Found 12 hits for monomerid = 445220 Target/Host (Institution) | Ligand | Target/Host Links | Ligand Links | Trg + Lig Links | Ki nM | ΔG° kcal/mole | IC50 nM | Kd nM | EC50/IC50 nM | koff s-1 | kon M-1s-1 | pH | Temp °C |
Vascular endothelial growth factor receptor 2
(Homo sapiens (Human)) | BDBM445220
(US10669235, Example 11 | US11208381, Example 11)Show SMILES CNC(=O)CN1CCN(CC1)C(=O)c1ccc(N\C(=C2/C(=O)Nc3cc(C(=O)OC)c(C)cc23)c2ccccc2)cc1 Show InChI InChI=1S/C32H33N5O5/c1-20-17-25-26(18-24(20)32(41)42-3)35-30(39)28(25)29(21-7-5-4-6-8-21)34-23-11-9-22(10-12-23)31(40)37-15-13-36(14-16-37)19-27(38)33-2/h4-12,17-18,34H,13-16,19H2,1-3H3,(H,33,38)(H,35,39)/b29-28- | PDB MMDB
NCI pathway Reactome pathway KEGG
UniProtKB/SwissProt
B.MOAD DrugBank antibodypedia GoogleScholar AffyNet
| PC cid PC sid UniChem
| US Patent
| 5.06 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
RESPIVERT LIMITED
US Patent
| Assay Description The inhibitory activities of compounds of the invention against VEGFR2 (VEGFR2 Kinase Enzyme System: Promega), were evaluated by mixing the VEGFR2 pr... |
US Patent US10669235 (2020)
|
More data for this Ligand-Target Pair | |
Vascular endothelial growth factor receptor 2
(Homo sapiens (Human)) | BDBM445220
(US10669235, Example 11 | US11208381, Example 11)Show SMILES CNC(=O)CN1CCN(CC1)C(=O)c1ccc(N\C(=C2/C(=O)Nc3cc(C(=O)OC)c(C)cc23)c2ccccc2)cc1 Show InChI InChI=1S/C32H33N5O5/c1-20-17-25-26(18-24(20)32(41)42-3)35-30(39)28(25)29(21-7-5-4-6-8-21)34-23-11-9-22(10-12-23)31(40)37-15-13-36(14-16-37)19-27(38)33-2/h4-12,17-18,34H,13-16,19H2,1-3H3,(H,33,38)(H,35,39)/b29-28- | PDB MMDB
NCI pathway Reactome pathway KEGG
UniProtKB/SwissProt
B.MOAD DrugBank antibodypedia GoogleScholar AffyNet
| PC cid PC sid UniChem
| | 5.06 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
TBA
| |
Citation and Details
|
More data for this Ligand-Target Pair | |
Platelet-derived growth factor receptor beta
(Homo sapiens (Human)) | BDBM445220
(US10669235, Example 11 | US11208381, Example 11)Show SMILES CNC(=O)CN1CCN(CC1)C(=O)c1ccc(N\C(=C2/C(=O)Nc3cc(C(=O)OC)c(C)cc23)c2ccccc2)cc1 Show InChI InChI=1S/C32H33N5O5/c1-20-17-25-26(18-24(20)32(41)42-3)35-30(39)28(25)29(21-7-5-4-6-8-21)34-23-11-9-22(10-12-23)31(40)37-15-13-36(14-16-37)19-27(38)33-2/h4-12,17-18,34H,13-16,19H2,1-3H3,(H,33,38)(H,35,39)/b29-28- | PDB MMDB
NCI pathway Reactome pathway KEGG
UniProtKB/SwissProt
B.MOAD DrugBank antibodypedia GoogleScholar AffyNet
| PC cid PC sid UniChem
| US Patent
| 10.6 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
RESPIVERT LIMITED
US Patent
| Assay Description The inhibitory activities of compounds of the invention against PDGFRβ (PDGFRβ Kinase Enzyme System: Promega), were evaluated by mixing the... |
US Patent US10669235 (2020)
|
More data for this Ligand-Target Pair | |
VHL/PDGFRB
(Homo sapiens (Human)) | BDBM445220
(US10669235, Example 11 | US11208381, Example 11)Show SMILES CNC(=O)CN1CCN(CC1)C(=O)c1ccc(N\C(=C2/C(=O)Nc3cc(C(=O)OC)c(C)cc23)c2ccccc2)cc1 Show InChI InChI=1S/C32H33N5O5/c1-20-17-25-26(18-24(20)32(41)42-3)35-30(39)28(25)29(21-7-5-4-6-8-21)34-23-11-9-22(10-12-23)31(40)37-15-13-36(14-16-37)19-27(38)33-2/h4-12,17-18,34H,13-16,19H2,1-3H3,(H,33,38)(H,35,39)/b29-28- | PDB MMDB
NCI pathway Reactome pathway KEGG
UniProtKB/SwissProt
B.MOAD DrugBank antibodypedia GoogleScholar AffyNet
