Found 12 hits for monomerid = 445231 Target/Host (Institution) | Ligand | Target/Host Links | Ligand Links | Trg + Lig Links | Ki nM | ΔG° kcal/mole | IC50 nM | Kd nM | EC50/IC50 nM | koff s-1 | kon M-1s-1 | pH | Temp °C |
Platelet-derived growth factor receptor beta
(Homo sapiens (Human)) | BDBM445231
(US10669235, Example 22 | US11208381, Example 22)Show SMILES COC(=O)c1cc2NC(=O)\C(=C(/Nc3ccc(cc3)C(=O)NCCCN(C)C)c3ccccc3)c2cc1C Show InChI InChI=1S/C30H32N4O4/c1-19-17-24-25(18-23(19)30(37)38-4)33-29(36)26(24)27(20-9-6-5-7-10-20)32-22-13-11-21(12-14-22)28(35)31-15-8-16-34(2)3/h5-7,9-14,17-18,32H,8,15-16H2,1-4H3,(H,31,35)(H,33,36)/b27-26- | PDB MMDB
NCI pathway Reactome pathway KEGG
UniProtKB/SwissProt
B.MOAD DrugBank antibodypedia GoogleScholar AffyNet
| PC cid PC sid UniChem
| US Patent
| 9.29 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
RESPIVERT LIMITED
US Patent
| Assay Description The inhibitory activities of compounds of the invention against PDGFRβ (PDGFRβ Kinase Enzyme System: Promega), were evaluated by mixing the... |
US Patent US10669235 (2020)
|
More data for this Ligand-Target Pair | |
VHL/PDGFRB
(Homo sapiens (Human)) | BDBM445231
(US10669235, Example 22 | US11208381, Example 22)Show SMILES COC(=O)c1cc2NC(=O)\C(=C(/Nc3ccc(cc3)C(=O)NCCCN(C)C)c3ccccc3)c2cc1C Show InChI InChI=1S/C30H32N4O4/c1-19-17-24-25(18-23(19)30(37)38-4)33-29(36)26(24)27(20-9-6-5-7-10-20)32-22-13-11-21(12-14-22)28(35)31-15-8-16-34(2)3/h5-7,9-14,17-18,32H,8,15-16H2,1-4H3,(H,31,35)(H,33,36)/b27-26- | PDB MMDB
NCI pathway Reactome pathway KEGG
UniProtKB/SwissProt
B.MOAD DrugBank antibodypedia GoogleScholar AffyNet
| PC cid PC sid UniChem
| | 9.29 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
TBA
| |
Citation and Details
|
More data for this Ligand-Target Pair | |
Fibroblast growth factor receptor 3
(Homo sapiens (Human)) | BDBM445231
(US10669235, Example 22 | US11208381, Example 22)Show SMILES COC(=O)c1cc2NC(=O)\C(=C(/Nc3ccc(cc3)C(=O)NCCCN(C)C)c3ccccc3)c2cc1C Show InChI InChI=1S/C30H32N4O4/c1-19-17-24-25(18-23(19)30(37)38-4)33-29(36)26(24)27(20-9-6-5-7-10-20)32-22-13-11-21(12-14-22)28(35)31-15-8-16-34(2)3/h5-7,9-14,17-18,32H,8,15-16H2,1-4H3,(H,31,35)(H,33,36)/b27-26- | PDB MMDB
Reactome pathway KEGG
UniProtKB/SwissProt
B.MOAD DrugBank antibodypedia GoogleScholar AffyNet
| PC cid PC sid UniChem
| | 9.53 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
TBA
| |
Citation and Details
|
More data for this Ligand-Target Pair | |
Fibroblast growth factor receptor 3
(Homo sapiens (Human)) | BDBM445231
(US10669235, Example 22 | US11208381, Example 22)Show SMILES COC(=O)c1cc2NC(=O)\C(=C(/Nc3ccc(cc3)C(=O)NCCCN(C)C)c3ccccc3)c2cc1C Show InChI InChI=1S/C30H32N4O4/c1-19-17-24-25(18-23(19)30(37)38-4)33-29(36)26(24)27(20-9-6-5-7-10-20)32-22-13-11-21(12-14-22)28(35)31-15-8-16-34(2)3/h5-7,9-14,17-18,32H,8,15-16H2,1-4H3,(H,31,35)(H,33,36)/b27-26- | PDB MMDB
Reactome pathway KEGG
UniProtKB/SwissProt
B.MOAD DrugBank antibodypedia GoogleScholar AffyNet
| PC cid PC sid UniChem
| US Patent
| 9.53 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
RESPIVERT LIMITED
US Patent
| Assay Description The inhibitory activities of compounds of the invention against FGFR3 (FGFR3 Kinase Enzyme System: Promega), were evaluated by mixing the FGFR3 prote... |
