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BDBM429566 US10550089, Example 40::US10995072, Example 63

SMILES: CCc1coc2c(F)ccc(C(O)c3ncc[nH]3)c12

InChI Key:

Data: 6 IC50

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 6 hits for monomerid = 429566
Target/Host (Institution)	Ligand	Target/Host Links	Ligand Links	Trg + Lig Links	Ki nM	ΔG° kcal/mole	IC50 nM	Kd nM	EC50/IC50 nM	k_off s^-1	k_on M^-1s^-1	pH	Temp °C
Proteinase-activated receptor 2 (Homo sapiens (Human))	BDBM429566 (US10550089, Example 40 \| US10995072, Example 63) Show SMILES CCc1coc2c(F)ccc(C(O)c3ncc[nH]3)c12 Show InChI	PDB Reactome pathway KEGG UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	750	n/a	n/a	n/a	n/a	n/a	n/a
Heptares Therapeutics Limited US Patent					Assay Description Inositol monophosphate (IP1) production were measured in 1321N1 cells stably expressing human PAR2 using an IP-One HTRF assay kit (Cisbio). 80 nl of ...				US Patent US10550089 (2020) BindingDB Entry DOI: 10.7270/Q2SB484T
Heptares Therapeutics Limited US Patent					More data for this Ligand-Target Pair
Proteinase-activated receptor 2 (Homo sapiens (Human))	BDBM429566 (US10550089, Example 40 \| US10995072, Example 63) Show SMILES CCc1coc2c(F)ccc(C(O)c3ncc[nH]3)c12 Show InChI	PDB Reactome pathway KEGG UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	4.90E+3	n/a	n/a	n/a	n/a	n/a	n/a
Heptares Therapeutics Limited US Patent					Assay Description Calcium mobilization was measured using 1321N1 cells stably expressing human PAR2. Cells were seeded in 384-well plates at 4,000 cells per well in 20...				US Patent US10550089 (2020) BindingDB Entry DOI: 10.7270/Q2SB484T
Heptares Therapeutics Limited US Patent					More data for this Ligand-Target Pair
Proteinase-activated receptor 2 (Homo sapiens (Human))	BDBM429566 (US10550089, Example 40 \| US10995072, Example 63) Show SMILES CCc1coc2c(F)ccc(C(O)c3ncc[nH]3)c12 Show InChI	PDB Reactome pathway KEGG UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	1.56E+4	n/a	n/a	n/a	n/a	n/a	n/a
Heptares Therapeutics Limited US Patent					Assay Description Calcium mobilization was measured using 1321N1 cells stably expressing human PAR2. Cells were seeded in 384-well plates at 4,000 cells per well in 20...				US Patent US10995072 (2021)
Heptares Therapeutics Limited US Patent					More data for this Ligand-Target Pair
Proteinase-activated receptor 2 (Homo sapiens (Human))	BDBM429566 (US10550089, Example 40 \| US10995072, Example 63) Show SMILES CCc1coc2c(F)ccc(C(O)c3ncc[nH]3)c12 Show InChI	PDB Reactome pathway KEGG UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	4.90E+3	n/a	n/a	n/a	n/a	n/a	n/a
Heptares Therapeutics Limited US Patent					Assay Description Calcium mobilization was measured using 1321N1 cells stably expressing human PAR2. Cells were seeded in 384-well plates at 4,000 cells per well in 20...				US Patent US10995072 (2021)
Heptares Therapeutics Limited US Patent					More data for this Ligand-Target Pair
Proteinase-activated receptor 2 (Homo sapiens (Human))	BDBM429566 (US10550089, Example 40 \| US10995072, Example 63) Show SMILES CCc1coc2c(F)ccc(C(O)c3ncc[nH]3)c12 Show InChI	PDB Reactome pathway KEGG UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	1.23E+3	n/a	n/a	n/a	n/a	n/a	n/a
Heptares Therapeutics Limited US Patent					Assay Description Inositol monophosphate (IP1) production were measured in 1321N1 cells stably expressing human PAR2 using an IP-One HTRF assay kit (Cisbio). 80 nl of ...				US Patent US10995072 (2021)
Heptares Therapeutics Limited US Patent					More data for this Ligand-Target Pair
Proteinase-activated receptor 2 (Homo sapiens (Human))	BDBM429566 (US10550089, Example 40 \| US10995072, Example 63) Show SMILES CCc1coc2c(F)ccc(C(O)c3ncc[nH]3)c12 Show InChI	PDB Reactome pathway KEGG UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	750	n/a	n/a	n/a	n/a	n/a	n/a
Heptares Therapeutics Limited US Patent					Assay Description Inositol monophosphate (IP1) production were measured in 1321N1 cells stably expressing human PAR2 using an IP-One HTRF assay kit (Cisbio). 80 nl of ...				US Patent US10995072 (2021)
Heptares Therapeutics Limited US Patent					More data for this Ligand-Target Pair