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SMILES: C[C@@H](NC(=O)c1cn2CC3O[C@@H]4CC[C@H](C4)N3C(=O)c2c(O)c1=O)c1ccc(F)cc1F

InChI Key: InChIKey=HZQGBUQIMZZLDE-VGWNDNRCSA-N

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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 1 hit for monomerid = 448198   
Target/Host
(Institution)		LigandTarget/Host
Links		Ligand
Links		Trg + Lig
Links		Ki
nM		ΔG°
kcal/mole		IC50
nM		Kd
nM		EC50/IC50
nM		koff
s-1		kon
M-1s-1		pHTemp
°C
POU domain, class 2, transcription factor 2


(Homo sapiens (Human))		BDBM448198
PNG
(US10689399, Compound 13)
Show SMILES C[C@@H](NC(=O)c1cn2CC3O[C@@H]4CC[C@H](C4)N3C(=O)c2c(O)c1=O)c1ccc(F)cc1F |THB:8:9:12.13:15,17:16:12.13:15|
Show InChI InChI=1S/C22H21F2N3O5/c1-10(14-5-2-11(23)6-16(14)24)25-21(30)15-8-26-9-17-27(12-3-4-13(7-12)32-17)22(31)18(26)20(29)19(15)28/h2,5-6,8,10,12-13,17,29H,3-4,7,9H2,1H3,(H,25,30)/t10-,12-,13-,17?/m1/s1
PDB

UniProtKB/SwissProt

GoogleScholar
AffyNet 
PC cid
PC sid
UniChem
US Patent
n/an/a 610n/an/an/an/an/an/a



Gilead Sciences, Inc.

US Patent


Assay Description
The dose dependent inhibition of OCT2 mediated uptake of a model substrate 14C-Tetraethylammonium (TEA) by test compounds was studied in wild-type an...

US Patent US10689399 (2020)

More data for this
Ligand-Target Pair