Found 14 hits for monomerid = 451778 Target/Host
(Institution) | Ligand | Target/Host
Links | Ligand
Links | Trg + Lig
Links | Ki
nM | ΔG°
kcal/mole | IC50
nM | Kd
nM | EC50/IC50
nM | koff
s-1 | kon
M-1s-1 | pH | Temp
°C |
|---|
Activin receptor type-1 [172-499]
(Homo sapiens (Human)) | BDBM451778
(US10710980, Example 10 | US10947218, Example 10)Show SMILES Nc1ncc(cc1C(=O)N[C@H]1CC[C@H](O)CC1)-c1ccc(cc1)[C@@]12C[C@@H]1CN(CCN1CCOCC1)C2 |r,wU:23.25,10.10,wD:25.27,13.14,(-5.42,6.3,;-4.09,5.53,;-2.75,6.3,;-1.42,5.53,;-1.42,3.99,;-2.75,3.22,;-4.09,3.99,;-5.42,3.22,;-6.76,3.99,;-5.42,1.68,;-6.76,.91,;-6.89,-.63,;-8.29,-1.28,;-9.55,-.39,;-10.75,-1.04,;-9.41,1.14,;-8.02,1.79,;-.09,3.22,;-.09,1.68,;1.25,.91,;2.58,1.68,;2.58,3.22,;1.25,3.99,;3.91,.91,;4.07,2.44,;5.32,1.53,;6.35,.39,;5.58,-.94,;6.21,-2.35,;7.74,-2.34,;8.44,-3.63,;7.67,-4.96,;8.44,-6.3,;9.98,-6.3,;10.75,-4.96,;9.98,-3.63,;4.07,-.62,)| Show InChI InChI=1S/C29H39N5O3/c30-27-26(28(36)32-24-5-7-25(35)8-6-24)15-21(17-31-27)20-1-3-22(4-2-20)29-16-23(29)18-34(19-29)10-9-33-11-13-37-14-12-33/h1-4,15,17,23-25,35H,5-14,16,18-19H2,(H2,30,31)(H,32,36)/t23-,24-,25-,29+/m1/s1 | PDB
UniProtKB/SwissProt
GoogleScholar
AffyNet 
| PC cid
PC sid
UniChem
| US Patent
| n/a | n/a | 11 | n/a | n/a | n/a | n/a | n/a | n/a |
Novartis AG
US Patent
| Assay Description
The assays were performed in 384-well, low volume microtiter assay plates in a final reaction volume of 6 ul. Dose-response curves were generated by ... |
US Patent US10710980 (2020)
|
More data for this
Ligand-Target Pair | |
Bone morphogenetic protein receptor type-1A [198-525]
(Homo sapiens (Human)) | BDBM451778
(US10710980, Example 10 | US10947218, Example 10)Show SMILES Nc1ncc(cc1C(=O)N[C@H]1CC[C@H](O)CC1)-c1ccc(cc1)[C@@]12C[C@@H]1CN(CCN1CCOCC1)C2 |r,wU:23.25,10.10,wD:25.27,13.14,(-5.42,6.3,;-4.09,5.53,;-2.75,6.3,;-1.42,5.53,;-1.42,3.99,;-2.75,3.22,;-4.09,3.99,;-5.42,3.22,;-6.76,3.99,;-5.42,1.68,;-6.76,.91,;-6.89,-.63,;-8.29,-1.28,;-9.55,-.39,;-10.75,-1.04,;-9.41,1.14,;-8.02,1.79,;-.09,3.22,;-.09,1.68,;1.25,.91,;2.58,1.68,;2.58,3.22,;1.25,3.99,;3.91,.91,;4.07,2.44,;5.32,1.53,;6.35,.39,;5.58,-.94,;6.21,-2.35,;7.74,-2.34,;8.44,-3.63,;7.67,-4.96,;8.44,-6.3,;9.98,-6.3,;10.75,-4.96,;9.98,-3.63,;4.07,-.62,)| Show InChI InChI=1S/C29H39N5O3/c30-27-26(28(36)32-24-5-7-25(35)8-6-24)15-21(17-31-27)20-1-3-22(4-2-20)29-16-23(29)18-34(19-29)10-9-33-11-13-37-14-12-33/h1-4,15,17,23-25,35H,5-14,16,18-19H2,(H2,30,31)(H,32,36)/t23-,24-,25-,29+/m1/s1 | UniProtKB/SwissProt
