Found 12 hits for monomerid = 445217 Target/Host (Institution) | Ligand | Target/Host Links | Ligand Links | Trg + Lig Links | Ki nM | ΔG° kcal/mole | IC50 nM | Kd nM | EC50/IC50 nM | koff s-1 | kon M-1s-1 | pH | Temp °C |
Platelet-derived growth factor receptor beta
(Homo sapiens (Human)) | BDBM445217
(US10669235, Example 8 | US11208381, Example 8)Show SMILES COC(=O)c1cc2NC(=O)\C(=C(/Nc3ccc(cc3)C(=O)NCC(=O)N3CCN(C)CC3)c3ccccc3)c2cc1C Show InChI InChI=1S/C32H33N5O5/c1-20-17-25-26(18-24(20)32(41)42-3)35-31(40)28(25)29(21-7-5-4-6-8-21)34-23-11-9-22(10-12-23)30(39)33-19-27(38)37-15-13-36(2)14-16-37/h4-12,17-18,34H,13-16,19H2,1-3H3,(H,33,39)(H,35,40)/b29-28- | PDB MMDB
NCI pathway Reactome pathway KEGG
UniProtKB/SwissProt
B.MOAD DrugBank antibodypedia GoogleScholar AffyNet
| PC cid PC sid UniChem
| US Patent
| 8.12 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
RESPIVERT LIMITED
US Patent
| Assay Description The inhibitory activities of compounds of the invention against PDGFRβ (PDGFRβ Kinase Enzyme System: Promega), were evaluated by mixing the... |
US Patent US10669235 (2020)
|
More data for this Ligand-Target Pair | |
VHL/PDGFRB
(Homo sapiens (Human)) | BDBM445217
(US10669235, Example 8 | US11208381, Example 8)Show SMILES COC(=O)c1cc2NC(=O)\C(=C(/Nc3ccc(cc3)C(=O)NCC(=O)N3CCN(C)CC3)c3ccccc3)c2cc1C Show InChI InChI=1S/C32H33N5O5/c1-20-17-25-26(18-24(20)32(41)42-3)35-31(40)28(25)29(21-7-5-4-6-8-21)34-23-11-9-22(10-12-23)30(39)33-19-27(38)37-15-13-36(2)14-16-37/h4-12,17-18,34H,13-16,19H2,1-3H3,(H,33,39)(H,35,40)/b29-28- | PDB MMDB
NCI pathway Reactome pathway KEGG
UniProtKB/SwissProt
B.MOAD DrugBank antibodypedia GoogleScholar AffyNet
| PC cid PC sid UniChem
| | 8.12 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
TBA
| |
Citation and Details
|
More data for this Ligand-Target Pair | |
Platelet-derived growth factor receptor alpha
(Homo sapiens (Human)) | BDBM445217
(US10669235, Example 8 | US11208381, Example 8)Show SMILES COC(=O)c1cc2NC(=O)\C(=C(/Nc3ccc(cc3)C(=O)NCC(=O)N3CCN(C)CC3)c3ccccc3)c2cc1C Show InChI InChI=1S/C32H33N5O5/c1-20-17-25-26(18-24(20)32(41)42-3)35-31(40)28(25)29(21-7-5-4-6-8-21)34-23-11-9-22(10-12-23)30(39)33-19-27(38)37-15-13-36(2)14-16-37/h4-12,17-18,34H,13-16,19H2,1-3H3,(H,33,39)(H,35,40)/b29-28- | PDB
KEGG
UniProtKB/SwissProt
DrugBank antibodypedia GoogleScholar AffyNet
| PC cid PC sid UniChem
| US Patent
| 10.9 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
RESPIVERT LIMITED
US Patent
| Assay Description The inhibitory activities of compounds of the invention against PDGFRα (PDGFRα Kinase Enzyme System: Promega), were evaluated by mixing the... |
US Patent US10669235 (2020)
|
More data for this Ligand-Target Pair | |
Platelet-derived growth factor receptor alpha
(Homo sapiens (Human)) | BDBM445217
(US10669235, Example 8 | US11208381, Example 8)Show SMILES COC(=O)c1cc2NC(=O)\C(=C(/Nc3ccc(cc3)C(=O)NCC(=O)N3CCN(C)CC3)c3ccccc3)c2cc1C Show InChI InChI=1S/C32H33N5O5/c1-20-17-25-26(18-24(20)32(41)42-3)35-31(40)28(25)29(21-7-5-4-6-8-21)34-23-11-9-22(10-12-23)30(39)33-19-27(38)37-15-13-36(2)14-16-37/h4-12,17-18,34H,13-16,19H2,1-3H3,(H,33,39)(H,35,40)/b29-28- | PDB
KEGG
UniProtKB/SwissProt
DrugBank antibodypedia GoogleScholar AffyNet
| PC cid PC sid UniChem
| | 10.9 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