| PC cid PC sid UniChem
| | 10.6 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
TBA
| |
Citation and Details
|
More data for this Ligand-Target Pair | |
Platelet-derived growth factor receptor alpha
(Homo sapiens (Human)) | BDBM445220
(US10669235, Example 11 | US11208381, Example 11)Show SMILES CNC(=O)CN1CCN(CC1)C(=O)c1ccc(N\C(=C2/C(=O)Nc3cc(C(=O)OC)c(C)cc23)c2ccccc2)cc1 Show InChI InChI=1S/C32H33N5O5/c1-20-17-25-26(18-24(20)32(41)42-3)35-30(39)28(25)29(21-7-5-4-6-8-21)34-23-11-9-22(10-12-23)31(40)37-15-13-36(14-16-37)19-27(38)33-2/h4-12,17-18,34H,13-16,19H2,1-3H3,(H,33,38)(H,35,39)/b29-28- | PDB
KEGG
UniProtKB/SwissProt
DrugBank antibodypedia GoogleScholar AffyNet
| PC cid PC sid UniChem
| | 12.3 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
TBA
| |
Citation and Details
|
More data for this Ligand-Target Pair | |
Platelet-derived growth factor receptor alpha
(Homo sapiens (Human)) | BDBM445220
(US10669235, Example 11 | US11208381, Example 11)Show SMILES CNC(=O)CN1CCN(CC1)C(=O)c1ccc(N\C(=C2/C(=O)Nc3cc(C(=O)OC)c(C)cc23)c2ccccc2)cc1 Show InChI InChI=1S/C32H33N5O5/c1-20-17-25-26(18-24(20)32(41)42-3)35-30(39)28(25)29(21-7-5-4-6-8-21)34-23-11-9-22(10-12-23)31(40)37-15-13-36(14-16-37)19-27(38)33-2/h4-12,17-18,34H,13-16,19H2,1-3H3,(H,33,38)(H,35,39)/b29-28- | PDB
KEGG
UniProtKB/SwissProt
DrugBank antibodypedia GoogleScholar AffyNet
| PC cid PC sid UniChem
| US Patent
| 12.3 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
RESPIVERT LIMITED
US Patent
| Assay Description The inhibitory activities of compounds of the invention against PDGFRα (PDGFRα Kinase Enzyme System: Promega), were evaluated by mixing the... |
US Patent US10669235 (2020)
|
More data for this Ligand-Target Pair | |
Fibroblast growth factor receptor 3
(Homo sapiens (Human)) | BDBM445220
(US10669235, Example 11 | US11208381, Example 11)Show SMILES CNC(=O)CN1CCN(CC1)C(=O)c1ccc(N\C(=C2/C(=O)Nc3cc(C(=O)OC)c(C)cc23)c2ccccc2)cc1 Show InChI InChI=1S/C32H33N5O5/c1-20-17-25-26(18-24(20)32(41)42-3)35-30(39)28(25)29(21-7-5-4-6-8-21)34-23-11-9-22(10-12-23)31(40)37-15-13-36(14-16-37)19-27(38)33-2/h4-12,17-18,34H,13-16,19H2,1-3H3,(H,33,38)(H,35,39)/b29-28- | PDB MMDB
Reactome pathway KEGG
UniProtKB/SwissProt
B.MOAD DrugBank antibodypedia GoogleScholar AffyNet
| PC cid PC sid UniChem
| US Patent
| 14.1 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
RESPIVERT LIMITED
US Patent
| Assay Description The inhibitory activities of compounds of the invention against FGFR3 (FGFR3 Kinase Enzyme System: Promega), were evaluated by mixing the FGFR3 prote... |
US Patent US10669235 (2020)
|
More data for this Ligand-Target Pair | |
Fibroblast growth factor receptor 3
(Homo sapiens (Human)) | BDBM445220
(US10669235, Example 11 | US11208381, Example 11)Show SMILES CNC(=O)CN1CCN(CC1)C(=O)c1ccc(N\C(=C2/C(=O)Nc3cc(C(=O)OC)c(C)cc23)c2ccccc2)cc1 Show InChI InChI=1S/C32H33N5O5/c1-20-17-25-26(18-24(20)32(41)42-3)35-30(39)28(25)29(21-7-5-4-6-8-21)34-23-11-9-22(10-12-23)31(40)37-15-13-36(14-16-37)19-27(38)33-2/h4-12,17-18,34H,13-16,19H2,1-3H3,(H,33,38)(H,35,39)/b29-28- | PDB MMDB
Reactome pathway KEGG
UniProtKB/SwissProt
B.MOAD DrugBank antibodypedia GoogleScholar AffyNet
| PC cid PC sid UniChem
| | 14.1 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
TBA
| |
Citation and Details
|
