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SMILES: CNc1nc(Nc2ccc(c(F)c2)-n2cnc(C)c2)nc2N(CCC(C)(C)c12)c1ccc(F)cc1

InChI Key: InChIKey=NRWGIDOUWVIXDV-UHFFFAOYSA-N

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Similarity at least:  must be >=0.5
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 1 hit for monomerid = 446547   
Target/Host
(Institution)		LigandTarget/Host
Links		Ligand
Links		Trg + Lig
Links		Ki
nM		ΔG°
kcal/mole		IC50
nM		Kd
nM		EC50/IC50
nM		koff
s-1		kon
M-1s-1		pHTemp
°C
Amyloid-beta precursor protein [672-713]


(Homo sapiens (Human))		BDBM446547
PNG
(N2-(3-Fluoro-4-(4-methyl-1H-imidazol-1-yl)phenyl)-...)
Show SMILES CNc1nc(Nc2ccc(c(F)c2)-n2cnc(C)c2)nc2N(CCC(C)(C)c12)c1ccc(F)cc1
Show InChI InChI=1S/C26H27F2N7/c1-16-14-34(15-30-16)21-10-7-18(13-20(21)28)31-25-32-23(29-4)22-24(33-25)35(12-11-26(22,2)3)19-8-5-17(27)6-9-19/h5-10,13-15H,11-12H2,1-4H3,(H2,29,31,32,33)
UniProtKB/SwissProt

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PC cid
PC sid
UniChem
US Patent
n/an/an/an/a 8n/an/an/an/a



HOFFMANN-LA ROCHE INC.

US Patent


Assay Description
Human neuroglioma H4 cells overexpressing human APP695 with the Swedish double mutation (K595N/M596L) were plated at 30,000 cells/well/100 μl in...

US Patent US10669276 (2020)


BindingDB Entry DOI: 10.7270/Q2BZ6928
More data for this
Ligand-Target Pair