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SMILES: COc1cc(Nc2nc3N(CC(C)c3c(Cl)n2)c2ccc(F)cc2)ccc1-n1cnc(C)n1

InChI Key: InChIKey=PWUVQLDJGGITJA-UHFFFAOYSA-N

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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 1 hit for monomerid = 446549   
Target/Host
(Institution)		LigandTarget/Host
Links		Ligand
Links		Trg + Lig
Links		Ki
nM		ΔG°
kcal/mole		IC50
nM		Kd
nM		EC50/IC50
nM		koff
s-1		kon
M-1s-1		pHTemp
°C
Amyloid-beta precursor protein [672-713]


(Homo sapiens (Human))		BDBM446549
PNG
(7-(4-Fluorophenyl)-N2-(3-methoxy-4-(3-methyl-1H-1,...)
Show SMILES COc1cc(Nc2nc3N(CC(C)c3c(Cl)n2)c2ccc(F)cc2)ccc1-n1cnc(C)n1
Show InChI InChI=1S/C23H21ClFN7O/c1-13-11-31(17-7-4-15(25)5-8-17)22-20(13)21(24)28-23(29-22)27-16-6-9-18(19(10-16)33-3)32-12-26-14(2)30-32/h4-10,12-13H,11H2,1-3H3,(H,27,28,29)
UniProtKB/SwissProt

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PC cid
PC sid
UniChem
US Patent
n/an/an/an/a 6n/an/an/an/a



HOFFMANN-LA ROCHE INC.

US Patent


Assay Description
Human neuroglioma H4 cells overexpressing human APP695 with the Swedish double mutation (K595N/M596L) were plated at 30,000 cells/well/100 μl in...

US Patent US10669276 (2020)


BindingDB Entry DOI: 10.7270/Q2BZ6928
More data for this
Ligand-Target Pair