null

SMILES: Fc1ccc(cc1Cl)C(=O)N1CCC(F)(CNCCOc2cc(ccn2)C(F)(F)F)CC1

InChI Key: InChIKey=JKMPOCIHFLMQKZ-UHFFFAOYSA-N

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 3 hits for monomerid = 433506   

Target/Host (Institution)	Ligand	Target/Host Links	Ligand Links	Trg + Lig Links	Ki nM	ΔG° kcal/mole	IC50 nM	Kd nM	EC50/IC50 nM	koff s-1	kon M-1s-1	pH	Temp °C
5-hydroxytryptamine receptor 1A (Homo sapiens (Human))	BDBM433506 (US10562853, Compound 24) Show SMILES Fc1ccc(cc1Cl)C(=O)N1CCC(F)(CNCCOc2cc(ccn2)C(F)(F)F)CC1 Show InChI InChI=1S/C21H21ClF5N3O2/c22-16-11-14(1-2-17(16)23)19(31)30-8-4-20(24,5-9-30)13-28-7-10-32-18-12-15(3-6-29-18)21(25,26)27/h1-3,6,11-12,28H,4-5,7-10,13H2	PDB UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	0.550	n/a	n/a	n/a	n/a	n/a	n/a	n/a	n/a
NEUROLIXIS; UNIVERSITE JAGELLONE US Patent					Assay Description 5-HT1A: Radioligand binding was performed using membranes from CHO-K1 cells stably transfected with the human 5-HT1A receptor. All assays were carrie...				US Patent US10562853 (2020) BindingDB Entry DOI: 10.7270/Q29Z979D
					More data for this Ligand-Target Pair
D(2) dopamine receptor (Homo sapiens (Human))	BDBM433506 (US10562853, Compound 24) Show SMILES Fc1ccc(cc1Cl)C(=O)N1CCC(F)(CNCCOc2cc(ccn2)C(F)(F)F)CC1 Show InChI InChI=1S/C21H21ClF5N3O2/c22-16-11-14(1-2-17(16)23)19(31)30-8-4-20(24,5-9-30)13-28-7-10-32-18-12-15(3-6-29-18)21(25,26)27/h1-3,6,11-12,28H,4-5,7-10,13H2	PDB Reactome pathway KEGG UniProtKB/SwissProt DrugBank antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	>1.00E+3	n/a	n/a	n/a	n/a	n/a	n/a	n/a	n/a
NEUROLIXIS; UNIVERSITE JAGELLONE US Patent					Assay Description D2 Dopamine Receptor:Radioligand binding was performed using membranes from CHO-K1 cells stably transfected with the human D2 receptor. All assays we...				US Patent US10562853 (2020) BindingDB Entry DOI: 10.7270/Q29Z979D
					More data for this Ligand-Target Pair
Alpha-1A adrenergic receptor (Homo sapiens (Human))	BDBM433506 (US10562853, Compound 24) Show SMILES Fc1ccc(cc1Cl)C(=O)N1CCC(F)(CNCCOc2cc(ccn2)C(F)(F)F)CC1 Show InChI InChI=1S/C21H21ClF5N3O2/c22-16-11-14(1-2-17(16)23)19(31)30-8-4-20(24,5-9-30)13-28-7-10-32-18-12-15(3-6-29-18)21(25,26)27/h1-3,6,11-12,28H,4-5,7-10,13H2	Reactome pathway KEGG UniProtKB/SwissProt DrugBank antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	>1.00E+3	n/a	n/a	n/a	n/a	n/a	n/a	n/a	n/a
NEUROLIXIS; UNIVERSITE JAGELLONE US Patent					Assay Description Alpha1-adrenergic Receptor: Radioligand binding was performed using tissue (rat cortex). All assays were carried out in duplicates. 50 μL workin...				US Patent US10562853 (2020) BindingDB Entry DOI: 10.7270/Q29Z979D
					More data for this Ligand-Target Pair