null

SMILES: Fc1cc(N[C@@H]2CCN(C2)c2ccccc2)c(Cl)cc1S(=O)(=O)Nc1nccs1

InChI Key: InChIKey=IXJXVJVVOXLEOM-CYBMUJFWSA-N

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 2 hits for monomerid = 444514   

Target/Host (Institution)	Ligand	Target/Host Links	Ligand Links	Trg + Lig Links	Ki nM	ΔG° kcal/mole	IC50 nM	Kd nM	EC50/IC50 nM	koff s-1	kon M-1s-1	pH	Temp °C
Sodium channel protein type 1 subunit alpha (Homo sapiens (Human))	BDBM444514 ((R)-4-(1-benzylpyrrolidin-3-ylamino)-5-chloro- 2-f...) Show SMILES Fc1cc(N[C@@H]2CCN(C2)c2ccccc2)c(Cl)cc1S(=O)(=O)Nc1nccs1 |r| Show InChI InChI=1S/C19H18ClFN4O2S2/c20-15-10-18(29(26,27)24-19-22-7-9-28-19)16(21)11-17(15)23-13-6-8-25(12-13)14-4-2-1-3-5-14/h1-5,7,9-11,13,23H,6,8,12H2,(H,22,24)/t13-/m1/s1	PDB UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	2.87E+3	n/a	n/a	n/a	n/a	n/a	n/a
Xenon Pharmaceuticals Inc. US Patent					Assay Description The following patch voltage clamp electrophysiology studies were performed on representative compounds of the invention using human embryonic kidney ...				US Patent US10662184 (2020) BindingDB Entry DOI: 10.7270/Q2MK6GZP
					More data for this Ligand-Target Pair
Sodium channel protein type 8 subunit alpha (Homo sapiens (Human))	BDBM444514 ((R)-4-(1-benzylpyrrolidin-3-ylamino)-5-chloro- 2-f...) Show SMILES Fc1cc(N[C@@H]2CCN(C2)c2ccccc2)c(Cl)cc1S(=O)(=O)Nc1nccs1 |r| Show InChI InChI=1S/C19H18ClFN4O2S2/c20-15-10-18(29(26,27)24-19-22-7-9-28-19)16(21)11-17(15)23-13-6-8-25(12-13)14-4-2-1-3-5-14/h1-5,7,9-11,13,23H,6,8,12H2,(H,22,24)/t13-/m1/s1	PDB Reactome pathway KEGG UniProtKB/SwissProt DrugBank GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	91	n/a	n/a	n/a	n/a	n/a	n/a
Xenon Pharmaceuticals Inc. US Patent					Assay Description The following patch voltage clamp electrophysiology studies were performed on representative compounds of the invention using human embryonic kidney ...				US Patent US10662184 (2020) BindingDB Entry DOI: 10.7270/Q2MK6GZP
					More data for this Ligand-Target Pair