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SMILES: CC1C(=O)Nc2ncnc(N3CCC(CC3)c3nc(ccc3NCCN3CCCC3)-c3ncco3)c12

InChI Key: InChIKey=QSTCFOHPMVKXGZ-UHFFFAOYSA-N

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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 1 hit for monomerid = 430043   
Target/Host
(Institution)		LigandTarget/Host
Links		Ligand
Links		Trg + Lig
Links		Ki
nM		ΔG°
kcal/mole		IC50
nM		Kd
nM		EC50/IC50
nM		koff
s-1		kon
M-1s-1		pHTemp
°C
Ribosomal protein S6 kinase alpha-1


(Homo sapiens (Human))		BDBM430043
PNG
(US10538528, Compound 25)
Show SMILES CC1C(=O)Nc2ncnc(N3CCC(CC3)c3nc(ccc3NCCN3CCCC3)-c3ncco3)c12
Show InChI InChI=1S/C26H32N8O2/c1-17-21-23(32-25(17)35)29-16-30-24(21)34-12-6-18(7-13-34)22-19(27-8-14-33-10-2-3-11-33)4-5-20(31-22)26-28-9-15-36-26/h4-5,9,15-18,27H,2-3,6-8,10-14H2,1H3,(H,29,30,32,35)
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MMDB

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KEGG

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US Patent
n/an/a 2.70n/an/an/an/an/an/a



Taiho Pahrmaceutical Co., Ltd.

US Patent


Assay Description
Akt1 was prepared and assays of inhibitory activity of the compound according to the present invention against Akt1 kinase activity in vitro were con...

US Patent US10538528 (2020)


BindingDB Entry DOI: 10.7270/Q2MK6G95
More data for this
Ligand-Target Pair