US Patent US10669235 (2020)
|
More data for this Ligand-Target Pair | |
Platelet-derived growth factor receptor alpha
(Homo sapiens (Human)) | BDBM445231
(US10669235, Example 22 | US11208381, Example 22)Show SMILES COC(=O)c1cc2NC(=O)\C(=C(/Nc3ccc(cc3)C(=O)NCCCN(C)C)c3ccccc3)c2cc1C Show InChI InChI=1S/C30H32N4O4/c1-19-17-24-25(18-23(19)30(37)38-4)33-29(36)26(24)27(20-9-6-5-7-10-20)32-22-13-11-21(12-14-22)28(35)31-15-8-16-34(2)3/h5-7,9-14,17-18,32H,8,15-16H2,1-4H3,(H,31,35)(H,33,36)/b27-26- | PDB
KEGG
UniProtKB/SwissProt
DrugBank antibodypedia GoogleScholar AffyNet
| PC cid PC sid UniChem
| US Patent
| 9.75 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
RESPIVERT LIMITED
US Patent
| Assay Description The inhibitory activities of compounds of the invention against PDGFRα (PDGFRα Kinase Enzyme System: Promega), were evaluated by mixing the... |
US Patent US10669235 (2020)
|
More data for this Ligand-Target Pair | |
Platelet-derived growth factor receptor alpha
(Homo sapiens (Human)) | BDBM445231
(US10669235, Example 22 | US11208381, Example 22)Show SMILES COC(=O)c1cc2NC(=O)\C(=C(/Nc3ccc(cc3)C(=O)NCCCN(C)C)c3ccccc3)c2cc1C Show InChI InChI=1S/C30H32N4O4/c1-19-17-24-25(18-23(19)30(37)38-4)33-29(36)26(24)27(20-9-6-5-7-10-20)32-22-13-11-21(12-14-22)28(35)31-15-8-16-34(2)3/h5-7,9-14,17-18,32H,8,15-16H2,1-4H3,(H,31,35)(H,33,36)/b27-26- | PDB
KEGG
UniProtKB/SwissProt
DrugBank antibodypedia GoogleScholar AffyNet
| PC cid PC sid UniChem
| | 9.75 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
TBA
| |
Citation and Details
|
More data for this Ligand-Target Pair | |
Vascular endothelial growth factor receptor 2
(Homo sapiens (Human)) | BDBM445231
(US10669235, Example 22 | US11208381, Example 22)Show SMILES COC(=O)c1cc2NC(=O)\C(=C(/Nc3ccc(cc3)C(=O)NCCCN(C)C)c3ccccc3)c2cc1C Show InChI InChI=1S/C30H32N4O4/c1-19-17-24-25(18-23(19)30(37)38-4)33-29(36)26(24)27(20-9-6-5-7-10-20)32-22-13-11-21(12-14-22)28(35)31-15-8-16-34(2)3/h5-7,9-14,17-18,32H,8,15-16H2,1-4H3,(H,31,35)(H,33,36)/b27-26- | PDB MMDB
NCI pathway Reactome pathway KEGG
UniProtKB/SwissProt
B.MOAD DrugBank antibodypedia GoogleScholar AffyNet
| PC cid PC sid UniChem
| | 12.4 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
TBA
| |
Citation and Details
|
More data for this Ligand-Target Pair | |
Vascular endothelial growth factor receptor 2
(Homo sapiens (Human)) | BDBM445231
(US10669235, Example 22 | US11208381, Example 22)Show SMILES COC(=O)c1cc2NC(=O)\C(=C(/Nc3ccc(cc3)C(=O)NCCCN(C)C)c3ccccc3)c2cc1C Show InChI InChI=1S/C30H32N4O4/c1-19-17-24-25(18-23(19)30(37)38-4)33-29(36)26(24)27(20-9-6-5-7-10-20)32-22-13-11-21(12-14-22)28(35)31-15-8-16-34(2)3/h5-7,9-14,17-18,32H,8,15-16H2,1-4H3,(H,31,35)(H,33,36)/b27-26- | PDB MMDB
NCI pathway Reactome pathway KEGG
UniProtKB/SwissProt
B.MOAD DrugBank antibodypedia GoogleScholar AffyNet
| PC cid PC sid UniChem
| US Patent
| 12.4 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
RESPIVERT LIMITED
US Patent
| Assay Description The inhibitory activities of compounds of the invention against VEGFR2 (VEGFR2 Kinase Enzyme System: Promega), were evaluated by mixing the VEGFR2 pr... |
US Patent US10669235 (2020)
|
