null

SMILES: Cc1c(Nc2nc(cc3cc(CN4CC[C@@H](O)C4)cnc23)C(F)F)cccc1-c1cccc(-c2nc3cc(CN4CC[C@](C)(C4)C(O)=O)cc(C#N)c3o2)c1C

InChI Key: InChIKey=LLCKWXCPDAUVGI-QHKNHCAJSA-N

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 3 hits for monomerid = 446481   

Target/Host (Institution)	Ligand	Target/Host Links	Ligand Links	Trg + Lig Links	Ki nM	ΔG° kcal/mole	IC50 nM	Kd nM	EC50/IC50 nM	koff s-1	kon M-1s-1	pH	Temp °C
Programmed cell death 1 ligand 1 [19-238]/protein 1 [25-167] (Homo sapiens (Human))	BDBM446481 ((R)-1-((7-cyano-2-(3′-(6-(difluoromethyl)-3-...) Show SMILES Cc1c(Nc2nc(cc3cc(CN4CC[C@@H](O)C4)cnc23)C(F)F)cccc1-c1cccc(-c2nc3cc(CN4CC[C@](C)(C4)C(O)=O)cc(C#N)c3o2)c1C |r| Show InChI InChI=1S/C43H41F2N7O4/c1-24-31(6-4-8-33(24)41-50-35-16-26(14-29(18-46)38(35)56-41)20-52-13-11-43(3,23-52)42(54)55)32-7-5-9-34(25(32)2)48-40-37-28(17-36(49-40)39(44)45)15-27(19-47-37)21-51-12-10-30(53)22-51/h4-9,14-17,19,30,39,53H,10-13,20-23H2,1-3H3,(H,48,49)(H,54,55)/t30-,43-/m1/s1	PDB MMDB NCI pathway Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	<10	n/a	n/a	n/a	n/a	n/a	n/a
Incyte Corporation US Patent					Assay Description The assays were conducted in a standard black 384-well polystyrene plate with a final volume of 20 μL. Inhibitors were first serially diluted in...				US Patent US10669271 (2020)
					More data for this Ligand-Target Pair
Programmed cell death 1 ligand 1 [19-238]/protein 1 [25-167] (Homo sapiens (Human))	BDBM446481 ((R)-1-((7-cyano-2-(3′-(6-(difluoromethyl)-3-...) Show SMILES Cc1c(Nc2nc(cc3cc(CN4CC[C@@H](O)C4)cnc23)C(F)F)cccc1-c1cccc(-c2nc3cc(CN4CC[C@](C)(C4)C(O)=O)cc(C#N)c3o2)c1C |r| Show InChI InChI=1S/C43H41F2N7O4/c1-24-31(6-4-8-33(24)41-50-35-16-26(14-29(18-46)38(35)56-41)20-52-13-11-43(3,23-52)42(54)55)32-7-5-9-34(25(32)2)48-40-37-28(17-36(49-40)39(44)45)15-27(19-47-37)21-51-12-10-30(53)22-51/h4-9,14-17,19,30,39,53H,10-13,20-23H2,1-3H3,(H,48,49)(H,54,55)/t30-,43-/m1/s1	PDB MMDB NCI pathway Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank GoogleScholar AffyNet	PC cid PC sid UniChem		n/a	n/a	<10	n/a	n/a	n/a	n/a	n/a	n/a
TBA									Citation and Details
					More data for this Ligand-Target Pair
Nuclear factor NF-kappa-B p105 subunit (Homo sapiens (Human))	BDBM446481 ((R)-1-((7-cyano-2-(3′-(6-(difluoromethyl)-3-...) Show SMILES Cc1c(Nc2nc(cc3cc(CN4CC[C@@H](O)C4)cnc23)C(F)F)cccc1-c1cccc(-c2nc3cc(CN4CC[C@](C)(C4)C(O)=O)cc(C#N)c3o2)c1C |r| Show InChI InChI=1S/C43H41F2N7O4/c1-24-31(6-4-8-33(24)41-50-35-16-26(14-29(18-46)38(35)56-41)20-52-13-11-43(3,23-52)42(54)55)32-7-5-9-34(25(32)2)48-40-37-28(17-36(49-40)39(44)45)15-27(19-47-37)21-51-12-10-30(53)22-51/h4-9,14-17,19,30,39,53H,10-13,20-23H2,1-3H3,(H,48,49)(H,54,55)/t30-,43-/m1/s1	PDB UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	n/a	n/a	<10	n/a	n/a	n/a	n/a
Incyte Corporation US Patent					Assay Description PD-L1 aAPC/CHO-Klcells (Promega) were maintained in F-12 medium with addition of 10% FBS, 200 μg/ml Hygromycin B, 250 μg/ml Geneticin (G418...				US Patent US10669271 (2020)
					More data for this Ligand-Target Pair