GoogleScholar
AffyNet
| PC cid
PC sid
UniChem
| US Patent
| n/a | n/a | 1.40E+3 | n/a | n/a | n/a | n/a | n/a | n/a |
Novartis AG
US Patent
| Assay Description
The assays were performed in 384-well, low volume microtiter assay plates in a final reaction volume of 6 ul. Dose-response curves were generated by ... |
US Patent US10710980 (2020)
|
More data for this
Ligand-Target Pair | |
Activin receptor type-1 [172-499]
(Homo sapiens (Human)) | BDBM451778
(US10710980, Example 10 | US10947218, Example 10)Show SMILES Nc1ncc(cc1C(=O)N[C@H]1CC[C@H](O)CC1)-c1ccc(cc1)[C@@]12C[C@@H]1CN(CCN1CCOCC1)C2 |r,wU:23.25,10.10,wD:25.27,13.14,(-5.42,6.3,;-4.09,5.53,;-2.75,6.3,;-1.42,5.53,;-1.42,3.99,;-2.75,3.22,;-4.09,3.99,;-5.42,3.22,;-6.76,3.99,;-5.42,1.68,;-6.76,.91,;-6.89,-.63,;-8.29,-1.28,;-9.55,-.39,;-10.75,-1.04,;-9.41,1.14,;-8.02,1.79,;-.09,3.22,;-.09,1.68,;1.25,.91,;2.58,1.68,;2.58,3.22,;1.25,3.99,;3.91,.91,;4.07,2.44,;5.32,1.53,;6.35,.39,;5.58,-.94,;6.21,-2.35,;7.74,-2.34,;8.44,-3.63,;7.67,-4.96,;8.44,-6.3,;9.98,-6.3,;10.75,-4.96,;9.98,-3.63,;4.07,-.62,)| Show InChI InChI=1S/C29H39N5O3/c30-27-26(28(36)32-24-5-7-25(35)8-6-24)15-21(17-31-27)20-1-3-22(4-2-20)29-16-23(29)18-34(19-29)10-9-33-11-13-37-14-12-33/h1-4,15,17,23-25,35H,5-14,16,18-19H2,(H2,30,31)(H,32,36)/t23-,24-,25-,29+/m1/s1 | PDB
UniProtKB/SwissProt
GoogleScholar
AffyNet
| PC cid
PC sid
UniChem
| US Patent
| n/a | n/a | 11 | n/a | n/a | n/a | n/a | n/a | n/a |
Novartis AG
US Patent
| Assay Description
In the applied method, this separation takes place inside a chip that contains a complex capillary system for simultaneous analysis of 12 samples (“1... |
US Patent US10710980 (2020)
|
More data for this
Ligand-Target Pair | |
Activin receptor type-1 [172-499,R206H]
(Homo sapiens (Human)) | BDBM451778
(US10710980, Example 10 | US10947218, Example 10)Show SMILES Nc1ncc(cc1C(=O)N[C@H]1CC[C@H](O)CC1)-c1ccc(cc1)[C@@]12C[C@@H]1CN(CCN1CCOCC1)C2 |r,wU:23.25,10.10,wD:25.27,13.14,(-5.42,6.3,;-4.09,5.53,;-2.75,6.3,;-1.42,5.53,;-1.42,3.99,;-2.75,3.22,;-4.09,3.99,;-5.42,3.22,;-6.76,3.99,;-5.42,1.68,;-6.76,.91,;-6.89,-.63,;-8.29,-1.28,;-9.55,-.39,;-10.75,-1.04,;-9.41,1.14,;-8.02,1.79,;-.09,3.22,;-.09,1.68,;1.25,.91,;2.58,1.68,;2.58,3.22,;1.25,3.99,;3.91,.91,;4.07,2.44,;5.32,1.53,;6.35,.39,;5.58,-.94,;6.21,-2.35,;7.74,-2.34,;8.44,-3.63,;7.67,-4.96,;8.44,-6.3,;9.98,-6.3,;10.75,-4.96,;9.98,-3.63,;4.07,-.62,)| Show