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SMILES: COC(=O)c1cccc(c1)-c1ccc(CNC(=O)C2CC2c2ccccc2)c2CN(CCc12)C(=O)C1(CC1)C#N

InChI Key: InChIKey=SKVNWDJBXZWAOL-UHFFFAOYSA-N

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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 1 hit for monomerid = 435368   
Target/Host
(Institution)		LigandTarget/Host
Links		Ligand
Links		Trg + Lig
Links		Ki
nM		ΔG°
kcal/mole		IC50
nM		Kd
nM		EC50/IC50
nM		koff
s-1		kon
M-1s-1		pHTemp
°C
Diacylglycerol O-acyltransferase 2


(Homo sapiens (Human))		BDBM435368
PNG
(US10568876, Example 128 | methyl 3-(2-(1- cyanocyc...)
Show SMILES COC(=O)c1cccc(c1)-c1ccc(CNC(=O)C2CC2c2ccccc2)c2CN(CCc12)C(=O)C1(CC1)C#N
Show InChI InChI=1S/C33H31N3O4/c1-40-31(38)23-9-5-8-22(16-23)25-11-10-24(18-35-30(37)28-17-27(28)21-6-3-2-4-7-21)29-19-36(15-12-26(25)29)32(39)33(20-34)13-14-33/h2-11,16,27-28H,12-15,17-19H2,1H3,(H,35,37)
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UniProtKB/SwissProt

antibodypedia
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PC cid
PC sid
UniChem
US Patent
n/an/a 1.59E+3n/an/an/an/an/an/a



Merck Sharp & Dohme Corp.

US Patent


Assay Description
DGAT2 activity was determined by measuring the amount of enzymatic product triolein (1,2,3-Tri(cis-9-octadecenoyl)glycerol) using the membrane prep m...

US Patent US10568876 (2020)


BindingDB Entry DOI: 10.7270/Q22B91FB
More data for this
Ligand-Target Pair