Found 6 hits for monomerid = 435144 Target/Host (Institution) | Ligand | Target/Host Links | Ligand Links | Trg + Lig Links | Ki nM | ΔG° kcal/mole | IC50 nM | Kd nM | EC50/IC50 nM | koff s-1 | kon M-1s-1 | pH | Temp °C |
Glutamate receptor ionotropic, NMDA 2B
(Homo sapiens (Human)) | BDBM435144
(US10584127, Compound E1-2.2 | US11136328, Compound...)Show SMILES Cc1ccc(COC(=O)N2CC[C@H](CNc3cncc4nncn34)C(F)(F)C2)cc1 |r| Show InChI InChI=1S/C20H22F2N6O2/c1-14-2-4-15(5-3-14)11-30-19(29)27-7-6-16(20(21,22)12-27)8-24-17-9-23-10-18-26-25-13-28(17)18/h2-5,9-10,13,16,24H,6-8,11-12H2,1H3/t16-/m1/s1 | PDB MMDB
NCI pathway Reactome pathway KEGG
UniProtKB/SwissProt
B.MOAD DrugBank antibodypedia GoogleScholar AffyNet
| PC cid PC sid UniChem
| US Patent
| n/a | n/a | 10.4 | n/a | n/a | n/a | n/a | n/a | n/a |
Rugen Holdings (Cayman) Limited
US Patent
| Assay Description HEK293 cell lines stably expressing cloned human NR1/NR2B and NR1/NR2A, respectively, were established according to standard previously described met... |
US Patent US10584127 (2020)
BindingDB Entry DOI: 10.7270/Q2Q242NP |
More data for this Ligand-Target Pair | |
Glutamate receptor ionotropic, NMDA 2A
(Homo sapiens (Human)) | BDBM435144
(US10584127, Compound E1-2.2 | US11136328, Compound...)Show SMILES Cc1ccc(COC(=O)N2CC[C@H](CNc3cncc4nncn34)C(F)(F)C2)cc1 |r| Show InChI InChI=1S/C20H22F2N6O2/c1-14-2-4-15(5-3-14)11-30-19(29)27-7-6-16(20(21,22)12-27)8-24-17-9-23-10-18-26-25-13-28(17)18/h2-5,9-10,13,16,24H,6-8,11-12H2,1H3/t16-/m1/s1 | PDB
UniProtKB/SwissProt UniProtKB/TrEMBL
antibodypedia GoogleScholar AffyNet
| PC cid PC sid UniChem
| US Patent
| n/a | n/a | >1.00E+7 | n/a | n/a | n/a | n/a | n/a | n/a |
Rugen Holdings (Cayman) Limited
US Patent
| Assay Description HEK293 cell lines stably expressing cloned human NR1/NR2B and NR1/NR2A, respectively, were established according to standard previously described met... |
US Patent US10584127 (2020)
BindingDB Entry DOI: 10.7270/Q2Q242NP |
More data for this Ligand-Target Pair | |
Glutamate receptor ionotropic, NMDA 2B
(Homo sapiens (Human)) | BDBM435144
(US10584127, Compound E1-2.2 | US11136328, Compound...)Show SMILES Cc1ccc(COC(=O)N2CC[C@H](CNc3cncc4nncn34)C(F)(F)C2)cc1 |r| Show InChI InChI=1S/C20H22F2N6O2/c1-14-2-4-15(5-3-14)11-30-19(29)27-7-6-16(20(21,22)12-27)8-24-17-9-23-10-18-26-25-13-28(17)18/h2-5,9-10,13,16,24H,6-8,11-12H2,1H3/t16-/m1/s1 | PDB MMDB
NCI pathway Reactome pathway KEGG
UniProtKB/SwissProt
B.MOAD DrugBank antibodypedia GoogleScholar AffyNet
| PC cid PC sid UniChem
| | n/a | n/a | 10.4 | n/a | n/a | n/a | n/a | n/a | n/a |
TBA
| |
Citation and Details
|
More data for this Ligand-Target Pair | |
Glutamate receptor ionotropic, NMDA 2A
(Homo sapiens (Human)) | BDBM435144
(US10584127, Compound E1-2.2 | US11136328, Compound...)Show SMILES Cc1ccc(COC(=O)N2CC[C@H](CNc3cncc4nncn34)C(F)(F)C2)cc1 |r| Show InChI InChI=1S/C20H22F2N6O2/c1-14-2-4-15(5-3-14)11-30-19(29)27-7-6-16(20(21,22)12-27)8-24-17-9-23-10-18-26-25-13-28(17)18/h2-5,9-10,13,16,24H,6-8,11-12H2,1H3/t16-/m1/s1 | PDB
UniProtKB/SwissProt UniProtKB/TrEMBL
antibodypedia GoogleScholar AffyNet
| PC cid PC sid UniChem
| | n/a | n/a | >1.00E+4 | n/a | n/a | n/a | n/a | n/a | n/a |
TBA
| |
Citation and Details
|
More data for this Ligand-Target Pair | |
Glutamate receptor ionotropic, NMDA 2B
(Homo sapiens (Human)) | BDBM435144
(US10584127, Compound E1-2.2 | US11136328, Compound...)Show SMILES Cc1ccc(COC(=O)N2CC[C@H](CNc3cncc4nncn34)C(F)(F)C2)cc1 |r| Show InChI InChI=1S/C20H22F2N6O2/c1-14-2-4-15(5-3-14)11-30-19(29)27-7-6-16(20(21,22)12-27)8-24-17-9-23-10-18-26-25-13-28(17)18/h2-5,9-10,13,16,24H,6-8,11-12H2,1H3/t16-/m1/s1 | PDB MMDB
NCI pathway Reactome pathway KEGG
UniProtKB/SwissProt
B.MOAD DrugBank antibodypedia GoogleScholar AffyNet
| PC cid PC sid UniChem
| | n/a | n/a | 10.4 | n/a | n/a | n/a | n/a | n/a | n/a |
TBA
| |
Citation and Details
|
More data for this Ligand-Target Pair | |
Glutamate receptor ionotropic, NMDA 2B
(Homo sapiens (Human)) | BDBM435144
(US10584127, Compound E1-2.2 | US11136328, Compound...)Show SMILES Cc1ccc(COC(=O)N2CC[C@H](CNc3cncc4nncn34)C(F)(F)C2)cc1 |r| Show InChI InChI=1S/C20H22F2N6O2/c1-14-2-4-15(5-3-14)11-30-19(29)27-7-6-16(20(21,22)12-27)8-24-17-9-23-10-18-26-25-13-28(17)18/h2-5,9-10,13,16,24H,6-8,11-12H2,1H3/t16-/m1/s1 | PDB MMDB
NCI pathway Reactome pathway KEGG
UniProtKB/SwissProt
B.MOAD DrugBank antibodypedia GoogleScholar AffyNet
| PC cid PC sid UniChem
| | n/a | n/a | 10.4 | n/a | n/a | n/a | n/a | n/a | n/a |
TBA
| |
Citation and Details
|
More data for this Ligand-Target Pair | |