null

SMILES: Cc1c(Nc2nc(nc3cc(CN4CC[C@@H](O)C4)cnc23)C(F)F)cccc1-c1cccc(-c2nc3cc(CN4CCC(C)(CC4)C(O)=O)cc(C#N)c3o2)c1C

InChI Key: InChIKey=FMVZPQSIRWVHLC-GDLZYMKVSA-N

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 3 hits for monomerid = 446471   

Target/Host (Institution)	Ligand	Target/Host Links	Ligand Links	Trg + Lig Links	Ki nM	ΔG° kcal/mole	IC50 nM	Kd nM	EC50/IC50 nM	koff s-1	kon M-1s-1	pH	Temp °C
Programmed cell death 1 ligand 1 [19-238]/protein 1 [25-167] (Homo sapiens (Human))	BDBM446471 ((R)-1-((7-cyano-2-(3′-(2-(difluoromethyl)-7-...) Show SMILES Cc1c(Nc2nc(nc3cc(CN4CC[C@@H](O)C4)cnc23)C(F)F)cccc1-c1cccc(-c2nc3cc(CN4CCC(C)(CC4)C(O)=O)cc(C#N)c3o2)c1C |r| Show InChI InChI=1S/C43H42F2N8O4/c1-24-30(6-4-8-32(24)41-50-35-17-26(16-28(19-46)37(35)57-41)21-52-14-11-43(3,12-15-52)42(55)56)31-7-5-9-33(25(31)2)48-39-36-34(49-40(51-39)38(44)45)18-27(20-47-36)22-53-13-10-29(54)23-53/h4-9,16-18,20,29,38,54H,10-15,21-23H2,1-3H3,(H,55,56)(H,48,49,51)/t29-/m1/s1	PDB MMDB NCI pathway Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	<10	n/a	n/a	n/a	n/a	n/a	n/a
Incyte Corporation US Patent					Assay Description The assays were conducted in a standard black 384-well polystyrene plate with a final volume of 20 μL. Inhibitors were first serially diluted in...				US Patent US10669271 (2020)
					More data for this Ligand-Target Pair
Programmed cell death 1 ligand 1 [19-238]/protein 1 [25-167] (Homo sapiens (Human))	BDBM446471 ((R)-1-((7-cyano-2-(3′-(2-(difluoromethyl)-7-...) Show SMILES Cc1c(Nc2nc(nc3cc(CN4CC[C@@H](O)C4)cnc23)C(F)F)cccc1-c1cccc(-c2nc3cc(CN4CCC(C)(CC4)C(O)=O)cc(C#N)c3o2)c1C |r| Show InChI InChI=1S/C43H42F2N8O4/c1-24-30(6-4-8-32(24)41-50-35-17-26(16-28(19-46)37(35)57-41)21-52-14-11-43(3,12-15-52)42(55)56)31-7-5-9-33(25(31)2)48-39-36-34(49-40(51-39)38(44)45)18-27(20-47-36)22-53-13-10-29(54)23-53/h4-9,16-18,20,29,38,54H,10-15,21-23H2,1-3H3,(H,55,56)(H,48,49,51)/t29-/m1/s1	PDB MMDB NCI pathway Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank GoogleScholar AffyNet	PC cid PC sid UniChem		n/a	n/a	<10	n/a	n/a	n/a	n/a	n/a	n/a
TBA									Citation and Details
					More data for this Ligand-Target Pair
Nuclear factor NF-kappa-B p105 subunit (Homo sapiens (Human))	BDBM446471 ((R)-1-((7-cyano-2-(3′-(2-(difluoromethyl)-7-...) Show SMILES Cc1c(Nc2nc(nc3cc(CN4CC[C@@H](O)C4)cnc23)C(F)F)cccc1-c1cccc(-c2nc3cc(CN4CCC(C)(CC4)C(O)=O)cc(C#N)c3o2)c1C |r| Show InChI InChI=1S/C43H42F2N8O4/c1-24-30(6-4-8-32(24)41-50-35-17-26(16-28(19-46)37(35)57-41)21-52-14-11-43(3,12-15-52)42(55)56)31-7-5-9-33(25(31)2)48-39-36-34(49-40(51-39)38(44)45)18-27(20-47-36)22-53-13-10-29(54)23-53/h4-9,16-18,20,29,38,54H,10-15,21-23H2,1-3H3,(H,55,56)(H,48,49,51)/t29-/m1/s1	PDB UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	n/a	n/a	55	n/a	n/a	n/a	n/a
Incyte Corporation US Patent					Assay Description PD-L1 aAPC/CHO-Klcells (Promega) were maintained in F-12 medium with addition of 10% FBS, 200 μg/ml Hygromycin B, 250 μg/ml Geneticin (G418...				US Patent US10669271 (2020)
					More data for this Ligand-Target Pair