InChI InChI=1S/C29H39N5O3/c30-27-26(28(36)32-24-5-7-25(35)8-6-24)15-21(17-31-27)20-1-3-22(4-2-20)29-16-23(29)18-34(19-29)10-9-33-11-13-37-14-12-33/h1-4,15,17,23-25,35H,5-14,16,18-19H2,(H2,30,31)(H,32,36)/t23-,24-,25-,29+/m1/s1 | PDB
UniProtKB/SwissProt
GoogleScholar
AffyNet
| PC cid
PC sid
UniChem
| US Patent
| n/a | n/a | 13 | n/a | n/a | n/a | n/a | n/a | n/a |
Novartis AG
US Patent
| Assay Description
In the applied method, this separation takes place inside a chip that contains a complex capillary system for simultaneous analysis of 12 samples (“1... |
US Patent US10710980 (2020)
|
More data for this
Ligand-Target Pair | |
Serine/threonine-protein kinase receptor R3 [166-493]
(Homo sapiens (Human)) | BDBM451778
(US10710980, Example 10 | US10947218, Example 10)Show SMILES Nc1ncc(cc1C(=O)N[C@H]1CC[C@H](O)CC1)-c1ccc(cc1)[C@@]12C[C@@H]1CN(CCN1CCOCC1)C2 |r,wU:23.25,10.10,wD:25.27,13.14,(-5.42,6.3,;-4.09,5.53,;-2.75,6.3,;-1.42,5.53,;-1.42,3.99,;-2.75,3.22,;-4.09,3.99,;-5.42,3.22,;-6.76,3.99,;-5.42,1.68,;-6.76,.91,;-6.89,-.63,;-8.29,-1.28,;-9.55,-.39,;-10.75,-1.04,;-9.41,1.14,;-8.02,1.79,;-.09,3.22,;-.09,1.68,;1.25,.91,;2.58,1.68,;2.58,3.22,;1.25,3.99,;3.91,.91,;4.07,2.44,;5.32,1.53,;6.35,.39,;5.58,-.94,;6.21,-2.35,;7.74,-2.34,;8.44,-3.63,;7.67,-4.96,;8.44,-6.3,;9.98,-6.3,;10.75,-4.96,;9.98,-3.63,;4.07,-.62,)| Show InChI InChI=1S/C29H39N5O3/c30-27-26(28(36)32-24-5-7-25(35)8-6-24)15-21(17-31-27)20-1-3-22(4-2-20)29-16-23(29)18-34(19-29)10-9-33-11-13-37-14-12-33/h1-4,15,17,23-25,35H,5-14,16,18-19H2,(H2,30,31)(H,32,36)/t23-,24-,25-,29+/m1/s1 | PDB
MMDB
NCI pathway
Reactome pathway
KEGG
UniProtKB/SwissProt
B.MOAD
DrugBank
GoogleScholar
AffyNet
| PC cid
PC sid
UniChem
| US Patent
| n/a | n/a | 89 | n/a | n/a | n/a | n/a | n/a | n/a |
Novartis AG
US Patent
| Assay Description
In the applied method, this separation takes place inside a chip that contains a complex capillary system for simultaneous analysis of 12 samples (“1... |
US Patent US10710980 (2020)
|
More data for this
Ligand-Target Pair | |
TGF-beta receptor type-1 [162-503]
(Homo sapiens (Human)) | BDBM451778
