BDBM445212 US10669235, Example 3

SMILES: COC(=O)c1cc2NC(=O)\C(=C(/Nc3ccc(cc3)C(=O)NCC3CCN(C)CC3)c3ccccc3)c2cc1C

InChI Key: InChIKey=UKGLXBBBCMZJSW-ZIADKAODSA-N

Data: 6 KI

Find this compound or compounds like it in BindingDB or PDB:

Substructure Similarity at least:  must be >=0.5 Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 12 hits for monomerid = 445212   

Target/Host (Institution)	Ligand	Target/Host Links	Ligand Links	Trg + Lig Links	Ki nM	ΔG° kcal/mole	IC50 nM	Kd nM	EC50/IC50 nM	koff s-1	kon M-1s-1	pH	Temp °C
Platelet-derived growth factor receptor beta (Homo sapiens (Human))	BDBM445212 (US10669235, Example 3 | US11208381, Example 3) Show SMILES COC(=O)c1cc2NC(=O)\C(=C(/Nc3ccc(cc3)C(=O)NCC3CCN(C)CC3)c3ccccc3)c2cc1C Show InChI InChI=1S/C32H34N4O4/c1-20-17-26-27(18-25(20)32(39)40-3)35-31(38)28(26)29(22-7-5-4-6-8-22)34-24-11-9-23(10-12-24)30(37)33-19-21-13-15-36(2)16-14-21/h4-12,17-18,21,34H,13-16,19H2,1-3H3,(H,33,37)(H,35,38)/b29-28-	PDB MMDB NCI pathway Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	6.86	n/a	n/a	n/a	n/a	n/a	n/a	n/a	n/a
RESPIVERT LIMITED US Patent					Assay Description The inhibitory activities of compounds of the invention against PDGFRβ (PDGFRβ Kinase Enzyme System: Promega), were evaluated by mixing the...				US Patent US10669235 (2020)
					More data for this Ligand-Target Pair
VHL/PDGFRB (Homo sapiens (Human))	BDBM445212 (US10669235, Example 3 | US11208381, Example 3) Show SMILES COC(=O)c1cc2NC(=O)\C(=C(/Nc3ccc(cc3)C(=O)NCC3CCN(C)CC3)c3ccccc3)c2cc1C Show InChI InChI=1S/C32H34N4O4/c1-20-17-26-27(18-25(20)32(39)40-3)35-31(38)28(26)29(22-7-5-4-6-8-22)34-24-11-9-23(10-12-24)30(37)33-19-21-13-15-36(2)16-14-21/h4-12,17-18,21,34H,13-16,19H2,1-3H3,(H,33,37)(H,35,38)/b29-28-	PDB MMDB NCI pathway Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem		6.86	n/a	n/a	n/a	n/a	n/a	n/a	n/a	n/a
TBA									Citation and Details
					More data for this Ligand-Target Pair
Platelet-derived growth factor receptor alpha (Homo sapiens (Human))	BDBM445212 (US10669235, Example 3 | US11208381, Example 3) Show SMILES COC(=O)c1cc2NC(=O)\C(=C(/Nc3ccc(cc3)C(=O)NCC3CCN(C)CC3)c3ccccc3)c2cc1C Show InChI InChI=1S/C32H34N4O4/c1-20-17-26-27(18-25(20)32(39)40-3)35-31(38)28(26)29(22-7-5-4-6-8-22)34-24-11-9-23(10-12-24)30(37)33-19-21-13-15-36(2)16-14-21/h4-12,17-18,21,34H,13-16,19H2,1-3H3,(H,33,37)(H,35,38)/b29-28-	PDB KEGG UniProtKB/SwissProt DrugBank antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	10.7	n/a	n/a	n/a	n/a	n/a	n/a	n/a	n/a
RESPIVERT LIMITED US Patent					Assay Description The inhibitory activities of compounds of the invention against PDGFRα (PDGFRα Kinase Enzyme System: Promega), were evaluated by mixing the...				US Patent US10669235 (2020)
					More data for this Ligand-Target Pair
Platelet-derived growth factor receptor alpha (Homo sapiens (Human))	BDBM445212 (US10669235, Example 3 | US11208381, Example 3) Show SMILES COC(=O)c1cc2NC(=O)\C(=C(/Nc3ccc(cc3)C(=O)NCC3CCN(C)CC3)c3ccccc3)c2cc1C Show InChI InChI=1S/C32H34N4O4/c1-20-17-26-27(18-25(20)32(39)40-3)35-31(38)28(26)29(22-7-5-4-6-8-22)34-24-11-9-23(10-12-24)30(37)33-19-21-13-15-36(2)16-14-21/h4-12,17-18,21,34H,13-16,19H2,1-3H3,(H,33,37)(H,35,38)/b29-28-	PDB KEGG UniProtKB/SwissProt DrugBank antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem		10.7	n/a	n/a	n/a	n/a	n/a	n/a	n/a	n/a
