BDBM444440 US10662159, Example 25

SMILES: FC(F)(F)C(OC(=O)N1Cc2ccc(cc2C1)-c1ccccc1)C(F)(F)F

InChI Key: InChIKey=CEIXXPVHWOLVPN-UHFFFAOYSA-N

Data: 3 IC50

Find this compound or compounds like it in BindingDB or PDB:

Substructure Similarity at least:  must be >=0.5 Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 3 hits for monomerid = 444440   

Target/Host (Institution)	Ligand	Target/Host Links	Ligand Links	Trg + Lig Links	Ki nM	ΔG° kcal/mole	IC50 nM	Kd nM	EC50/IC50 nM	koff s-1	kon M-1s-1	pH	Temp °C
Monoacylglycerol lipase ABHD6 (Homo sapiens (Human))	BDBM444440 (US10662159, Example 25) Show SMILES FC(F)(F)C(OC(=O)N1Cc2ccc(cc2C1)-c1ccccc1)C(F)(F)F Show InChI InChI=1S/C18H13F6NO2/c19-17(20,21)15(18(22,23)24)27-16(26)25-9-13-7-6-12(8-14(13)10-25)11-4-2-1-3-5-11/h1-8,15H,9-10H2	PDB UniProtKB/SwissProt UniProtKB/TrEMBL GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	55	n/a	n/a	n/a	n/a	n/a	n/a
MAKSCIENTIFIC, LLC US Patent					Assay Description ABHD6: Certain compounds were tested for their ABHD6 and dual ABHD6/MGL inhibitory activity, which is expressed as % of inhibition or IC50 values. Th...				US Patent US10662159 (2020)
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Fatty-acid amide hydrolase 1 (Homo sapiens (Human))	BDBM444440 (US10662159, Example 25) Show SMILES FC(F)(F)C(OC(=O)N1Cc2ccc(cc2C1)-c1ccccc1)C(F)(F)F Show InChI InChI=1S/C18H13F6NO2/c19-17(20,21)15(18(22,23)24)27-16(26)25-9-13-7-6-12(8-14(13)10-25)11-4-2-1-3-5-11/h1-8,15H,9-10H2	PDB UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	>1.00E+3	n/a	n/a	n/a	n/a	n/a	n/a
MAKSCIENTIFIC, LLC US Patent					Assay Description Rat/homo FAAH:Procedure was followed as described for hMGL, except that arachidonoyl-methyl coumarin (was used as fluorigenic substrate. Compounds we...				US Patent US10662159 (2020)
					More data for this Ligand-Target Pair
Monoglyceride lipase (Homo sapiens (Human))	BDBM444440 (US10662159, Example 25) Show SMILES FC(F)(F)C(OC(=O)N1Cc2ccc(cc2C1)-c1ccccc1)C(F)(F)F Show InChI InChI=1S/C18H13F6NO2/c19-17(20,21)15(18(22,23)24)27-16(26)25-9-13-7-6-12(8-14(13)10-25)11-4-2-1-3-5-11/h1-8,15H,9-10H2	PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	>1.00E+3	n/a	n/a	n/a	n/a	n/a	n/a
MAKSCIENTIFIC, LLC US Patent					Assay Description MGL: Compound inhibition of hMGL activity was assessed by a fluorometric assay recently developed in our laboratory (Makriyannis et al WO Patent Appl...				US Patent US10662159 (2020)
					More data for this Ligand-Target Pair