(US10710980, Example 10 | US10947218, Example 10)Show SMILES Nc1ncc(cc1C(=O)N[C@H]1CC[C@H](O)CC1)-c1ccc(cc1)[C@@]12C[C@@H]1CN(CCN1CCOCC1)C2 |r,wU:23.25,10.10,wD:25.27,13.14,(-5.42,6.3,;-4.09,5.53,;-2.75,6.3,;-1.42,5.53,;-1.42,3.99,;-2.75,3.22,;-4.09,3.99,;-5.42,3.22,;-6.76,3.99,;-5.42,1.68,;-6.76,.91,;-6.89,-.63,;-8.29,-1.28,;-9.55,-.39,;-10.75,-1.04,;-9.41,1.14,;-8.02,1.79,;-.09,3.22,;-.09,1.68,;1.25,.91,;2.58,1.68,;2.58,3.22,;1.25,3.99,;3.91,.91,;4.07,2.44,;5.32,1.53,;6.35,.39,;5.58,-.94,;6.21,-2.35,;7.74,-2.34,;8.44,-3.63,;7.67,-4.96,;8.44,-6.3,;9.98,-6.3,;10.75,-4.96,;9.98,-3.63,;4.07,-.62,)| Show InChI InChI=1S/C29H39N5O3/c30-27-26(28(36)32-24-5-7-25(35)8-6-24)15-21(17-31-27)20-1-3-22(4-2-20)29-16-23(29)18-34(19-29)10-9-33-11-13-37-14-12-33/h1-4,15,17,23-25,35H,5-14,16,18-19H2,(H2,30,31)(H,32,36)/t23-,24-,25-,29+/m1/s1 | PDB
UniProtKB/SwissProt
GoogleScholar
AffyNet
| PC cid
PC sid
UniChem
| US Patent
| n/a | n/a | 2.60E+3 | n/a | n/a | n/a | n/a | n/a | n/a |
Novartis AG
US Patent
| Assay Description
In the applied method, this separation takes place inside a chip that contains a complex capillary system for simultaneous analysis of 12 samples (“1... |
US Patent US10710980 (2020)
|
More data for this
Ligand-Target Pair | |
Bone morphogenetic protein receptor type-1B
(Homo sapiens (Human)) | BDBM451778
(US10710980, Example 10 | US10947218, Example 10)Show SMILES Nc1ncc(cc1C(=O)N[C@H]1CC[C@H](O)CC1)-c1ccc(cc1)[C@@]12C[C@@H]1CN(CCN1CCOCC1)C2 |r,wU:23.25,10.10,wD:25.27,13.14,(-5.42,6.3,;-4.09,5.53,;-2.75,6.3,;-1.42,5.53,;-1.42,3.99,;-2.75,3.22,;-4.09,3.99,;-5.42,3.22,;-6.76,3.99,;-5.42,1.68,;-6.76,.91,;-6.89,-.63,;-8.29,-1.28,;-9.55,-.39,;-10.75,-1.04,;-9.41,1.14,;-8.02,1.79,;-.09,3.22,;-.09,1.68,;1.25,.91,;2.58,1.68,;2.58,3.22,;1.25,3.99,;3.91,.91,;4.07,2.44,;5.32,1.53,;6.35,.39,;5.58,-.94,;6.21,-2.35,;7.74,-2.34,;8.44,-3.63,;7.67,-4.96,;8.44,-6.3,;9.98,-6.3,;10.75,-4.96,;9.98,-3.63,;4.07,-.62,)| Show InChI InChI=1S/C29H39N5O3/c30-27-26(28(36)32-24-5-7-25(35)8-6-24)15-21(17-31-27)20-1-3-22(4-2-20)29-16-23(29)18-34(19-29)10-9-33-11-13-37-14-12-33/h1-4,15,17,23-25,35H,5-14,16,18-19H2,(H2,30,31)(H,32,36)/t23-,24-,25-,29+/m1/s1 | PDB
UniProtKB/SwissProt
antibodypedia
GoogleScholar
AffyNet
| PC cid
PC sid
UniChem
| US Patent
| n/a | n/a | 2.50E+3 | n/a | n/a | n/a | n/a | n/a | n/a |
NOVARTIS AG
US Patent
| Assay Description
A kinase selectivity panel which measures substrate peptide phosphorylation was set-up for wild-type ALK2 (aa172-499), ALK2 FOP mutant (aa172-499 R20... |
