BindingDB logo
myBDB logout

BDBM444447 US10662159, Example 32

SMILES: FC(F)(F)C(OC(=O)N1Cc2ccc(cc2C1)N1CCOCC1)C(F)(F)F

InChI Key: InChIKey=MHJDDOFYLDYGBR-UHFFFAOYSA-N

Data: 3 IC50

Find this compound or compounds like it in BindingDB or PDB:
   Substructure
Similarity at least:  must be >=0.5
Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 3 hits for monomerid = 444447   
Target/Host
(Institution)
LigandTarget/Host
Links
Ligand
Links
Trg + Lig
Links
Ki
nM
ΔG°
kcal/mole
IC50
nM
Kd
nM
EC50/IC50
nM
koff
s-1
kon
M-1s-1
pHTemp
°C
Monoacylglycerol lipase ABHD6


(Homo sapiens (Human))
BDBM444447
PNG
(US10662159, Example 32)
Show SMILES FC(F)(F)C(OC(=O)N1Cc2ccc(cc2C1)N1CCOCC1)C(F)(F)F
Show InChI InChI=1S/C16H16F6N2O3/c17-15(18,19)13(16(20,21)22)27-14(25)24-8-10-1-2-12(7-11(10)9-24)23-3-5-26-6-4-23/h1-2,7,13H,3-6,8-9H2
PDB

UniProtKB/SwissProt
UniProtKB/TrEMBL

GoogleScholar
AffyNet 
PC cid
PC sid
UniChem
US Patent
n/an/a 55n/an/an/an/an/an/a



MAKSCIENTIFIC, LLC

US Patent


Assay Description
ABHD6: Certain compounds were tested for their ABHD6 and dual ABHD6/MGL inhibitory activity, which is expressed as % of inhibition or IC50 values. Th...


US Patent US10662159 (2020)

More data for this
Ligand-Target Pair
Fatty-acid amide hydrolase 1


(Homo sapiens (Human))
BDBM444447
PNG
(US10662159, Example 32)
Show SMILES FC(F)(F)C(OC(=O)N1Cc2ccc(cc2C1)N1CCOCC1)C(F)(F)F
Show InChI InChI=1S/C16H16F6N2O3/c17-15(18,19)13(16(20,21)22)27-14(25)24-8-10-1-2-12(7-11(10)9-24)23-3-5-26-6-4-23/h1-2,7,13H,3-6,8-9H2
PDB

UniProtKB/SwissProt

antibodypedia
GoogleScholar
AffyNet 
PC cid
PC sid
UniChem
US Patent
n/an/a>1.00E+3n/an/an/an/an/an/a



MAKSCIENTIFIC, LLC

US Patent


Assay Description
Rat/homo FAAH:Procedure was followed as described for hMGL, except that arachidonoyl-methyl coumarin (was used as fluorigenic substrate. Compounds we...


US Patent US10662159 (2020)

More data for this
Ligand-Target Pair
Monoglyceride lipase


(Homo sapiens (Human))
BDBM444447
PNG
(US10662159, Example 32)
Show SMILES FC(F)(F)C(OC(=O)N1Cc2ccc(cc2C1)N1CCOCC1)C(F)(F)F
Show InChI InChI=1S/C16H16F6N2O3/c17-15(18,19)13(16(20,21)22)27-14(25)24-8-10-1-2-12(7-11(10)9-24)23-3-5-26-6-4-23/h1-2,7,13H,3-6,8-9H2
PDB
MMDB

Reactome pathway
KEGG

UniProtKB/SwissProt

B.MOAD
antibodypedia
GoogleScholar
AffyNet 
PC cid
PC sid
UniChem
US Patent
n/an/a>1.00E+3n/an/an/an/an/an/a



MAKSCIENTIFIC, LLC

US Patent


Assay Description
MGL: Compound inhibition of hMGL activity was assessed by a fluorometric assay recently developed in our laboratory (Makriyannis et al WO Patent Appl...


US Patent US10662159 (2020)

More data for this
Ligand-Target Pair