null
SMILES: CC(C)n1cnnc1-c1cccc(n1)N1Cc2ccc(cc2C1=O)-c1cc(cc(c1)C(O)=O)C#N
InChI Key: InChIKey=SAVQZCMCQQJSAP-UHFFFAOYSA-N
Target/Host (Institution) | Ligand | Target/Host Links | Ligand Links | Trg + Lig Links | Ki nM | ΔG° kcal/mole | IC50 nM | Kd nM | EC50/IC50 nM | koff s-1 | kon M-1s-1 | pH | Temp °C |
---|---|---|---|---|---|---|---|---|---|---|---|---|---|
Mitogen-activated protein kinase kinase kinase 5 (Homo sapiens (Human)) | BDBM443135 (US10654833, Compound 13) | PDB KEGG UniProtKB/SwissProt B.MOAD antibodypedia GoogleScholar AffyNet | PC cid PC sid UniChem | US Patent | n/a | n/a | 1.60 | n/a | n/a | n/a | n/a | n/a | n/a |
Hepatikos Therapeutics, LLC US Patent | Assay Description Inhibition of ASK1 kinase activity was determined radiometrically using 33P substrate incorporation (Reaction Biology Corp., Malvern, Pa.). Briefly, ... | US Patent US10654833 (2020) | |||||||||||
More data for this Ligand-Target Pair |