BDBM445215 US10669235, Example 6

SMILES: COC(=O)c1cc2NC(=O)\C(=C(/Nc3ccc(cc3)C(=O)NCCN3CCC(CC3)N(C)C)c3ccccc3)c2cc1C

InChI Key: InChIKey=YYICSPRZBVQPTF-KTMFPKCZSA-N

Data: 6 KI

Find this compound or compounds like it in BindingDB or PDB:

Substructure Similarity at least:  must be >=0.5 Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 6 hits for monomerid = 445215   

Target/Host (Institution)	Ligand	Target/Host Links	Ligand Links	Trg + Lig Links	Ki nM	ΔG° kcal/mole	IC50 nM	Kd nM	EC50/IC50 nM	koff s-1	kon M-1s-1	pH	Temp °C
Fibroblast growth factor receptor 3 (Homo sapiens (Human))	BDBM445215 (US10669235, Example 6) Show SMILES COC(=O)c1cc2NC(=O)\C(=C(/Nc3ccc(cc3)C(=O)NCCN3CCC(CC3)N(C)C)c3ccccc3)c2cc1C Show InChI InChI=1S/C34H39N5O4/c1-22-20-28-29(21-27(22)34(42)43-4)37-33(41)30(28)31(23-8-6-5-7-9-23)36-25-12-10-24(11-13-25)32(40)35-16-19-39-17-14-26(15-18-39)38(2)3/h5-13,20-21,26,36H,14-19H2,1-4H3,(H,35,40)(H,37,41)/b31-30-	PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	7.35	n/a	n/a	n/a	n/a	n/a	n/a	n/a	n/a
RESPIVERT LIMITED US Patent					Assay Description The inhibitory activities of compounds of the invention against FGFR3 (FGFR3 Kinase Enzyme System: Promega), were evaluated by mixing the FGFR3 prote...				US Patent US10669235 (2020)
					More data for this Ligand-Target Pair
Platelet-derived growth factor receptor alpha (Homo sapiens (Human))	BDBM445215 (US10669235, Example 6) Show SMILES COC(=O)c1cc2NC(=O)\C(=C(/Nc3ccc(cc3)C(=O)NCCN3CCC(CC3)N(C)C)c3ccccc3)c2cc1C Show InChI InChI=1S/C34H39N5O4/c1-22-20-28-29(21-27(22)34(42)43-4)37-33(41)30(28)31(23-8-6-5-7-9-23)36-25-12-10-24(11-13-25)32(40)35-16-19-39-17-14-26(15-18-39)38(2)3/h5-13,20-21,26,36H,14-19H2,1-4H3,(H,35,40)(H,37,41)/b31-30-	PDB KEGG UniProtKB/SwissProt DrugBank antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	9.41	n/a	n/a	n/a	n/a	n/a	n/a	n/a	n/a
RESPIVERT LIMITED US Patent					Assay Description The inhibitory activities of compounds of the invention against PDGFRα (PDGFRα Kinase Enzyme System: Promega), were evaluated by mixing the...				US Patent US10669235 (2020)
					More data for this Ligand-Target Pair
Platelet-derived growth factor receptor beta (Homo sapiens (Human))	BDBM445215 (US10669235, Example 6) Show SMILES COC(=O)c1cc2NC(=O)\C(=C(/Nc3ccc(cc3)C(=O)NCCN3CCC(CC3)N(C)C)c3ccccc3)c2cc1C Show InChI InChI=1S/C34H39N5O4/c1-22-20-28-29(21-27(22)34(42)43-4)37-33(41)30(28)31(23-8-6-5-7-9-23)36-25-12-10-24(11-13-25)32(40)35-16-19-39-17-14-26(15-18-39)38(2)3/h5-13,20-21,26,36H,14-19H2,1-4H3,(H,35,40)(H,37,41)/b31-30-	PDB MMDB NCI pathway Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	10.3	n/a	n/a	n/a	n/a	n/a	n/a	n/a	n/a