US Patent US10947218 (2021)
|
More data for this
Ligand-Target Pair | |
Activin receptor type-1 [172-499]
(Homo sapiens (Human)) | BDBM451778
(US10710980, Example 10 | US10947218, Example 10)Show SMILES Nc1ncc(cc1C(=O)N[C@H]1CC[C@H](O)CC1)-c1ccc(cc1)[C@@]12C[C@@H]1CN(CCN1CCOCC1)C2 |r,wU:23.25,10.10,wD:25.27,13.14,(-5.42,6.3,;-4.09,5.53,;-2.75,6.3,;-1.42,5.53,;-1.42,3.99,;-2.75,3.22,;-4.09,3.99,;-5.42,3.22,;-6.76,3.99,;-5.42,1.68,;-6.76,.91,;-6.89,-.63,;-8.29,-1.28,;-9.55,-.39,;-10.75,-1.04,;-9.41,1.14,;-8.02,1.79,;-.09,3.22,;-.09,1.68,;1.25,.91,;2.58,1.68,;2.58,3.22,;1.25,3.99,;3.91,.91,;4.07,2.44,;5.32,1.53,;6.35,.39,;5.58,-.94,;6.21,-2.35,;7.74,-2.34,;8.44,-3.63,;7.67,-4.96,;8.44,-6.3,;9.98,-6.3,;10.75,-4.96,;9.98,-3.63,;4.07,-.62,)| Show InChI InChI=1S/C29H39N5O3/c30-27-26(28(36)32-24-5-7-25(35)8-6-24)15-21(17-31-27)20-1-3-22(4-2-20)29-16-23(29)18-34(19-29)10-9-33-11-13-37-14-12-33/h1-4,15,17,23-25,35H,5-14,16,18-19H2,(H2,30,31)(H,32,36)/t23-,24-,25-,29+/m1/s1 | PDB
UniProtKB/SwissProt
GoogleScholar
AffyNet
| PC cid
PC sid
UniChem
| US Patent
| n/a | n/a | 11 | n/a | n/a | n/a | n/a | n/a | n/a |
NOVARTIS AG
US Patent
| Assay Description
A kinase selectivity panel which measures autophosphorylation using the ADP-Glo Kinase Assay (Promega, V9101) was set-up for wild-type ALK2 (aa172-49... |
US Patent US10947218 (2021)
|
More data for this
Ligand-Target Pair | |
Bone morphogenetic protein receptor type-1A [198-525]
(Homo sapiens (Human)) | BDBM451778
(US10710980, Example 10 | US10947218, Example 10)Show SMILES Nc1ncc(cc1C(=O)N[C@H]1CC[C@H](O)CC1)-c1ccc(cc1)[C@@]12C[C@@H]1CN(CCN1CCOCC1)C2 |r,wU:23.25,10.10,wD:25.27,13.14,(-5.42,6.3,;-4.09,5.53,;-2.75,6.3,;-1.42,5.53,;-1.42,3.99,;-2.75,3.22,;-4.09,3.99,;-5.42,3.22,;-6.76,3.99,;-5.42,1.68,;-6.76,.91,;-6.89,-.63,;-8.29,-1.28,;-9.55,-.39,;-10.75,-1.04,;-9.41,1.14,;-8.02,1.79,;-.09,3.22,;-.09,1.68,;1.25,.91,;2.58,1.68,;2.58,3.22,;1.25,3.99,;3.91,.91,;4.07,2.44,;5.32,1.53,;6.35,.39,;5.58,-.94,;6.21,-2.35,;7.74,-2.34,;8.44,-3.63,;7.67,-4.96,;8.44,-6.3,;9.98,-6.3,;10.75,-4.96,;9.98,-3.63,;4.07,-.62,)| Show InChI InChI=1S/C29H39N5O3/c30-27-26(28(36)32-24-5-7-25(35)8-6-24)15-21(17-31-27)20-1-3-22(4-2-20)29-16-23(29)18-34(19-29)10-9-33-11-13-37-14-12-33/h1-4,15,17,23-25,35H,5-14,16,18-19H2,(H2,30,31)(H,32,36)/t23-,24-,25-,29+/m1/s1 | UniProtKB/SwissProt
GoogleScholar
AffyNet
