BDBM445250 US10669235, Example 41

SMILES: COC(=O)c1cc2NC(=O)\C(=C(/Nc3ccc(cc3)C(=O)N(C)C3CCN(CCO)CC3)c3ccccc3)c2cc1C

InChI Key: InChIKey=PGQJZWZFOOWFNP-FLWNBWAVSA-N

Data: 6 KI

Find this compound or compounds like it in BindingDB or PDB:

Substructure Similarity at least:  must be >=0.5 Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 6 hits for monomerid = 445250   

Target/Host (Institution)	Ligand	Target/Host Links	Ligand Links	Trg + Lig Links	Ki nM	ΔG° kcal/mole	IC50 nM	Kd nM	EC50/IC50 nM	koff s-1	kon M-1s-1	pH	Temp °C
Fibroblast growth factor receptor 3 (Homo sapiens (Human))	BDBM445250 (US10669235, Example 41) Show SMILES COC(=O)c1cc2NC(=O)\C(=C(/Nc3ccc(cc3)C(=O)N(C)C3CCN(CCO)CC3)c3ccccc3)c2cc1C Show InChI InChI=1S/C33H36N4O5/c1-21-19-27-28(20-26(21)33(41)42-3)35-31(39)29(27)30(22-7-5-4-6-8-22)34-24-11-9-23(10-12-24)32(40)36(2)25-13-15-37(16-14-25)17-18-38/h4-12,19-20,25,34,38H,13-18H2,1-3H3,(H,35,39)/b30-29-	PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	9.31	n/a	n/a	n/a	n/a	n/a	n/a	n/a	n/a
RESPIVERT LIMITED US Patent					Assay Description The inhibitory activities of compounds of the invention against FGFR3 (FGFR3 Kinase Enzyme System: Promega), were evaluated by mixing the FGFR3 prote...				US Patent US10669235 (2020)
					More data for this Ligand-Target Pair
Platelet-derived growth factor receptor beta (Homo sapiens (Human))	BDBM445250 (US10669235, Example 41) Show SMILES COC(=O)c1cc2NC(=O)\C(=C(/Nc3ccc(cc3)C(=O)N(C)C3CCN(CCO)CC3)c3ccccc3)c2cc1C Show InChI InChI=1S/C33H36N4O5/c1-21-19-27-28(20-26(21)33(41)42-3)35-31(39)29(27)30(22-7-5-4-6-8-22)34-24-11-9-23(10-12-24)32(40)36(2)25-13-15-37(16-14-25)17-18-38/h4-12,19-20,25,34,38H,13-18H2,1-3H3,(H,35,39)/b30-29-	PDB MMDB NCI pathway Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	10.2	n/a	n/a	n/a	n/a	n/a	n/a	n/a	n/a
RESPIVERT LIMITED US Patent					Assay Description The inhibitory activities of compounds of the invention against PDGFRβ (PDGFRβ Kinase Enzyme System: Promega), were evaluated by mixing the...				US Patent US10669235 (2020)
					More data for this Ligand-Target Pair
Platelet-derived growth factor receptor alpha (Homo sapiens (Human))	BDBM445250 (US10669235, Example 41) Show SMILES COC(=O)c1cc2NC(=O)\C(=C(/Nc3ccc(cc3)C(=O)N(C)C3CCN(CCO)CC3)c3ccccc3)c2cc1C Show InChI InChI=1S/C33H36N4O5/c1-21-19-27-28(20-26(21)33(41)42-3)35-31(39)29(27)30(22-7-5-4-6-8-22)34-24-11-9-23(10-12-24)32(40)36(2)25-13-15-37(16-14-25)17-18-38/h4-12,19-20,25,34,38H,13-18H2,1-3H3,(H,35,39)/b30-29-	PDB KEGG UniProtKB/SwissProt DrugBank antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	13.8	n/a	n/a	n/a	n/a	n/a	n/a	n/a	n/a
RESPIVERT LIMITED US Patent					Assay Description The inhibitory activities of compounds of the invention against PDGFRα (PDGFRα Kinase Enzyme System: Promega), were evaluated by mixing the...				US Patent US10669235 (2020)
					More data for this Ligand-Target Pair
Vascular endothelial growth factor receptor 2 (Homo sapiens (Human))	BDBM445250 (US10669235, Example 41) Show SMILES COC(=O)c1cc2NC(=O)\C(=C(/Nc3ccc(cc3)C(=O)N(C)C3CCN(CCO)CC3)c3ccccc3)c2cc1C Show InChI InChI=1S/C33H36N4O5/c1-21-19-27-28(20-26(21)33(41)42-3)35-31(39)29(27)30(22-7-5-4-6-8-22)34-24-11-9-23(10-12-24)32(40)36(2)25-13-15-37(16-14-25)17-18-38/h4-12,19-20,25,34,38H,13-18H2,1-3H3,(H,35,39)/b30-29-	PDB MMDB NCI pathway Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	17.7	n/a	n/a	n/a	n/a	n/a	n/a	n/a	n/a
RESPIVERT LIMITED US Patent					Assay Description The inhibitory activities of compounds of the invention against VEGFR2 (VEGFR2 Kinase Enzyme System: Promega), were evaluated by mixing the VEGFR2 pr...				US Patent US10669235 (2020)
					More data for this Ligand-Target Pair
Fibroblast growth factor receptor 1 (Homo sapiens (Human))	BDBM445250 (US10669235, Example 41) Show SMILES COC(=O)c1cc2NC(=O)\C(=C(/Nc3ccc(cc3)C(=O)N(C)C3CCN(CCO)CC3)c3ccccc3)c2cc1C Show InChI InChI=1S/C33H36N4O5/c1-21-19-27-28(20-26(21)33(41)42-3)35-31(39)29(27)30(22-7-5-4-6-8-22)34-24-11-9-23(10-12-24)32(40)36(2)25-13-15-37(16-14-25)17-18-38/h4-12,19-20,25,34,38H,13-18H2,1-3H3,(H,35,39)/b30-29-	PDB MMDB NCI pathway Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	23.8	n/a	n/a	n/a	n/a	n/a	n/a	n/a	n/a
RESPIVERT LIMITED US Patent					Assay Description The inhibitory activities of compounds of the invention against FGFR1 (FGFR1 Kinase Enzyme System: Promega), were evaluated by mixing the FGFR1 prote...				US Patent US10669235 (2020)
					More data for this Ligand-Target Pair
Vascular endothelial growth factor receptor 1 (Homo sapiens (Human))	BDBM445250 (US10669235, Example 41) Show SMILES COC(=O)c1cc2NC(=O)\C(=C(/Nc3ccc(cc3)C(=O)N(C)C3CCN(CCO)CC3)c3ccccc3)c2cc1C Show InChI InChI=1S/C33H36N4O5/c1-21-19-27-28(20-26(21)33(41)42-3)35-31(39)29(27)30(22-7-5-4-6-8-22)34-24-11-9-23(10-12-24)32(40)36(2)25-13-15-37(16-14-25)17-18-38/h4-12,19-20,25,34,38H,13-18H2,1-3H3,(H,35,39)/b30-29-	PDB MMDB KEGG UniProtKB/SwissProt UniProtKB/TrEMBL B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	49.7	n/a	n/a	n/a	n/a	n/a	n/a	n/a	n/a
RESPIVERT LIMITED US Patent					Assay Description The inhibitory activities of compounds of the invention against VEGFR1 (VEGFR1 Kinase Enzyme System: Promega), were evaluated by mixing the VEGFR1 pr...				US Patent US10669235 (2020)
					More data for this Ligand-Target Pair