TBA
| |
Citation and Details
|
More data for this Ligand-Target Pair | |
Fibroblast growth factor receptor 3
(Homo sapiens (Human)) | BDBM445217
(US10669235, Example 8 | US11208381, Example 8)Show SMILES COC(=O)c1cc2NC(=O)\C(=C(/Nc3ccc(cc3)C(=O)NCC(=O)N3CCN(C)CC3)c3ccccc3)c2cc1C Show InChI InChI=1S/C32H33N5O5/c1-20-17-25-26(18-24(20)32(41)42-3)35-31(40)28(25)29(21-7-5-4-6-8-21)34-23-11-9-22(10-12-23)30(39)33-19-27(38)37-15-13-36(2)14-16-37/h4-12,17-18,34H,13-16,19H2,1-3H3,(H,33,39)(H,35,40)/b29-28- | PDB MMDB
Reactome pathway KEGG
UniProtKB/SwissProt
B.MOAD DrugBank antibodypedia GoogleScholar AffyNet
| PC cid PC sid UniChem
| | 17.1 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
TBA
| |
Citation and Details
|
More data for this Ligand-Target Pair | |
Fibroblast growth factor receptor 3
(Homo sapiens (Human)) | BDBM445217
(US10669235, Example 8 | US11208381, Example 8)Show SMILES COC(=O)c1cc2NC(=O)\C(=C(/Nc3ccc(cc3)C(=O)NCC(=O)N3CCN(C)CC3)c3ccccc3)c2cc1C Show InChI InChI=1S/C32H33N5O5/c1-20-17-25-26(18-24(20)32(41)42-3)35-31(40)28(25)29(21-7-5-4-6-8-21)34-23-11-9-22(10-12-23)30(39)33-19-27(38)37-15-13-36(2)14-16-37/h4-12,17-18,34H,13-16,19H2,1-3H3,(H,33,39)(H,35,40)/b29-28- | PDB MMDB
Reactome pathway KEGG
UniProtKB/SwissProt
B.MOAD DrugBank antibodypedia GoogleScholar AffyNet
| PC cid PC sid UniChem
| US Patent
| 17.1 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
RESPIVERT LIMITED
US Patent
| Assay Description The inhibitory activities of compounds of the invention against FGFR3 (FGFR3 Kinase Enzyme System: Promega), were evaluated by mixing the FGFR3 prote... |
US Patent US10669235 (2020)
|
More data for this Ligand-Target Pair | |
Vascular endothelial growth factor receptor 2
(Homo sapiens (Human)) | BDBM445217
(US10669235, Example 8 | US11208381, Example 8)Show SMILES COC(=O)c1cc2NC(=O)\C(=C(/Nc3ccc(cc3)C(=O)NCC(=O)N3CCN(C)CC3)c3ccccc3)c2cc1C Show InChI InChI=1S/C32H33N5O5/c1-20-17-25-26(18-24(20)32(41)42-3)35-31(40)28(25)29(21-7-5-4-6-8-21)34-23-11-9-22(10-12-23)30(39)33-19-27(38)37-15-13-36(2)14-16-37/h4-12,17-18,34H,13-16,19H2,1-3H3,(H,33,39)(H,35,40)/b29-28- | PDB MMDB
NCI pathway Reactome pathway KEGG
UniProtKB/SwissProt
B.MOAD DrugBank antibodypedia GoogleScholar AffyNet
| PC cid PC sid UniChem
| | 18.8 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
TBA
| |
Citation and Details
|
More data for this Ligand-Target Pair | |
Vascular endothelial growth factor receptor 2
(Homo sapiens (Human)) | BDBM445217
(US10669235, Example 8 | US11208381, Example 8)Show SMILES COC(=O)c1cc2NC(=O)\C(=C(/Nc3ccc(cc3)C(=O)NCC(=O)N3CCN(C)CC3)c3ccccc3)c2cc1C Show InChI InChI=1S/C32H33N5O5/c1-20-17-25-26(18-24(20)32(41)42-3)35-31(40)28(25)29(21-7-5-4-6-8-21)34-23-11-9-22(10-12-23)30(39)33-19-27(38)37-15-13-36(2)14-16-37/h4-12,17-18,34H,13-16,19H2,1-3H3,(H,33,39)(H,35,40)/b29-28- | PDB MMDB
NCI pathway Reactome pathway KEGG
UniProtKB/SwissProt
B.MOAD DrugBank antibodypedia GoogleScholar AffyNet
| PC cid PC sid UniChem
| US Patent
| 18.8 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
RESPIVERT LIMITED
US Patent
| Assay Description The inhibitory activities of compounds of the invention against VEGFR2 (VEGFR2 Kinase Enzyme System: Promega), were evaluated by mixing the VEGFR2 pr... |
US Patent US10669235 (2020)
|
