BDBM436197 US10590109, Compound 15::US10590109, Compound 20

SMILES: COCCNc1cc(NC(=O)N(C)c2ccc(CN3CCN(C)CC3=O)c(C=O)n2)ncc1C#N

InChI Key: InChIKey=WMIQOTMTEKRJFD-UHFFFAOYSA-N

Data: 6 IC50

Find this compound or compounds like it in BindingDB or PDB:

Substructure Similarity at least:  must be >=0.5 Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 9 hits for monomerid = 436197   

Target/Host (Institution)	Ligand	Target/Host Links	Ligand Links	Trg + Lig Links	Ki nM	ΔG° kcal/mole	IC50 nM	Kd nM	EC50/IC50 nM	koff s-1	kon M-1s-1	pH	Temp °C
Fibroblast growth factor receptor 4 (FGFR4)(aa 460-802) (Homo sapiens (Human))	BDBM436197 (US10590109, Compound 15 | US10590109, Compound 20) Show SMILES COCCNc1cc(NC(=O)N(C)c2ccc(CN3CCN(C)CC3=O)c(C=O)n2)ncc1C#N Show InChI InChI=1S/C23H28N8O4/c1-29-7-8-31(22(33)14-29)13-16-4-5-21(27-19(16)15-32)30(2)23(34)28-20-10-18(25-6-9-35-3)17(11-24)12-26-20/h4-5,10,12,15H,6-9,13-14H2,1-3H3,(H2,25,26,28,34)	PDB MMDB B.MOAD GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	55	n/a	n/a	n/a	n/a	n/a	n/a
Nanjing InnoCare Pharma Tech Co., Ltd. US Patent					Assay Description FGFR4:The in vitro activity of FGFR4 was determined by assaying the phosphorylation level of the substrate in the kinase reaction, by means of an HTR...				US Patent US10590109 (2020)
					More data for this Ligand-Target Pair
Fibroblast growth factor receptor 1 (FGFR1)(aa 308-731) (Homo sapiens (Human))	BDBM436197 (US10590109, Compound 15 | US10590109, Compound 20) Show SMILES COCCNc1cc(NC(=O)N(C)c2ccc(CN3CCN(C)CC3=O)c(C=O)n2)ncc1C#N Show InChI InChI=1S/C23H28N8O4/c1-29-7-8-31(22(33)14-29)13-16-4-5-21(27-19(16)15-32)30(2)23(34)28-20-10-18(25-6-9-35-3)17(11-24)12-26-20/h4-5,10,12,15H,6-9,13-14H2,1-3H3,(H2,25,26,28,34)	PDB GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	>1.00E+3	n/a	n/a	n/a	n/a	n/a	n/a
Nanjing InnoCare Pharma Tech Co., Ltd. US Patent					Assay Description FGFR1: The in vitro activity of FGFR1 was determined by assaying the phosphorylation level of the substrate in the kinase reaction, by means of an HT...				US Patent US10590109 (2020)
					More data for this Ligand-Target Pair
Fibroblast growth factor receptor 4 (FGFR4)(aa 460-802) (Homo sapiens (Human))	BDBM436197 (US10590109, Compound 15 | US10590109, Compound 20) Show SMILES COCCNc1cc(NC(=O)N(C)c2ccc(CN3CCN(C)CC3=O)c(C=O)n2)ncc1C#N Show InChI InChI=1S/C23H28N8O4/c1-29-7-8-31(22(33)14-29)13-16-4-5-21(27-19(16)15-32)30(2)23(34)28-20-10-18(25-6-9-35-3)17(11-24)12-26-20/h4-5,10,12,15H,6-9,13-14H2,1-3H3,(H2,25,26,28,34)	PDB MMDB B.MOAD GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	<10	n/a	n/a	n/a	n/a	n/a	n/a
Nanjing InnoCare Pharma Tech Co., Ltd. US Patent					Assay Description FGFR4:The in vitro activity of FGFR4 was determined by assaying the phosphorylation level of the substrate in the kinase reaction, by means of an HTR...				US Patent US10590109 (2020)
					More data for this Ligand-Target Pair
Fibroblast growth factor receptor 1 (FGFR1)(aa 308-731) (Homo sapiens (Human))	BDBM436197 (US10590109, Compound 15 | US10590109, Compound 20) Show SMILES COCCNc1cc(NC(=O)N(C)c2ccc(CN3CCN(C)CC3=O)c(C=O)n2)ncc1C#N Show InChI InChI=1S/C23H28N8O4/c1-29-7-8-31(22(33)14-29)13-16-4-5-21(27-19(16)15-32)30(2)23(34)28-20-10-18(25-6-9-35-3)17(11-24)12-26-20/h4-5,10,12,15H,6-9,13-14H2,1-3H3,(H2,25,26,28,34)	PDB GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	>1.00E+3	n/a	n/a	n/a	n/a	n/a	n/a
