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SMILES: COc1cc(ccc1O)C(\C)=C(/C#N)C(O)=O

InChI Key: InChIKey=NFHQLTFHKJHSIE-VQHVLOKHSA-N

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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 1 hit for monomerid = 4354   
Target/Host
(Institution)		LigandTarget/Host
Links		Ligand
Links		Trg + Lig
Links		Ki
nM		ΔG°
kcal/mole		IC50
nM		Kd
nM		EC50/IC50
nM		koff
s-1		kon
M-1s-1		pHTemp
°C
Epidermal growth factor receptor


(Homo sapiens (Human))		BDBM4354
PNG
((2E)-2-cyano-3-(4-hydroxy-3-methoxyphenyl)but-2-en...)
Show SMILES COc1cc(ccc1O)C(\C)=C(/C#N)C(O)=O
Show InChI InChI=1S/C12H11NO4/c1-7(9(6-13)12(15)16)8-3-4-10(14)11(5-8)17-2/h3-5,14H,1-2H3,(H,15,16)/b9-7+
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Similars
Article
PubMed
 3.41E+5n/a 1.10E+6n/an/an/an/an/an/a



Hebrew University of Jerusalem



Assay Description
The activity of EGFR, preactivated with EGF, is measured by its ability to transfer terminal phosphate from [gamma-32P]ATP to poly(GAT) substrate.

J Med Chem 32: 2344-52 (1989)


Article DOI: 10.1021/jm00130a020
BindingDB Entry DOI: 10.7270/Q2G44NHF
More data for this
Ligand-Target Pair