3-indolinidene)malononitrile::2-(6-hydroxy-5-methoxy-2-oxo-2,3-dihydro-1H-indol-3-ylidene)propanedinitrile::Tyrphostin deriv. 21

SMILES: [#6]-[#8]-c1cc2\[#6](=[#6](/C#N)C#N)-[#6](=O)-[#7]-c2cc1-[#8]

InChI Key: InChIKey=MAEZWIJGAMCORN-UHFFFAOYSA-N

Data: 2 IC50

Find this compound or compounds like it in BindingDB or PDB:

Substructure Similarity at least:  must be >=0.5 Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 2 hits for monomerid = 4290   

Target/Host (Institution)	Ligand	Target/Host Links	Ligand Links	Trg + Lig Links	Ki nM	ΔG° kcal/mole	IC50 nM	Kd nM	EC50/IC50 nM	koff s-1	kon M-1s-1	pH	Temp °C
Epidermal growth factor receptor (Homo sapiens (Human))	BDBM4290 ((5-Methoxy-6-hydroxy-2-oxo-3-indolinidene)malononi...) Show SMILES [#6]-[#8]-c1cc2\[#6](=[#6](/C#N)C#N)-[#6](=O)-[#7]-c2cc1-[#8] Show InChI InChI=1S/C12H7N3O3/c1-18-10-2-7-8(3-9(10)16)15-12(17)11(7)6(4-13)5-14/h2-3,16H,1H3,(H,15,17)	PDB MMDB KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	6	n/a	n/a	n/a	n/a	n/a	n/a
TBA Curated by ChEMBL					Assay Description Inhibition of EGFR in human A431 cells				J Nat Prod 55: 1529-1560 (1992) Article DOI: 10.1021/np50089a001 BindingDB Entry DOI: 10.7270/Q2J966CC
					More data for this Ligand-Target Pair
Epidermal growth factor receptor (Homo sapiens (Human))	BDBM4290 ((5-Methoxy-6-hydroxy-2-oxo-3-indolinidene)malononi...) Show SMILES [#6]-[#8]-c1cc2\[#6](=[#6](/C#N)C#N)-[#6](=O)-[#7]-c2cc1-[#8] Show InChI InChI=1S/C12H7N3O3/c1-18-10-2-7-8(3-9(10)16)15-12(17)11(7)6(4-13)5-14/h2-3,16H,1H3,(H,15,17)	PDB MMDB KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	6.00E+4	n/a	n/a	n/a	n/a	n/a	n/a
Hebrew University of Jerusalem					Assay Description The activity of EGFR, preactivated with EGF, is measured by its ability to transfer terminal phosphate from [gamma-32P]ATP to poly(GAT) substrate.				J Med Chem 34: 1896-907 (1991) Article DOI: 10.1021/jm00110a022 BindingDB Entry DOI: 10.7270/Q2KW5D7V
					More data for this Ligand-Target Pair