BDBM433316 (R)-3-(3-amino-3H- spiro[benzofuran-2,4'- piperidin]-1'-yl)-6-((2,3- dichlorophenyl)thio) pyrazin-2(1H)-one::US10561655, Compound 87

SMILES: N[C@@H]1c2ccccc2OC11CCN(CC1)c1ncc(Sc2cccc(Cl)c2Cl)[nH]c1=O

InChI Key:

Data: 1 IC50

Find this compound or compounds like it in BindingDB or PDB:

Substructure Similarity at least:  must be >=0.5 Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 1 hit for monomerid = 433316   

Target/Host (Institution)	Ligand	Target/Host Links	Ligand Links	Trg + Lig Links	Ki nM	ΔG° kcal/mole	IC50 nM	Kd nM	EC50/IC50 nM	koff s-1	kon M-1s-1	pH	Temp °C
Tyrosine-protein phosphatase non-receptor type 11 (Homo sapiens (Human))	BDBM433316 ((R)-3-(3-amino-3H- spiro[benzofuran-2,4'- piperidi...) Show SMILES N[C@@H]1c2ccccc2OC11CCN(CC1)c1ncc(Sc2cccc(Cl)c2Cl)[nH]c1=O |r| Show InChI	PDB MMDB NCI pathway Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	<50	n/a	n/a	n/a	n/a	n/a	n/a
SYNBLia Therapeutics, Inc. US Patent					Assay Description IC50 values were determined at room temperature in 384-well black polystyrene plate, using a final reaction volume of 15 μl and the following as...				US Patent US10561655 (2020) BindingDB Entry DOI: 10.7270/Q23F4S2Z
					More data for this Ligand-Target Pair