| PC cid
PC sid
UniChem
| US Patent
| n/a | n/a | 1.40E+3 | n/a | n/a | n/a | n/a | n/a | n/a |
NOVARTIS AG
US Patent
| Assay Description
A kinase selectivity panel which measures autophosphorylation using the ADP-Glo Kinase Assay (Promega, V9101) was set-up for wild-type ALK2 (aa172-49... |
US Patent US10947218 (2021)
|
More data for this
Ligand-Target Pair | |
Activin receptor type-1 [172-499]
(Homo sapiens (Human)) | BDBM451778
(US10710980, Example 10 | US10947218, Example 10)Show SMILES Nc1ncc(cc1C(=O)N[C@H]1CC[C@H](O)CC1)-c1ccc(cc1)[C@@]12C[C@@H]1CN(CCN1CCOCC1)C2 |r,wU:23.25,10.10,wD:25.27,13.14,(-5.42,6.3,;-4.09,5.53,;-2.75,6.3,;-1.42,5.53,;-1.42,3.99,;-2.75,3.22,;-4.09,3.99,;-5.42,3.22,;-6.76,3.99,;-5.42,1.68,;-6.76,.91,;-6.89,-.63,;-8.29,-1.28,;-9.55,-.39,;-10.75,-1.04,;-9.41,1.14,;-8.02,1.79,;-.09,3.22,;-.09,1.68,;1.25,.91,;2.58,1.68,;2.58,3.22,;1.25,3.99,;3.91,.91,;4.07,2.44,;5.32,1.53,;6.35,.39,;5.58,-.94,;6.21,-2.35,;7.74,-2.34,;8.44,-3.63,;7.67,-4.96,;8.44,-6.3,;9.98,-6.3,;10.75,-4.96,;9.98,-3.63,;4.07,-.62,)| Show InChI InChI=1S/C29H39N5O3/c30-27-26(28(36)32-24-5-7-25(35)8-6-24)15-21(17-31-27)20-1-3-22(4-2-20)29-16-23(29)18-34(19-29)10-9-33-11-13-37-14-12-33/h1-4,15,17,23-25,35H,5-14,16,18-19H2,(H2,30,31)(H,32,36)/t23-,24-,25-,29+/m1/s1 | PDB
UniProtKB/SwissProt
GoogleScholar
AffyNet
| PC cid
PC sid
UniChem
| US Patent
| n/a | n/a | 11 | n/a | n/a | n/a | n/a | n/a | n/a |
NOVARTIS AG
US Patent
| Assay Description
A kinase selectivity panel which measures substrate peptide phosphorylation was set-up for wild-type ALK2 (aa172-499), ALK2 FOP mutant (aa172-499 R20... |
US Patent US10947218 (2021)
|
More data for this
Ligand-Target Pair | |
Activin receptor type-1 [172-499,R206H]
(Homo sapiens (Human)) | BDBM451778
(US10710980, Example 10 | US10947218, Example 10)Show SMILES Nc1ncc(cc1C(=O)N[C@H]1CC[C@H](O)CC1)-c1ccc(cc1)[C@@]12C[C@@H]1CN(CCN1CCOCC1)C2 |r,wU:23.25,10.10,wD:25.27,13.14,(-5.42,6.3,;-4.09,5.53,;-2.75,6.3,;-1.42,5.53,;-1.42,3.99,;-2.75,3.22,;-4.09,3.99,;-5.42,3.22,;-6.76,3.99,;-5.42,1.68,;-6.76,.91,;-6.89,-.63,;-8.29,-1.28,;-9.55,-.39,;-10.75,-1.04,;-9.41,1.14,;-8.02,1.79,;-.09,3.22,;-.09,1.68,;1.25,.91,;2.58,1.68,;2.58,3.22,;1.25,3.99,;3.91,.91,;4.07,2.44,;5.32,1.53,;6.35,.39,;5.58,-.94,;6.21,-2.35,;7.74,-2.34,;8.44,-3.63,;7.67,-4.96,;8.44,-6.3,;9.98,-6.3,;10.75,-4.96,;9.98,-3.63,;4.07,-.62,)| Show InChI InChI=1S/C29H39N5O3/c30-27-26(28(36)32-24-5-7-25(35)8-6-24)15-21(17-31-27)20-1-3-22(4-2-20)29-16-23(29)18-34(19-29)10-9-33-11-13-37-14-12-33/h1-4,15,17,23-25,35H,5-14,16,18-19H2,(H2,30,31)(H,32,36)/t23-,24-,25-,29+/m1/s1 | PDB
