null
SMILES: CNC(=O)C1CCN(Cc2cc(C#N)c3oc(nc3c2)-c2cccc(c2C)-c2cccc(Nc3nc(nc4cc(CN5CC[C@@H](O)C5)cnc34)C(F)F)c2C)CC1
InChI Key: InChIKey=JWXSUZXXIIEXGM-SSEXGKCCSA-N
Target/Host (Institution) | Ligand | Target/Host Links | Ligand Links | Trg + Lig Links | Ki nM | ΔG° kcal/mole | IC50 nM | Kd nM | EC50/IC50 nM | koff s-1 | kon M-1s-1 | pH | Temp °C |
---|---|---|---|---|---|---|---|---|---|---|---|---|---|
Programmed cell death 1 ligand 1 [19-238]/protein 1 [25-167] (Homo sapiens (Human)) | BDBM446473 ((R)-1-((7-cyano-2-(3′-(2-(difluoromethyl)-7-...) | PDB MMDB NCI pathway Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank GoogleScholar AffyNet | PC cid PC sid UniChem | US Patent | n/a | n/a | <10 | n/a | n/a | n/a | n/a | n/a | n/a |
Incyte Corporation US Patent | Assay Description The assays were conducted in a standard black 384-well polystyrene plate with a final volume of 20 μL. Inhibitors were first serially diluted in... | US Patent US10669271 (2020) | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Programmed cell death 1 ligand 1 [19-238]/protein 1 [25-167] (Homo sapiens (Human)) | BDBM446473 ((R)-1-((7-cyano-2-(3′-(2-(difluoromethyl)-7-...) | PDB MMDB NCI pathway Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank GoogleScholar AffyNet | PC cid PC sid UniChem | n/a | n/a | <10 | n/a | n/a | n/a | n/a | n/a | n/a | |
TBA | Citation and Details | ||||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Nuclear factor NF-kappa-B p105 subunit (Homo sapiens (Human)) | BDBM446473 ((R)-1-((7-cyano-2-(3′-(2-(difluoromethyl)-7-...) | PDB UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet | PC cid PC sid UniChem | US Patent | n/a | n/a | n/a | n/a | <10 | n/a | n/a | n/a | n/a |
Incyte Corporation US Patent | Assay Description PD-L1 aAPC/CHO-Klcells (Promega) were maintained in F-12 medium with addition of 10% FBS, 200 μg/ml Hygromycin B, 250 μg/ml Geneticin (G418... | US Patent US10669271 (2020) | |||||||||||
More data for this Ligand-Target Pair |