More data for this Ligand-Target Pair | |
Fibroblast growth factor receptor 1
(Homo sapiens (Human)) | BDBM445220
(US10669235, Example 11 | US11208381, Example 11)Show SMILES CNC(=O)CN1CCN(CC1)C(=O)c1ccc(N\C(=C2/C(=O)Nc3cc(C(=O)OC)c(C)cc23)c2ccccc2)cc1 Show InChI InChI=1S/C32H33N5O5/c1-20-17-25-26(18-24(20)32(41)42-3)35-30(39)28(25)29(21-7-5-4-6-8-21)34-23-11-9-22(10-12-23)31(40)37-15-13-36(14-16-37)19-27(38)33-2/h4-12,17-18,34H,13-16,19H2,1-3H3,(H,33,38)(H,35,39)/b29-28- | PDB MMDB
NCI pathway Reactome pathway KEGG
UniProtKB/SwissProt
B.MOAD DrugBank antibodypedia GoogleScholar AffyNet
| PC cid PC sid UniChem
| US Patent
| 23.9 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
RESPIVERT LIMITED
US Patent
| Assay Description The inhibitory activities of compounds of the invention against FGFR1 (FGFR1 Kinase Enzyme System: Promega), were evaluated by mixing the FGFR1 prote... |
US Patent US10669235 (2020)
|
More data for this Ligand-Target Pair | |
Fibroblast growth factor receptor 1
(Homo sapiens (Human)) | BDBM445220
(US10669235, Example 11 | US11208381, Example 11)Show SMILES CNC(=O)CN1CCN(CC1)C(=O)c1ccc(N\C(=C2/C(=O)Nc3cc(C(=O)OC)c(C)cc23)c2ccccc2)cc1 Show InChI InChI=1S/C32H33N5O5/c1-20-17-25-26(18-24(20)32(41)42-3)35-30(39)28(25)29(21-7-5-4-6-8-21)34-23-11-9-22(10-12-23)31(40)37-15-13-36(14-16-37)19-27(38)33-2/h4-12,17-18,34H,13-16,19H2,1-3H3,(H,33,38)(H,35,39)/b29-28- | PDB MMDB
NCI pathway Reactome pathway KEGG
UniProtKB/SwissProt
B.MOAD DrugBank antibodypedia GoogleScholar AffyNet
| PC cid PC sid UniChem
| | 23.9 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
TBA
| |
Citation and Details
|
More data for this Ligand-Target Pair | |
Vascular endothelial growth factor receptor 1
(Homo sapiens (Human)) | BDBM445220
(US10669235, Example 11 | US11208381, Example 11)Show SMILES CNC(=O)CN1CCN(CC1)C(=O)c1ccc(N\C(=C2/C(=O)Nc3cc(C(=O)OC)c(C)cc23)c2ccccc2)cc1 Show InChI InChI=1S/C32H33N5O5/c1-20-17-25-26(18-24(20)32(41)42-3)35-30(39)28(25)29(21-7-5-4-6-8-21)34-23-11-9-22(10-12-23)31(40)37-15-13-36(14-16-37)19-27(38)33-2/h4-12,17-18,34H,13-16,19H2,1-3H3,(H,33,38)(H,35,39)/b29-28- | PDB MMDB
KEGG
UniProtKB/SwissProt UniProtKB/TrEMBL
B.MOAD DrugBank antibodypedia GoogleScholar AffyNet
| PC cid PC sid UniChem
| US Patent
| 90.7 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
RESPIVERT LIMITED
US Patent
| Assay Description The inhibitory activities of compounds of the invention against VEGFR1 (VEGFR1 Kinase Enzyme System: Promega), were evaluated by mixing the VEGFR1 pr... |
US Patent US10669235 (2020)
|
More data for this Ligand-Target Pair | |
Vascular endothelial growth factor receptor 1 and 2 (Flt-1 and KDR)
(Homo sapiens (Human)) | BDBM445220
(US10669235, Example 11 | US11208381, Example 11)Show SMILES CNC(=O)CN1CCN(CC1)C(=O)c1ccc(N\C(=C2/C(=O)Nc3cc(C(=O)OC)c(C)cc23)c2ccccc2)cc1 Show InChI InChI=1S/C32H33N5O5/c1-20-17-25-26(18-24(20)32(41)42-3)35-30(39)28(25)29(21-7-5-4-6-8-21)34-23-11-9-22(10-12-23)31(40)37-15-13-36(14-16-37)19-27(38)33-2/h4-12,17-18,34H,13-16,19H2,1-3H3,(H,33,38)(H,35,39)/b29-28- | PDB MMDB
KEGG
UniProtKB/SwissProt UniProtKB/TrEMBL
B.MOAD DrugBank antibodypedia GoogleScholar AffyNet
| PC cid PC sid UniChem
| | 90.7 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
TBA
| |
Citation and Details
|
More data for this Ligand-Target Pair | |