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SMILES: Cc1cn(cn1)-c1ccc(Nc2nc3N(CCc3c(Cl)n2)c2ccc(F)cc2)cc1F

InChI Key: InChIKey=HXYNPUPINMSUIJ-UHFFFAOYSA-N

Find this compound or compounds like it in BindingDB or PDB:
   Substructure
Similarity at least:  must be >=0.5
Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 1 hit for monomerid = 446548   
Target/Host
(Institution)		LigandTarget/Host
Links		Ligand
Links		Trg + Lig
Links		Ki
nM		ΔG°
kcal/mole		IC50
nM		Kd
nM		EC50/IC50
nM		koff
s-1		kon
M-1s-1		pHTemp
°C
Amyloid-beta precursor protein [672-713]


(Homo sapiens (Human))		BDBM446548
PNG
(N2-(3-Fluoro-4-(4-methyl-1H-imidazol-1-yl)phenyl)-...)
Show SMILES Cc1cn(cn1)-c1ccc(Nc2nc3N(CCc3c(Cl)n2)c2ccc(F)cc2)cc1F
Show InChI InChI=1S/C22H17ClF2N6/c1-13-11-30(12-26-13)19-7-4-15(10-18(19)25)27-22-28-20(23)17-8-9-31(21(17)29-22)16-5-2-14(24)3-6-16/h2-7,10-12H,8-9H2,1H3,(H,27,28,29)
UniProtKB/SwissProt

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PC cid
PC sid
UniChem
US Patent
n/an/an/an/a 6n/an/an/an/a



HOFFMANN-LA ROCHE INC.

US Patent


Assay Description
Human neuroglioma H4 cells overexpressing human APP695 with the Swedish double mutation (K595N/M596L) were plated at 30,000 cells/well/100 μl in...

US Patent US10669276 (2020)


BindingDB Entry DOI: 10.7270/Q2BZ6928
More data for this
Ligand-Target Pair