null

SMILES: C[C@H](NCc1ccc2n(c(NC(=O)c3ccno3)nc2c1)-c1cccc(NC(=O)C=C)c1)C(C)(C)C

InChI Key: InChIKey=ZAJMRDADJLUKEX-KRWDZBQOSA-N

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 3 hits for monomerid = 434528   

Target/Host (Institution)	Ligand	Target/Host Links	Ligand Links	Trg + Lig Links	Ki nM	ΔG° kcal/mole	IC50 nM	Kd nM	EC50/IC50 nM	koff s-1	kon M-1s-1	pH	Temp °C
Tyrosine-protein kinase ITK/TSK (Homo sapiens (Human))	BDBM434528 (US10562893, Compound 38) Show SMILES C[C@H](NCc1ccc2n(c(NC(=O)c3ccno3)nc2c1)-c1cccc(NC(=O)C=C)c1)C(C)(C)C |r| Show InChI InChI=1S/C27H30N6O3/c1-6-24(34)30-19-8-7-9-20(15-19)33-22-11-10-18(16-28-17(2)27(3,4)5)14-21(22)31-26(33)32-25(35)23-12-13-29-36-23/h6-15,17,28H,1,16H2,2-5H3,(H,30,34)(H,31,32,35)/t17-/m0/s1	PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	n/a	n/a	<10	n/a	n/a	n/a	n/a
GB005, INC. US Patent					Assay Description ITK: The in vitro kinase assays were performed at Nanosyn utilizing micro-fluidic detection technology. The test compounds were serially pre-diluted ...				US Patent US10562893 (2020) BindingDB Entry DOI: 10.7270/Q2571FC8
					More data for this Ligand-Target Pair
Tyrosine-protein kinase Tec (Homo sapiens (Human))	BDBM434528 (US10562893, Compound 38) Show SMILES C[C@H](NCc1ccc2n(c(NC(=O)c3ccno3)nc2c1)-c1cccc(NC(=O)C=C)c1)C(C)(C)C |r| Show InChI InChI=1S/C27H30N6O3/c1-6-24(34)30-19-8-7-9-20(15-19)33-22-11-10-18(16-28-17(2)27(3,4)5)14-21(22)31-26(33)32-25(35)23-12-13-29-36-23/h6-15,17,28H,1,16H2,2-5H3,(H,30,34)(H,31,32,35)/t17-/m0/s1	PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	n/a	n/a	55	n/a	n/a	n/a	n/a
GB005, INC. US Patent					Assay Description Tec: The in vitro kinase assays were performed at Nanosyn utilizing micro-fluidic detection technology. The test compounds were serially pre-diluted ...				US Patent US10562893 (2020) BindingDB Entry DOI: 10.7270/Q2571FC8
					More data for this Ligand-Target Pair
Tyrosine-protein kinase TXK (Homo sapiens (Human))	BDBM434528 (US10562893, Compound 38) Show SMILES C[C@H](NCc1ccc2n(c(NC(=O)c3ccno3)nc2c1)-c1cccc(NC(=O)C=C)c1)C(C)(C)C |r| Show InChI InChI=1S/C27H30N6O3/c1-6-24(34)30-19-8-7-9-20(15-19)33-22-11-10-18(16-28-17(2)27(3,4)5)14-21(22)31-26(33)32-25(35)23-12-13-29-36-23/h6-15,17,28H,1,16H2,2-5H3,(H,30,34)(H,31,32,35)/t17-/m0/s1	PDB UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	n/a	n/a	<10	n/a	n/a	n/a	n/a
GB005, INC. US Patent					Assay Description RLK/TXK: The in vitro kinase assays were performed at Nanosyn utilizing micro-fluidic detection technology. The test compounds were serially pre-dilu...				US Patent US10562893 (2020) BindingDB Entry DOI: 10.7270/Q2571FC8
					More data for this Ligand-Target Pair