BDBM430034 US10538528, Compound 16
SMILES: COc1cc(c(F)cn1)-c1ccc(NCCN2CCCC2)c(n1)C1CCN(CC1)c1ncnc2NC(=O)C(C)c12
InChI Key: InChIKey=NNEGEHDJOHHIGP-UHFFFAOYSA-N
Data: 3 IC50
Target/Host (Institution) | Ligand | Target/Host Links | Ligand Links | Trg + Lig Links | Ki nM | ΔG° kcal/mole | IC50 nM | Kd nM | EC50/IC50 nM | koff s-1 | kon M-1s-1 | pH | Temp °C |
---|---|---|---|---|---|---|---|---|---|---|---|---|---|
Ribosomal protein S6 kinase alpha-1 (Homo sapiens (Human)) | BDBM430034 (US10538528, Compound 16) | PDB MMDB NCI pathway Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet | UniChem | US Patent | n/a | n/a | 1.90 | n/a | n/a | n/a | n/a | n/a | n/a |
Taiho Pahrmaceutical Co., Ltd. US Patent | Assay Description Akt1 was prepared and assays of inhibitory activity of the compound according to the present invention against Akt1 kinase activity in vitro were con... | US Patent US10538528 (2020) BindingDB Entry DOI: 10.7270/Q2MK6G95 | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
RAC-alpha serine/threonine-protein kinase (Homo sapiens (Human)) | BDBM430034 (US10538528, Compound 16) | PDB UniProtKB/SwissProt UniProtKB/TrEMBL antibodypedia GoogleScholar AffyNet | UniChem | US Patent | n/a | n/a | 0.700 | n/a | n/a | n/a | n/a | n/a | n/a |
Taiho Pahrmaceutical Co., Ltd. US Patent | Assay Description S6K1: Inhibitory activity of the compound according to the present invention on S6K1 kinase activity in vitro was assayed using the QSS Assist FP ass... | US Patent US10538528 (2020) BindingDB Entry DOI: 10.7270/Q2MK6G95 | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Ryanodine receptor 1 [4317-4329] () | BDBM430034 (US10538528, Compound 16) | GoogleScholar AffyNet | UniChem | US Patent | n/a | n/a | 0.800 | n/a | n/a | n/a | n/a | n/a | n/a |
Taiho Pahrmaceutical Co., Ltd. US Patent | Assay Description Rsk1: Inhibitory activity of the compound according to the present invention on Rsk1 kinase activity in vitro was assayed using the QSS Assist FP ass... | US Patent US10538528 (2020) BindingDB Entry DOI: 10.7270/Q2MK6G95 | |||||||||||
More data for this Ligand-Target Pair |