RESPIVERT LIMITED US Patent					Assay Description The inhibitory activities of compounds of the invention against PDGFRβ (PDGFRβ Kinase Enzyme System: Promega), were evaluated by mixing the...				US Patent US10669235 (2020)
					More data for this Ligand-Target Pair
Vascular endothelial growth factor receptor 2 (Homo sapiens (Human))	BDBM445215 (US10669235, Example 6) Show SMILES COC(=O)c1cc2NC(=O)\C(=C(/Nc3ccc(cc3)C(=O)NCCN3CCC(CC3)N(C)C)c3ccccc3)c2cc1C Show InChI InChI=1S/C34H39N5O4/c1-22-20-28-29(21-27(22)34(42)43-4)37-33(41)30(28)31(23-8-6-5-7-9-23)36-25-12-10-24(11-13-25)32(40)35-16-19-39-17-14-26(15-18-39)38(2)3/h5-13,20-21,26,36H,14-19H2,1-4H3,(H,35,40)(H,37,41)/b31-30-	PDB MMDB NCI pathway Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	21.2	n/a	n/a	n/a	n/a	n/a	n/a	n/a	n/a
RESPIVERT LIMITED US Patent					Assay Description The inhibitory activities of compounds of the invention against VEGFR2 (VEGFR2 Kinase Enzyme System: Promega), were evaluated by mixing the VEGFR2 pr...				US Patent US10669235 (2020)
					More data for this Ligand-Target Pair
Fibroblast growth factor receptor 1 (Homo sapiens (Human))	BDBM445215 (US10669235, Example 6) Show SMILES COC(=O)c1cc2NC(=O)\C(=C(/Nc3ccc(cc3)C(=O)NCCN3CCC(CC3)N(C)C)c3ccccc3)c2cc1C Show InChI InChI=1S/C34H39N5O4/c1-22-20-28-29(21-27(22)34(42)43-4)37-33(41)30(28)31(23-8-6-5-7-9-23)36-25-12-10-24(11-13-25)32(40)35-16-19-39-17-14-26(15-18-39)38(2)3/h5-13,20-21,26,36H,14-19H2,1-4H3,(H,35,40)(H,37,41)/b31-30-	PDB MMDB NCI pathway Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	28.4	n/a	n/a	n/a	n/a	n/a	n/a	n/a	n/a
RESPIVERT LIMITED US Patent					Assay Description The inhibitory activities of compounds of the invention against FGFR1 (FGFR1 Kinase Enzyme System: Promega), were evaluated by mixing the FGFR1 prote...				US Patent US10669235 (2020)
					More data for this Ligand-Target Pair
Vascular endothelial growth factor receptor 1 (Homo sapiens (Human))	BDBM445215 (US10669235, Example 6) Show SMILES COC(=O)c1cc2NC(=O)\C(=C(/Nc3ccc(cc3)C(=O)NCCN3CCC(CC3)N(C)C)c3ccccc3)c2cc1C Show InChI InChI=1S/C34H39N5O4/c1-22-20-28-29(21-27(22)34(42)43-4)37-33(41)30(28)31(23-8-6-5-7-9-23)36-25-12-10-24(11-13-25)32(40)35-16-19-39-17-14-26(15-18-39)38(2)3/h5-13,20-21,26,36H,14-19H2,1-4H3,(H,35,40)(H,37,41)/b31-30-	PDB MMDB KEGG UniProtKB/SwissProt UniProtKB/TrEMBL B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	80.8	n/a	n/a	n/a	n/a	n/a	n/a	n/a	n/a
RESPIVERT LIMITED US Patent					Assay Description The inhibitory activities of compounds of the invention against VEGFR1 (VEGFR1 Kinase Enzyme System: Promega), were evaluated by mixing the VEGFR1 pr...				US Patent US10669235 (2020)
					More data for this Ligand-Target Pair