Found 12 hits for monomerid = 445227 Target/Host (Institution) | Ligand | Target/Host Links | Ligand Links | Trg + Lig Links | Ki nM | ΔG° kcal/mole | IC50 nM | Kd nM | EC50/IC50 nM | koff s-1 | kon M-1s-1 | pH | Temp °C |
Platelet-derived growth factor receptor beta
(Homo sapiens (Human)) | BDBM445227
(US10669235, Example 18 | US11208381, Example 18)Show SMILES COC(=O)c1cc2NC(=O)\C(=C(/Nc3ccc(cc3)C(=O)NC3CCN(C)CC3)c3ccccc3)c2cc1C Show InChI InChI=1S/C31H32N4O4/c1-19-17-25-26(18-24(19)31(38)39-3)34-30(37)27(25)28(20-7-5-4-6-8-20)32-22-11-9-21(10-12-22)29(36)33-23-13-15-35(2)16-14-23/h4-12,17-18,23,32H,13-16H2,1-3H3,(H,33,36)(H,34,37)/b28-27- | PDB MMDB
NCI pathway Reactome pathway KEGG
UniProtKB/SwissProt
B.MOAD DrugBank antibodypedia GoogleScholar AffyNet
| PC cid PC sid UniChem
| US Patent
| 7.99 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
RESPIVERT LIMITED
US Patent
| Assay Description The inhibitory activities of compounds of the invention against PDGFRβ (PDGFRβ Kinase Enzyme System: Promega), were evaluated by mixing the... |
US Patent US10669235 (2020)
|
More data for this Ligand-Target Pair | |
VHL/PDGFRB
(Homo sapiens (Human)) | BDBM445227
(US10669235, Example 18 | US11208381, Example 18)Show SMILES COC(=O)c1cc2NC(=O)\C(=C(/Nc3ccc(cc3)C(=O)NC3CCN(C)CC3)c3ccccc3)c2cc1C Show InChI InChI=1S/C31H32N4O4/c1-19-17-25-26(18-24(19)31(38)39-3)34-30(37)27(25)28(20-7-5-4-6-8-20)32-22-11-9-21(10-12-22)29(36)33-23-13-15-35(2)16-14-23/h4-12,17-18,23,32H,13-16H2,1-3H3,(H,33,36)(H,34,37)/b28-27- | PDB MMDB
NCI pathway Reactome pathway KEGG
UniProtKB/SwissProt
B.MOAD DrugBank antibodypedia GoogleScholar AffyNet
| PC cid PC sid UniChem
| | 7.99 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
TBA
| |
Citation and Details
|
More data for this Ligand-Target Pair | |
Fibroblast growth factor receptor 3
(Homo sapiens (Human)) | BDBM445227
(US10669235, Example 18 | US11208381, Example 18)Show SMILES COC(=O)c1cc2NC(=O)\C(=C(/Nc3ccc(cc3)C(=O)NC3CCN(C)CC3)c3ccccc3)c2cc1C Show InChI InChI=1S/C31H32N4O4/c1-19-17-25-26(18-24(19)31(38)39-3)34-30(37)27(25)28(20-7-5-4-6-8-20)32-22-11-9-21(10-12-22)29(36)33-23-13-15-35(2)16-14-23/h4-12,17-18,23,32H,13-16H2,1-3H3,(H,33,36)(H,34,37)/b28-27- | PDB MMDB
Reactome pathway KEGG
UniProtKB/SwissProt
B.MOAD DrugBank antibodypedia GoogleScholar AffyNet
| PC cid PC sid UniChem
| | 13.7 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
TBA
| |
Citation and Details
|
More data for this Ligand-Target Pair | |
Fibroblast growth factor receptor 3
(Homo sapiens (Human)) | BDBM445227
(US10669235, Example 18 | US11208381, Example 18)Show SMILES COC(=O)c1cc2NC(=O)\C(=C(/Nc3ccc(cc3)C(=O)NC3CCN(C)CC3)c3ccccc3)c2cc1C Show InChI InChI=1S/C31H32N4O4/c1-19-17-25-26(18-24(19)31(38)39-3)34-30(37)27(25)28(20-7-5-4-6-8-20)32-22-11-9-21(10-12-22)29(36)33-23-13-15-35(2)16-14-23/h4-12,17-18,23,32H,13-16H2,1-3H3,(H,33,36)(H,34,37)/b28-27- | PDB MMDB
Reactome pathway KEGG
UniProtKB/SwissProt
B.MOAD DrugBank antibodypedia GoogleScholar AffyNet
| PC cid PC sid UniChem
| US Patent
| 13.7 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
RESPIVERT LIMITED
US Patent
| Assay Description The inhibitory activities of compounds of the invention against FGFR3 (FGFR3 Kinase Enzyme System: Promega), were evaluated by mixing the FGFR3 prote... |
