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SMILES: OC[C@]1(O)CN(C[C@@H]1Cc1ccc(C#N)c(F)c1)S(=O)(=O)c1ccc(cc1C#N)C(F)(F)F

InChI Key: InChIKey=RDXAJICEALUQOJ-FXAWDEMLSA-N

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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 1 hit for monomerid = 436104   
Target/Host
(Institution)		LigandTarget/Host
Links		Ligand
Links		Trg + Lig
Links		Ki
nM		ΔG°
kcal/mole		IC50
nM		Kd
nM		EC50/IC50
nM		koff
s-1		kon
M-1s-1		pHTemp
°C
Transient receptor potential cation channel subfamily V member 4


(Homo sapiens (Human))		BDBM436104
PNG
(4-(((3S,4R)-1- ((2-cyano-4- (trifluoromethyl) phen...)
Show SMILES OC[C@]1(O)CN(C[C@@H]1Cc1ccc(C#N)c(F)c1)S(=O)(=O)c1ccc(cc1C#N)C(F)(F)F |r|
Show InChI InChI=1S/C21H17F4N3O4S/c22-18-6-13(1-2-14(18)8-26)5-17-10-28(11-20(17,30)12-29)33(31,32)19-4-3-16(21(23,24)25)7-15(19)9-27/h1-4,6-7,17,29-30H,5,10-12H2/t17-,20+/m0/s1
PDB

UniProtKB/SwissProt

antibodypedia
GoogleScholar
AffyNet 
PC cid
PC sid
UniChem
US Patent
n/an/a 5n/an/an/an/an/an/a



GlaxoSmithKline Intellectual Property Development Limited

US Patent


Assay Description
TRPV4 channel activation results in an influx of divalent and monovalent cations including calcium. The resulting changes in intracellular calcium we...

US Patent US10590077 (2020)


BindingDB Entry DOI: 10.7270/Q2XK8JJP
More data for this
Ligand-Target Pair