Nanjing InnoCare Pharma Tech Co., Ltd. US Patent					Assay Description FGFR1: The in vitro activity of FGFR1 was determined by assaying the phosphorylation level of the substrate in the kinase reaction, by means of an HT...				US Patent US10590109 (2020)
					More data for this Ligand-Target Pair
Fibroblast growth factor receptor (Mus musculus)	BDBM436197 (US10590109, Compound 15 | US10590109, Compound 20) Show SMILES COCCNc1cc(NC(=O)N(C)c2ccc(CN3CCN(C)CC3=O)c(C=O)n2)ncc1C#N Show InChI InChI=1S/C23H28N8O4/c1-29-7-8-31(22(33)14-29)13-16-4-5-21(27-19(16)15-32)30(2)23(34)28-20-10-18(25-6-9-35-3)17(11-24)12-26-20/h4-5,10,12,15H,6-9,13-14H2,1-3H3,(H2,25,26,28,34)	PDB Reactome pathway KEGG UniProtKB/SwissProt GoogleScholar AffyNet	PC cid PC sid UniChem		n/a	n/a	3.70	n/a	n/a	n/a	n/a	n/a	n/a
TBA									Citation and Details
					More data for this Ligand-Target Pair
Fibroblast growth factor receptor 3 (FGFR3)(aa 399-806) (Homo sapiens (Human))	BDBM436197 (US10590109, Compound 15 | US10590109, Compound 20) Show SMILES COCCNc1cc(NC(=O)N(C)c2ccc(CN3CCN(C)CC3=O)c(C=O)n2)ncc1C#N Show InChI InChI=1S/C23H28N8O4/c1-29-7-8-31(22(33)14-29)13-16-4-5-21(27-19(16)15-32)30(2)23(34)28-20-10-18(25-6-9-35-3)17(11-24)12-26-20/h4-5,10,12,15H,6-9,13-14H2,1-3H3,(H2,25,26,28,34)	PDB GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	>1.00E+3	n/a	n/a	n/a	n/a	n/a	n/a
Nanjing InnoCare Pharma Tech Co., Ltd. US Patent					Assay Description FGFR3: The in vitro activity of FGFR3 was determined by assaying the phosphorylation level of the substrate in the kinase reaction, by means of an HT...				US Patent US10590109 (2020)
					More data for this Ligand-Target Pair
1,3-beta-glucan synthase component GLS2 (Saccharomyces cerevisiae)	BDBM436197 (US10590109, Compound 15 | US10590109, Compound 20) Show SMILES COCCNc1cc(NC(=O)N(C)c2ccc(CN3CCN(C)CC3=O)c(C=O)n2)ncc1C#N Show InChI InChI=1S/C23H28N8O4/c1-29-7-8-31(22(33)14-29)13-16-4-5-21(27-19(16)15-32)30(2)23(34)28-20-10-18(25-6-9-35-3)17(11-24)12-26-20/h4-5,10,12,15H,6-9,13-14H2,1-3H3,(H2,25,26,28,34)	KEGG UniProtKB/SwissProt GoogleScholar AffyNet	PC cid PC sid UniChem		n/a	n/a	>3.00E+4	n/a	n/a	n/a	n/a	n/a	n/a
TBA									Citation and Details
					More data for this Ligand-Target Pair
Fibroblast growth factor receptor (Mus musculus)	BDBM436197 (US10590109, Compound 15 | US10590109, Compound 20) Show SMILES COCCNc1cc(NC(=O)N(C)c2ccc(CN3CCN(C)CC3=O)c(C=O)n2)ncc1C#N Show InChI InChI=1S/C23H28N8O4/c1-29-7-8-31(22(33)14-29)13-16-4-5-21(27-19(16)15-32)30(2)23(34)28-20-10-18(25-6-9-35-3)17(11-24)12-26-20/h4-5,10,12,15H,6-9,13-14H2,1-3H3,(H2,25,26,28,34)	PDB Reactome pathway KEGG UniProtKB/SwissProt GoogleScholar AffyNet	PC cid PC sid UniChem		n/a	n/a	66	n/a	n/a	n/a	n/a	n/a	n/a
TBA									Citation and Details
					More data for this Ligand-Target Pair
Fibroblast growth factor receptor 2 (FGFR2)(aa 400-821) (Homo sapiens (Human))	BDBM436197 (US10590109, Compound 15 | US10590109, Compound 20) Show SMILES COCCNc1cc(NC(=O)N(C)c2ccc(CN3CCN(C)CC3=O)c(C=O)n2)ncc1C#N Show InChI InChI=1S/C23H28N8O4/c1-29-7-8-31(22(33)14-29)13-16-4-5-21(27-19(16)15-32)30(2)23(34)28-20-10-18(25-6-9-35-3)17(11-24)12-26-20/h4-5,10,12,15H,6-9,13-14H2,1-3H3,(H2,25,26,28,34)	PDB GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	>1.00E+3	n/a	n/a	n/a	n/a	n/a	n/a
Nanjing InnoCare Pharma Tech Co., Ltd. US Patent					Assay Description FGFR2: The in vitro activity of FGFR2 was determined by assaying the phosphorylation level of the substrate in the kinase reaction, by means of an HT...				US Patent US10590109 (2020)
					More data for this Ligand-Target Pair