US Patent US10669235 (2020)
|
More data for this Ligand-Target Pair | |
Platelet-derived growth factor receptor alpha
(Homo sapiens (Human)) | BDBM445227
(US10669235, Example 18 | US11208381, Example 18)Show SMILES COC(=O)c1cc2NC(=O)\C(=C(/Nc3ccc(cc3)C(=O)NC3CCN(C)CC3)c3ccccc3)c2cc1C Show InChI InChI=1S/C31H32N4O4/c1-19-17-25-26(18-24(19)31(38)39-3)34-30(37)27(25)28(20-7-5-4-6-8-20)32-22-11-9-21(10-12-22)29(36)33-23-13-15-35(2)16-14-23/h4-12,17-18,23,32H,13-16H2,1-3H3,(H,33,36)(H,34,37)/b28-27- | PDB
KEGG
UniProtKB/SwissProt
DrugBank antibodypedia GoogleScholar AffyNet
| PC cid PC sid UniChem
| US Patent
| 14.1 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
RESPIVERT LIMITED
US Patent
| Assay Description The inhibitory activities of compounds of the invention against PDGFRα (PDGFRα Kinase Enzyme System: Promega), were evaluated by mixing the... |
US Patent US10669235 (2020)
|
More data for this Ligand-Target Pair | |
Platelet-derived growth factor receptor alpha
(Homo sapiens (Human)) | BDBM445227
(US10669235, Example 18 | US11208381, Example 18)Show SMILES COC(=O)c1cc2NC(=O)\C(=C(/Nc3ccc(cc3)C(=O)NC3CCN(C)CC3)c3ccccc3)c2cc1C Show InChI InChI=1S/C31H32N4O4/c1-19-17-25-26(18-24(19)31(38)39-3)34-30(37)27(25)28(20-7-5-4-6-8-20)32-22-11-9-21(10-12-22)29(36)33-23-13-15-35(2)16-14-23/h4-12,17-18,23,32H,13-16H2,1-3H3,(H,33,36)(H,34,37)/b28-27- | PDB
KEGG
UniProtKB/SwissProt
DrugBank antibodypedia GoogleScholar AffyNet
| PC cid PC sid UniChem
| | 14.1 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
TBA
| |
Citation and Details
|
More data for this Ligand-Target Pair | |
Vascular endothelial growth factor receptor 2
(Homo sapiens (Human)) | BDBM445227
(US10669235, Example 18 | US11208381, Example 18)Show SMILES COC(=O)c1cc2NC(=O)\C(=C(/Nc3ccc(cc3)C(=O)NC3CCN(C)CC3)c3ccccc3)c2cc1C Show InChI InChI=1S/C31H32N4O4/c1-19-17-25-26(18-24(19)31(38)39-3)34-30(37)27(25)28(20-7-5-4-6-8-20)32-22-11-9-21(10-12-22)29(36)33-23-13-15-35(2)16-14-23/h4-12,17-18,23,32H,13-16H2,1-3H3,(H,33,36)(H,34,37)/b28-27- | PDB MMDB
NCI pathway Reactome pathway KEGG
UniProtKB/SwissProt
B.MOAD DrugBank antibodypedia GoogleScholar AffyNet
| PC cid PC sid UniChem
| | 25.7 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
TBA
| |
Citation and Details
|
More data for this Ligand-Target Pair | |
Vascular endothelial growth factor receptor 2
(Homo sapiens (Human)) | BDBM445227
(US10669235, Example 18 | US11208381, Example 18)Show SMILES COC(=O)c1cc2NC(=O)\C(=C(/Nc3ccc(cc3)C(=O)NC3CCN(C)CC3)c3ccccc3)c2cc1C Show InChI InChI=1S/C31H32N4O4/c1-19-17-25-26(18-24(19)31(38)39-3)34-30(37)27(25)28(20-7-5-4-6-8-20)32-22-11-9-21(10-12-22)29(36)33-23-13-15-35(2)16-14-23/h4-12,17-18,23,32H,13-16H2,1-3H3,(H,33,36)(H,34,37)/b28-27- | PDB MMDB
NCI pathway Reactome pathway KEGG
UniProtKB/SwissProt
B.MOAD DrugBank antibodypedia GoogleScholar AffyNet
| PC cid PC sid UniChem
| US Patent
| 25.7 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
RESPIVERT LIMITED
US Patent
| Assay Description The inhibitory activities of compounds of the invention against VEGFR2 (VEGFR2 Kinase Enzyme System: Promega), were evaluated by mixing the VEGFR2 pr... |
US Patent US10669235 (2020)
|