TBA									Citation and Details
					More data for this Ligand-Target Pair
Fibroblast growth factor receptor 3 (Homo sapiens (Human))	BDBM445212 (US10669235, Example 3 | US11208381, Example 3) Show SMILES COC(=O)c1cc2NC(=O)\C(=C(/Nc3ccc(cc3)C(=O)NCC3CCN(C)CC3)c3ccccc3)c2cc1C Show InChI InChI=1S/C32H34N4O4/c1-20-17-26-27(18-25(20)32(39)40-3)35-31(38)28(26)29(22-7-5-4-6-8-22)34-24-11-9-23(10-12-24)30(37)33-19-21-13-15-36(2)16-14-21/h4-12,17-18,21,34H,13-16,19H2,1-3H3,(H,33,37)(H,35,38)/b29-28-	PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem		12.9	n/a	n/a	n/a	n/a	n/a	n/a	n/a	n/a
TBA									Citation and Details
					More data for this Ligand-Target Pair
Fibroblast growth factor receptor 3 (Homo sapiens (Human))	BDBM445212 (US10669235, Example 3 | US11208381, Example 3) Show SMILES COC(=O)c1cc2NC(=O)\C(=C(/Nc3ccc(cc3)C(=O)NCC3CCN(C)CC3)c3ccccc3)c2cc1C Show InChI InChI=1S/C32H34N4O4/c1-20-17-26-27(18-25(20)32(39)40-3)35-31(38)28(26)29(22-7-5-4-6-8-22)34-24-11-9-23(10-12-24)30(37)33-19-21-13-15-36(2)16-14-21/h4-12,17-18,21,34H,13-16,19H2,1-3H3,(H,33,37)(H,35,38)/b29-28-	PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	12.9	n/a	n/a	n/a	n/a	n/a	n/a	n/a	n/a
RESPIVERT LIMITED US Patent					Assay Description The inhibitory activities of compounds of the invention against FGFR3 (FGFR3 Kinase Enzyme System: Promega), were evaluated by mixing the FGFR3 prote...				US Patent US10669235 (2020)
					More data for this Ligand-Target Pair
Vascular endothelial growth factor receptor 2 (Homo sapiens (Human))	BDBM445212 (US10669235, Example 3 | US11208381, Example 3) Show SMILES COC(=O)c1cc2NC(=O)\C(=C(/Nc3ccc(cc3)C(=O)NCC3CCN(C)CC3)c3ccccc3)c2cc1C Show InChI InChI=1S/C32H34N4O4/c1-20-17-26-27(18-25(20)32(39)40-3)35-31(38)28(26)29(22-7-5-4-6-8-22)34-24-11-9-23(10-12-24)30(37)33-19-21-13-15-36(2)16-14-21/h4-12,17-18,21,34H,13-16,19H2,1-3H3,(H,33,37)(H,35,38)/b29-28-	PDB MMDB NCI pathway Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem		27.7	n/a	n/a	n/a	n/a	n/a	n/a	n/a	n/a
TBA									Citation and Details
					More data for this Ligand-Target Pair
Vascular endothelial growth factor receptor 2 (Homo sapiens (Human))	BDBM445212 (US10669235, Example 3 | US11208381, Example 3) Show SMILES COC(=O)c1cc2NC(=O)\C(=C(/Nc3ccc(cc3)C(=O)NCC3CCN(C)CC3)c3ccccc3)c2cc1C Show InChI InChI=1S/C32H34N4O4/c1-20-17-26-27(18-25(20)32(39)40-3)35-31(38)28(26)29(22-7-5-4-6-8-22)34-24-11-9-23(10-12-24)30(37)33-19-21-13-15-36(2)16-14-21/h4-12,17-18,21,34H,13-16,19H2,1-3H3,(H,33,37)(H,35,38)/b29-28-	PDB MMDB NCI pathway Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	27.7	n/a	n/a	n/a	n/a	n/a	n/a	n/a	n/a
RESPIVERT LIMITED US Patent					Assay Description The inhibitory activities of compounds of the invention against VEGFR2 (VEGFR2 Kinase Enzyme System: Promega), were evaluated by mixing the VEGFR2 pr...				US Patent US10669235 (2020)
