BDBM433311 3-((3S,4S)-4-amino-3- methyl-2-oxa-8- azaspiro[4.5]decan-8-yl)- 6-((2,3- difluorophenyl)thio) pyrazin-2(1H)-one::US10561655, Compound 82
SMILES: C[C@@H]1OCC2(CCN(CC2)c2ncc(Sc3cccc(F)c3F)[nH]c2=O)[C@@H]1N
InChI Key:
Data: 1 IC50
Target/Host (Institution) | Ligand | Target/Host Links | Ligand Links | Trg + Lig Links | Ki nM | ΔG° kcal/mole | IC50 nM | Kd nM | EC50/IC50 nM | koff s-1 | kon M-1s-1 | pH | Temp °C |
---|---|---|---|---|---|---|---|---|---|---|---|---|---|
Tyrosine-protein phosphatase non-receptor type 11 (Homo sapiens (Human)) | BDBM433311 (3-((3S,4S)-4-amino-3- methyl-2-oxa-8- azaspiro[4.5...) | PDB MMDB NCI pathway Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet | PC cid PC sid UniChem | US Patent | n/a | n/a | <50 | n/a | n/a | n/a | n/a | n/a | n/a |
SYNBLia Therapeutics, Inc. US Patent | Assay Description IC50 values were determined at room temperature in 384-well black polystyrene plate, using a final reaction volume of 15 μl and the following as... | US Patent US10561655 (2020) BindingDB Entry DOI: 10.7270/Q23F4S2Z | |||||||||||
More data for this Ligand-Target Pair |