More data for this Ligand-Target Pair | |
Fibroblast growth factor receptor 1
(Homo sapiens (Human)) | BDBM445227
(US10669235, Example 18 | US11208381, Example 18)Show SMILES COC(=O)c1cc2NC(=O)\C(=C(/Nc3ccc(cc3)C(=O)NC3CCN(C)CC3)c3ccccc3)c2cc1C Show InChI InChI=1S/C31H32N4O4/c1-19-17-25-26(18-24(19)31(38)39-3)34-30(37)27(25)28(20-7-5-4-6-8-20)32-22-11-9-21(10-12-22)29(36)33-23-13-15-35(2)16-14-23/h4-12,17-18,23,32H,13-16H2,1-3H3,(H,33,36)(H,34,37)/b28-27- | PDB MMDB
NCI pathway Reactome pathway KEGG
UniProtKB/SwissProt
B.MOAD DrugBank antibodypedia GoogleScholar AffyNet
| PC cid PC sid UniChem
| US Patent
| 36.6 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
RESPIVERT LIMITED
US Patent
| Assay Description The inhibitory activities of compounds of the invention against FGFR1 (FGFR1 Kinase Enzyme System: Promega), were evaluated by mixing the FGFR1 prote... |
US Patent US10669235 (2020)
|
More data for this Ligand-Target Pair | |
Fibroblast growth factor receptor 1
(Homo sapiens (Human)) | BDBM445227
(US10669235, Example 18 | US11208381, Example 18)Show SMILES COC(=O)c1cc2NC(=O)\C(=C(/Nc3ccc(cc3)C(=O)NC3CCN(C)CC3)c3ccccc3)c2cc1C Show InChI InChI=1S/C31H32N4O4/c1-19-17-25-26(18-24(19)31(38)39-3)34-30(37)27(25)28(20-7-5-4-6-8-20)32-22-11-9-21(10-12-22)29(36)33-23-13-15-35(2)16-14-23/h4-12,17-18,23,32H,13-16H2,1-3H3,(H,33,36)(H,34,37)/b28-27- | PDB MMDB
NCI pathway Reactome pathway KEGG
UniProtKB/SwissProt
B.MOAD DrugBank antibodypedia GoogleScholar AffyNet
| PC cid PC sid UniChem
| | 36.6 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
TBA
| |
Citation and Details
|
More data for this Ligand-Target Pair | |
Vascular endothelial growth factor receptor 1
(Homo sapiens (Human)) | BDBM445227
(US10669235, Example 18 | US11208381, Example 18)Show SMILES COC(=O)c1cc2NC(=O)\C(=C(/Nc3ccc(cc3)C(=O)NC3CCN(C)CC3)c3ccccc3)c2cc1C Show InChI InChI=1S/C31H32N4O4/c1-19-17-25-26(18-24(19)31(38)39-3)34-30(37)27(25)28(20-7-5-4-6-8-20)32-22-11-9-21(10-12-22)29(36)33-23-13-15-35(2)16-14-23/h4-12,17-18,23,32H,13-16H2,1-3H3,(H,33,36)(H,34,37)/b28-27- | PDB MMDB
KEGG
UniProtKB/SwissProt UniProtKB/TrEMBL
B.MOAD DrugBank antibodypedia GoogleScholar AffyNet
| PC cid PC sid UniChem
| US Patent
| 57.5 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
RESPIVERT LIMITED
US Patent
| Assay Description The inhibitory activities of compounds of the invention against VEGFR1 (VEGFR1 Kinase Enzyme System: Promega), were evaluated by mixing the VEGFR1 pr... |
US Patent US10669235 (2020)
|
More data for this Ligand-Target Pair | |
Vascular endothelial growth factor receptor 1 and 2 (Flt-1 and KDR)
(Homo sapiens (Human)) | BDBM445227
(US10669235, Example 18 | US11208381, Example 18)Show SMILES COC(=O)c1cc2NC(=O)\C(=C(/Nc3ccc(cc3)C(=O)NC3CCN(C)CC3)c3ccccc3)c2cc1C Show InChI InChI=1S/C31H32N4O4/c1-19-17-25-26(18-24(19)31(38)39-3)34-30(37)27(25)28(20-7-5-4-6-8-20)32-22-11-9-21(10-12-22)29(36)33-23-13-15-35(2)16-14-23/h4-12,17-18,23,32H,13-16H2,1-3H3,(H,33,36)(H,34,37)/b28-27- | PDB MMDB
KEGG
UniProtKB/SwissProt UniProtKB/TrEMBL
B.MOAD DrugBank antibodypedia GoogleScholar AffyNet
| PC cid PC sid UniChem
| | 57.5 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
TBA
| |
Citation and Details
|
More data for this Ligand-Target Pair | |