UniProtKB/SwissProt
GoogleScholar
AffyNet
| PC cid
PC sid
UniChem
| US Patent
| n/a | n/a | 13 | n/a | n/a | n/a | n/a | n/a | n/a |
NOVARTIS AG
US Patent
| Assay Description
A kinase selectivity panel which measures substrate peptide phosphorylation was set-up for wild-type ALK2 (aa172-499), ALK2 FOP mutant (aa172-499 R20... |
US Patent US10947218 (2021)
|
More data for this
Ligand-Target Pair | |
Serine/threonine-protein kinase receptor R3 [166-493]
(Homo sapiens (Human)) | BDBM451778
(US10710980, Example 10 | US10947218, Example 10)Show SMILES Nc1ncc(cc1C(=O)N[C@H]1CC[C@H](O)CC1)-c1ccc(cc1)[C@@]12C[C@@H]1CN(CCN1CCOCC1)C2 |r,wU:23.25,10.10,wD:25.27,13.14,(-5.42,6.3,;-4.09,5.53,;-2.75,6.3,;-1.42,5.53,;-1.42,3.99,;-2.75,3.22,;-4.09,3.99,;-5.42,3.22,;-6.76,3.99,;-5.42,1.68,;-6.76,.91,;-6.89,-.63,;-8.29,-1.28,;-9.55,-.39,;-10.75,-1.04,;-9.41,1.14,;-8.02,1.79,;-.09,3.22,;-.09,1.68,;1.25,.91,;2.58,1.68,;2.58,3.22,;1.25,3.99,;3.91,.91,;4.07,2.44,;5.32,1.53,;6.35,.39,;5.58,-.94,;6.21,-2.35,;7.74,-2.34,;8.44,-3.63,;7.67,-4.96,;8.44,-6.3,;9.98,-6.3,;10.75,-4.96,;9.98,-3.63,;4.07,-.62,)| Show InChI InChI=1S/C29H39N5O3/c30-27-26(28(36)32-24-5-7-25(35)8-6-24)15-21(17-31-27)20-1-3-22(4-2-20)29-16-23(29)18-34(19-29)10-9-33-11-13-37-14-12-33/h1-4,15,17,23-25,35H,5-14,16,18-19H2,(H2,30,31)(H,32,36)/t23-,24-,25-,29+/m1/s1 | PDB
MMDB
NCI pathway
Reactome pathway
KEGG
UniProtKB/SwissProt
B.MOAD
DrugBank
GoogleScholar
AffyNet
| PC cid
PC sid
UniChem
| US Patent
| n/a | n/a | 89 | n/a | n/a | n/a | n/a | n/a | n/a |
NOVARTIS AG
US Patent
| Assay Description
A kinase selectivity panel which measures substrate peptide phosphorylation was set-up for wild-type ALK2 (aa172-499), ALK2 FOP mutant (aa172-499 R20... |
US Patent US10947218 (2021)
|
More data for this
Ligand-Target Pair | |
TGF-beta receptor type-1 [162-503]
(Homo sapiens (Human)) | BDBM451778