More data for this Ligand-Target Pair | |
Fibroblast growth factor receptor 1
(Homo sapiens (Human)) | BDBM445217
(US10669235, Example 8 | US11208381, Example 8)Show SMILES COC(=O)c1cc2NC(=O)\C(=C(/Nc3ccc(cc3)C(=O)NCC(=O)N3CCN(C)CC3)c3ccccc3)c2cc1C Show InChI InChI=1S/C32H33N5O5/c1-20-17-25-26(18-24(20)32(41)42-3)35-31(40)28(25)29(21-7-5-4-6-8-21)34-23-11-9-22(10-12-23)30(39)33-19-27(38)37-15-13-36(2)14-16-37/h4-12,17-18,34H,13-16,19H2,1-3H3,(H,33,39)(H,35,40)/b29-28- | PDB MMDB
NCI pathway Reactome pathway KEGG
UniProtKB/SwissProt
B.MOAD DrugBank antibodypedia GoogleScholar AffyNet
| PC cid PC sid UniChem
| US Patent
| 41.8 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
RESPIVERT LIMITED
US Patent
| Assay Description The inhibitory activities of compounds of the invention against FGFR1 (FGFR1 Kinase Enzyme System: Promega), were evaluated by mixing the FGFR1 prote... |
US Patent US10669235 (2020)
|
More data for this Ligand-Target Pair | |
Fibroblast growth factor receptor 1
(Homo sapiens (Human)) | BDBM445217
(US10669235, Example 8 | US11208381, Example 8)Show SMILES COC(=O)c1cc2NC(=O)\C(=C(/Nc3ccc(cc3)C(=O)NCC(=O)N3CCN(C)CC3)c3ccccc3)c2cc1C Show InChI InChI=1S/C32H33N5O5/c1-20-17-25-26(18-24(20)32(41)42-3)35-31(40)28(25)29(21-7-5-4-6-8-21)34-23-11-9-22(10-12-23)30(39)33-19-27(38)37-15-13-36(2)14-16-37/h4-12,17-18,34H,13-16,19H2,1-3H3,(H,33,39)(H,35,40)/b29-28- | PDB MMDB
NCI pathway Reactome pathway KEGG
UniProtKB/SwissProt
B.MOAD DrugBank antibodypedia GoogleScholar AffyNet
| PC cid PC sid UniChem
| | 41.8 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
TBA
| |
Citation and Details
|
More data for this Ligand-Target Pair | |
Vascular endothelial growth factor receptor 1
(Homo sapiens (Human)) | BDBM445217
(US10669235, Example 8 | US11208381, Example 8)Show SMILES COC(=O)c1cc2NC(=O)\C(=C(/Nc3ccc(cc3)C(=O)NCC(=O)N3CCN(C)CC3)c3ccccc3)c2cc1C Show InChI InChI=1S/C32H33N5O5/c1-20-17-25-26(18-24(20)32(41)42-3)35-31(40)28(25)29(21-7-5-4-6-8-21)34-23-11-9-22(10-12-23)30(39)33-19-27(38)37-15-13-36(2)14-16-37/h4-12,17-18,34H,13-16,19H2,1-3H3,(H,33,39)(H,35,40)/b29-28- | PDB MMDB
KEGG
UniProtKB/SwissProt UniProtKB/TrEMBL
B.MOAD DrugBank antibodypedia GoogleScholar AffyNet
| PC cid PC sid UniChem
| US Patent
| 150 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
RESPIVERT LIMITED
US Patent
| Assay Description The inhibitory activities of compounds of the invention against VEGFR1 (VEGFR1 Kinase Enzyme System: Promega), were evaluated by mixing the VEGFR1 pr... |
US Patent US10669235 (2020)
|
More data for this Ligand-Target Pair | |
Vascular endothelial growth factor receptor 1 and 2 (Flt-1 and KDR)
(Homo sapiens (Human)) | BDBM445217
(US10669235, Example 8 | US11208381, Example 8)Show SMILES COC(=O)c1cc2NC(=O)\C(=C(/Nc3ccc(cc3)C(=O)NCC(=O)N3CCN(C)CC3)c3ccccc3)c2cc1C Show InChI InChI=1S/C32H33N5O5/c1-20-17-25-26(18-24(20)32(41)42-3)35-31(40)28(25)29(21-7-5-4-6-8-21)34-23-11-9-22(10-12-23)30(39)33-19-27(38)37-15-13-36(2)14-16-37/h4-12,17-18,34H,13-16,19H2,1-3H3,(H,33,39)(H,35,40)/b29-28- | PDB MMDB
KEGG
UniProtKB/SwissProt UniProtKB/TrEMBL
B.MOAD DrugBank antibodypedia GoogleScholar AffyNet
| PC cid PC sid UniChem
| | 150 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
TBA
| |
Citation and Details
|
More data for this Ligand-Target Pair | |