More data for this Ligand-Target Pair | |
Fibroblast growth factor receptor 1
(Homo sapiens (Human)) | BDBM445231
(US10669235, Example 22 | US11208381, Example 22)Show SMILES COC(=O)c1cc2NC(=O)\C(=C(/Nc3ccc(cc3)C(=O)NCCCN(C)C)c3ccccc3)c2cc1C Show InChI InChI=1S/C30H32N4O4/c1-19-17-24-25(18-23(19)30(37)38-4)33-29(36)26(24)27(20-9-6-5-7-10-20)32-22-13-11-21(12-14-22)28(35)31-15-8-16-34(2)3/h5-7,9-14,17-18,32H,8,15-16H2,1-4H3,(H,31,35)(H,33,36)/b27-26- | PDB MMDB
NCI pathway Reactome pathway KEGG
UniProtKB/SwissProt
B.MOAD DrugBank antibodypedia GoogleScholar AffyNet
| PC cid PC sid UniChem
| US Patent
| 16.3 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
RESPIVERT LIMITED
US Patent
| Assay Description The inhibitory activities of compounds of the invention against FGFR1 (FGFR1 Kinase Enzyme System: Promega), were evaluated by mixing the FGFR1 prote... |
US Patent US10669235 (2020)
|
More data for this Ligand-Target Pair | |
Fibroblast growth factor receptor 1
(Homo sapiens (Human)) | BDBM445231
(US10669235, Example 22 | US11208381, Example 22)Show SMILES COC(=O)c1cc2NC(=O)\C(=C(/Nc3ccc(cc3)C(=O)NCCCN(C)C)c3ccccc3)c2cc1C Show InChI InChI=1S/C30H32N4O4/c1-19-17-24-25(18-23(19)30(37)38-4)33-29(36)26(24)27(20-9-6-5-7-10-20)32-22-13-11-21(12-14-22)28(35)31-15-8-16-34(2)3/h5-7,9-14,17-18,32H,8,15-16H2,1-4H3,(H,31,35)(H,33,36)/b27-26- | PDB MMDB
NCI pathway Reactome pathway KEGG
UniProtKB/SwissProt
B.MOAD DrugBank antibodypedia GoogleScholar AffyNet
| PC cid PC sid UniChem
| | 16.3 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
TBA
| |
Citation and Details
|
More data for this Ligand-Target Pair | |
Vascular endothelial growth factor receptor 1
(Homo sapiens (Human)) | BDBM445231
(US10669235, Example 22 | US11208381, Example 22)Show SMILES COC(=O)c1cc2NC(=O)\C(=C(/Nc3ccc(cc3)C(=O)NCCCN(C)C)c3ccccc3)c2cc1C Show InChI InChI=1S/C30H32N4O4/c1-19-17-24-25(18-23(19)30(37)38-4)33-29(36)26(24)27(20-9-6-5-7-10-20)32-22-13-11-21(12-14-22)28(35)31-15-8-16-34(2)3/h5-7,9-14,17-18,32H,8,15-16H2,1-4H3,(H,31,35)(H,33,36)/b27-26- | PDB MMDB
KEGG
UniProtKB/SwissProt UniProtKB/TrEMBL
B.MOAD DrugBank antibodypedia GoogleScholar AffyNet
| PC cid PC sid UniChem
| US Patent
| 63.2 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
RESPIVERT LIMITED
US Patent
| Assay Description The inhibitory activities of compounds of the invention against VEGFR1 (VEGFR1 Kinase Enzyme System: Promega), were evaluated by mixing the VEGFR1 pr... |
US Patent US10669235 (2020)
|
More data for this Ligand-Target Pair | |
Vascular endothelial growth factor receptor 1 and 2 (Flt-1 and KDR)
(Homo sapiens (Human)) | BDBM445231
(US10669235, Example 22 | US11208381, Example 22)Show SMILES COC(=O)c1cc2NC(=O)\C(=C(/Nc3ccc(cc3)C(=O)NCCCN(C)C)c3ccccc3)c2cc1C Show InChI InChI=1S/C30H32N4O4/c1-19-17-24-25(18-23(19)30(37)38-4)33-29(36)26(24)27(20-9-6-5-7-10-20)32-22-13-11-21(12-14-22)28(35)31-15-8-16-34(2)3/h5-7,9-14,17-18,32H,8,15-16H2,1-4H3,(H,31,35)(H,33,36)/b27-26- | PDB MMDB
KEGG
UniProtKB/SwissProt UniProtKB/TrEMBL
B.MOAD DrugBank antibodypedia GoogleScholar AffyNet
| PC cid PC sid UniChem
| | 63.2 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
TBA
| |
Citation and Details
|
More data for this Ligand-Target Pair | |