BDBM4311 (2E)-2-cyano-3-(3,4-dihydroxyphenyl)-N-[2-(3,4-dimethoxyphenyl)ethyl]prop-2-enamide::Tyrphostin deriv. 62

SMILES: COc1ccc(CCNC(=O)C(=C\c2ccc(O)c(O)c2)\C#N)cc1OC

InChI Key: InChIKey=SPPRJVVDZRWCNP-OQLLNIDSSA-N

Data: 1 IC50

Find this compound or compounds like it in BindingDB or PDB:

Substructure Similarity at least:  must be >=0.5 Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 1 hit for monomerid = 4311   

Target/Host (Institution)	Ligand	Target/Host Links	Ligand Links	Trg + Lig Links	Ki nM	ΔG° kcal/mole	IC50 nM	Kd nM	EC50/IC50 nM	koff s-1	kon M-1s-1	pH	Temp °C
Epidermal growth factor receptor (Homo sapiens (Human))	BDBM4311 ((2E)-2-cyano-3-(3,4-dihydroxyphenyl)-N-[2-(3,4-dim...) Show SMILES COc1ccc(CCNC(=O)C(=C\c2ccc(O)c(O)c2)\C#N)cc1OC Show InChI InChI=1S/C20H20N2O5/c1-26-18-6-4-13(11-19(18)27-2)7-8-22-20(25)15(12-21)9-14-3-5-16(23)17(24)10-14/h3-6,9-11,23-24H,7-8H2,1-2H3,(H,22,25)/b15-9+	PDB MMDB KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	1.70E+3	n/a	n/a	n/a	n/a	n/a	n/a
Hebrew University of Jerusalem					Assay Description The activity of EGFR, preactivated with EGF, is measured by its ability to transfer terminal phosphate from [gamma-32P]ATP to poly(GAT) substrate.				J Med Chem 34: 1896-907 (1991) Article DOI: 10.1021/jm00110a022 BindingDB Entry DOI: 10.7270/Q2KW5D7V
					More data for this Ligand-Target Pair