BDBM452570 3-((3-((3R,5R)-5-(4- chlorophenyl)tetra- hydrofuran-3-yl)-1,2,4- oxadiazol-5-yl)methyl)- 5-methylpyrazolo[5,1- f][1,2,4]triazin-4(3H)- one::US10710994, Example 48
SMILES: Cc1cnn2ncn(Cc3nc(no3)[C@@H]3CO[C@H](C3)c3ccc(Cl)cc3)c(=O)c12
InChI Key: InChIKey=HWKOCGQYCSKFFR-DZGCQCFKSA-N
Data: 2 IC50
Target/Host (Institution) | Ligand | Target/Host Links | Ligand Links | Trg + Lig Links | Ki nM | ΔG° kcal/mole | IC50 nM | Kd nM | EC50/IC50 nM | koff s-1 | kon M-1s-1 | pH | Temp °C |
---|---|---|---|---|---|---|---|---|---|---|---|---|---|
Transient receptor potential cation channel subfamily A member 1 (Homo sapiens (Human)) | BDBM452570 (3-((3-((3R,5R)-5-(4- chlorophenyl)tetra- hydrofura...) | PDB KEGG UniProtKB/SwissProt DrugBank antibodypedia GoogleScholar AffyNet | PC cid PC sid UniChem | US Patent | n/a | n/a | 0.800 | n/a | n/a | n/a | n/a | n/a | n/a |
Genentech, Inc. US Patent | Assay Description The IC50 (effective concentration) of compounds on the human TRPA1 channel was determined using a FLIPR Tetra instrument. CHO cells expressing TRPA1 ... | US Patent US10710994 (2020) | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Transient receptor potential cation channel subfamily A member 1 (Homo sapiens (Human)) | BDBM452570 (3-((3-((3R,5R)-5-(4- chlorophenyl)tetra- hydrofura...) | PDB KEGG UniProtKB/SwissProt DrugBank antibodypedia GoogleScholar AffyNet | PC cid PC sid UniChem | US Patent | n/a | n/a | 1.20 | n/a | n/a | n/a | n/a | n/a | n/a |
Genentech, Inc. US Patent | Assay Description The IC50 (effective concentration) of compounds on the human TRPA1 channel was determined using a FLIPR Tetra instrument. CHO cells expressing TRPA1 ... | US Patent US10710994 (2020) | |||||||||||
More data for this Ligand-Target Pair |