BDBM430044 US10538528, Compound 27

SMILES: CC1C(=O)Nc2ncnc(N3CCC(CC3)c3cc(cnc3NCCN3CCCC3)-c3cc(nn3C)C(F)(F)F)c12

InChI Key: InChIKey=PCZMIWZARLASMT-UHFFFAOYSA-N

Data: 2 IC50

Find this compound or compounds like it in BindingDB or PDB:

Substructure Similarity at least:  must be >=0.5 Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 2 hits for monomerid = 430044   

Target/Host (Institution)	Ligand	Target/Host Links	Ligand Links	Trg + Lig Links	Ki nM	ΔG° kcal/mole	IC50 nM	Kd nM	EC50/IC50 nM	koff s-1	kon M-1s-1	pH	Temp °C
Ryanodine receptor 1 [4317-4329] ()	BDBM430044 (US10538528, Compound 27) Show SMILES CC1C(=O)Nc2ncnc(N3CCC(CC3)c3cc(cnc3NCCN3CCCC3)-c3cc(nn3C)C(F)(F)F)c12 Show InChI InChI=1S/C28H34F3N9O/c1-17-23-25(36-27(17)41)34-16-35-26(23)40-10-5-18(6-11-40)20-13-19(21-14-22(28(29,30)31)37-38(21)2)15-33-24(20)32-7-12-39-8-3-4-9-39/h13-18H,3-12H2,1-2H3,(H,32,33)(H,34,35,36,41)	GoogleScholar AffyNet	UniChem	US Patent	n/a	n/a	1.80	n/a	n/a	n/a	n/a	n/a	n/a
Taiho Pahrmaceutical Co., Ltd. US Patent					Assay Description Rsk1: Inhibitory activity of the compound according to the present invention on Rsk1 kinase activity in vitro was assayed using the QSS Assist FP ass...				US Patent US10538528 (2020) BindingDB Entry DOI: 10.7270/Q2MK6G95
					More data for this Ligand-Target Pair
Ribosomal protein S6 kinase alpha-1 (Homo sapiens (Human))	BDBM430044 (US10538528, Compound 27) Show SMILES CC1C(=O)Nc2ncnc(N3CCC(CC3)c3cc(cnc3NCCN3CCCC3)-c3cc(nn3C)C(F)(F)F)c12 Show InChI InChI=1S/C28H34F3N9O/c1-17-23-25(36-27(17)41)34-16-35-26(23)40-10-5-18(6-11-40)20-13-19(21-14-22(28(29,30)31)37-38(21)2)15-33-24(20)32-7-12-39-8-3-4-9-39/h13-18H,3-12H2,1-2H3,(H,32,33)(H,34,35,36,41)	PDB MMDB NCI pathway Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	UniChem	US Patent	n/a	n/a	1.60	n/a	n/a	n/a	n/a	n/a	n/a
Taiho Pahrmaceutical Co., Ltd. US Patent					Assay Description Akt1 was prepared and assays of inhibitory activity of the compound according to the present invention against Akt1 kinase activity in vitro were con...				US Patent US10538528 (2020) BindingDB Entry DOI: 10.7270/Q2MK6G95
					More data for this Ligand-Target Pair