					More data for this Ligand-Target Pair
Fibroblast growth factor receptor 1 (Homo sapiens (Human))	BDBM445212 (US10669235, Example 3 | US11208381, Example 3) Show SMILES COC(=O)c1cc2NC(=O)\C(=C(/Nc3ccc(cc3)C(=O)NCC3CCN(C)CC3)c3ccccc3)c2cc1C Show InChI InChI=1S/C32H34N4O4/c1-20-17-26-27(18-25(20)32(39)40-3)35-31(38)28(26)29(22-7-5-4-6-8-22)34-24-11-9-23(10-12-24)30(37)33-19-21-13-15-36(2)16-14-21/h4-12,17-18,21,34H,13-16,19H2,1-3H3,(H,33,37)(H,35,38)/b29-28-	PDB MMDB NCI pathway Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	34.1	n/a	n/a	n/a	n/a	n/a	n/a	n/a	n/a
RESPIVERT LIMITED US Patent					Assay Description The inhibitory activities of compounds of the invention against FGFR1 (FGFR1 Kinase Enzyme System: Promega), were evaluated by mixing the FGFR1 prote...				US Patent US10669235 (2020)
					More data for this Ligand-Target Pair
Fibroblast growth factor receptor 1 (Homo sapiens (Human))	BDBM445212 (US10669235, Example 3 | US11208381, Example 3) Show SMILES COC(=O)c1cc2NC(=O)\C(=C(/Nc3ccc(cc3)C(=O)NCC3CCN(C)CC3)c3ccccc3)c2cc1C Show InChI InChI=1S/C32H34N4O4/c1-20-17-26-27(18-25(20)32(39)40-3)35-31(38)28(26)29(22-7-5-4-6-8-22)34-24-11-9-23(10-12-24)30(37)33-19-21-13-15-36(2)16-14-21/h4-12,17-18,21,34H,13-16,19H2,1-3H3,(H,33,37)(H,35,38)/b29-28-	PDB MMDB NCI pathway Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem		34.1	n/a	n/a	n/a	n/a	n/a	n/a	n/a	n/a
TBA									Citation and Details
					More data for this Ligand-Target Pair
Vascular endothelial growth factor receptor 1 (Homo sapiens (Human))	BDBM445212 (US10669235, Example 3 | US11208381, Example 3) Show SMILES COC(=O)c1cc2NC(=O)\C(=C(/Nc3ccc(cc3)C(=O)NCC3CCN(C)CC3)c3ccccc3)c2cc1C Show InChI InChI=1S/C32H34N4O4/c1-20-17-26-27(18-25(20)32(39)40-3)35-31(38)28(26)29(22-7-5-4-6-8-22)34-24-11-9-23(10-12-24)30(37)33-19-21-13-15-36(2)16-14-21/h4-12,17-18,21,34H,13-16,19H2,1-3H3,(H,33,37)(H,35,38)/b29-28-	PDB MMDB KEGG UniProtKB/SwissProt UniProtKB/TrEMBL B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	73.1	n/a	n/a	n/a	n/a	n/a	n/a	n/a	n/a
RESPIVERT LIMITED US Patent					Assay Description The inhibitory activities of compounds of the invention against VEGFR1 (VEGFR1 Kinase Enzyme System: Promega), were evaluated by mixing the VEGFR1 pr...				US Patent US10669235 (2020)
					More data for this Ligand-Target Pair
Vascular endothelial growth factor receptor 1 and 2 (Flt-1 and KDR) (Homo sapiens (Human))	BDBM445212 (US10669235, Example 3 | US11208381, Example 3) Show SMILES COC(=O)c1cc2NC(=O)\C(=C(/Nc3ccc(cc3)C(=O)NCC3CCN(C)CC3)c3ccccc3)c2cc1C Show InChI InChI=1S/C32H34N4O4/c1-20-17-26-27(18-25(20)32(39)40-3)35-31(38)28(26)29(22-7-5-4-6-8-22)34-24-11-9-23(10-12-24)30(37)33-19-21-13-15-36(2)16-14-21/h4-12,17-18,21,34H,13-16,19H2,1-3H3,(H,33,37)(H,35,38)/b29-28-	PDB MMDB KEGG UniProtKB/SwissProt UniProtKB/TrEMBL B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem		73.1	n/a	n/a	n/a	n/a	n/a	n/a	n/a	n/a
TBA									Citation and Details
					More data for this Ligand-Target Pair