(US10710980, Example 10 | US10947218, Example 10)Show SMILES Nc1ncc(cc1C(=O)N[C@H]1CC[C@H](O)CC1)-c1ccc(cc1)[C@@]12C[C@@H]1CN(CCN1CCOCC1)C2 |r,wU:23.25,10.10,wD:25.27,13.14,(-5.42,6.3,;-4.09,5.53,;-2.75,6.3,;-1.42,5.53,;-1.42,3.99,;-2.75,3.22,;-4.09,3.99,;-5.42,3.22,;-6.76,3.99,;-5.42,1.68,;-6.76,.91,;-6.89,-.63,;-8.29,-1.28,;-9.55,-.39,;-10.75,-1.04,;-9.41,1.14,;-8.02,1.79,;-.09,3.22,;-.09,1.68,;1.25,.91,;2.58,1.68,;2.58,3.22,;1.25,3.99,;3.91,.91,;4.07,2.44,;5.32,1.53,;6.35,.39,;5.58,-.94,;6.21,-2.35,;7.74,-2.34,;8.44,-3.63,;7.67,-4.96,;8.44,-6.3,;9.98,-6.3,;10.75,-4.96,;9.98,-3.63,;4.07,-.62,)| Show InChI InChI=1S/C29H39N5O3/c30-27-26(28(36)32-24-5-7-25(35)8-6-24)15-21(17-31-27)20-1-3-22(4-2-20)29-16-23(29)18-34(19-29)10-9-33-11-13-37-14-12-33/h1-4,15,17,23-25,35H,5-14,16,18-19H2,(H2,30,31)(H,32,36)/t23-,24-,25-,29+/m1/s1 | PDB
UniProtKB/SwissProt
GoogleScholar
AffyNet
| PC cid
PC sid
UniChem
| US Patent
| n/a | n/a | 2.60E+3 | n/a | n/a | n/a | n/a | n/a | n/a |
NOVARTIS AG
US Patent
| Assay Description
A kinase selectivity panel which measures substrate peptide phosphorylation was set-up for wild-type ALK2 (aa172-499), ALK2 FOP mutant (aa172-499 R20... |
US Patent US10947218 (2021)
|
More data for this
Ligand-Target Pair | |
Bone morphogenetic protein receptor type-1B
(Homo sapiens (Human)) | BDBM451778
(US10710980, Example 10 | US10947218, Example 10)Show SMILES Nc1ncc(cc1C(=O)N[C@H]1CC[C@H](O)CC1)-c1ccc(cc1)[C@@]12C[C@@H]1CN(CCN1CCOCC1)C2 |r,wU:23.25,10.10,wD:25.27,13.14,(-5.42,6.3,;-4.09,5.53,;-2.75,6.3,;-1.42,5.53,;-1.42,3.99,;-2.75,3.22,;-4.09,3.99,;-5.42,3.22,;-6.76,3.99,;-5.42,1.68,;-6.76,.91,;-6.89,-.63,;-8.29,-1.28,;-9.55,-.39,;-10.75,-1.04,;-9.41,1.14,;-8.02,1.79,;-.09,3.22,;-.09,1.68,;1.25,.91,;2.58,1.68,;2.58,3.22,;1.25,3.99,;3.91,.91,;4.07,2.44,;5.32,1.53,;6.35,.39,;5.58,-.94,;6.21,-2.35,;7.74,-2.34,;8.44,-3.63,;7.67,-4.96,;8.44,-6.3,;9.98,-6.3,;10.75,-4.96,;9.98,-3.63,;4.07,-.62,)| Show InChI InChI=1S/C29H39N5O3/c30-27-26(28(36)32-24-5-7-25(35)8-6-24)15-21(17-31-27)20-1-3-22(4-2-20)29-16-23(29)18-34(19-29)10-9-33-11-13-37-14-12-33/h1-4,15,17,23-25,35H,5-14,16,18-19H2,(H2,30,31)(H,32,36)/t23-,24-,25-,29+/m1/s1 | PDB
UniProtKB/SwissProt
antibodypedia
GoogleScholar
AffyNet
| PC cid
PC sid
UniChem
| US Patent
| n/a | n/a | 2.50E+3 | n/a | n/a | n/a | n/a | n/a | n/a |
Novartis AG
US Patent
| Assay Description
In the applied method, this separation takes place inside a chip that contains a complex capillary system for simultaneous analysis of 12 samples (“1... |
US Patent US10710980 (2020)
|
More data for this
Ligand-Target Pair | |
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