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SMILES: CC(C)[C@H](NC(=O)Nc1cccc(Cl)c1)C(=O)N1CCC[C@H]1C(=O)N[C@@H](CCCNC(N)=N)C(=O)CF

InChI Key: InChIKey=PGNDIRZMSSDLLY-BJLQDIEVSA-N

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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 1 hit for monomerid = 453114   
Target/Host
(Institution)		LigandTarget/Host
Links		Ligand
Links		Trg + Lig
Links		Ki
nM		ΔG°
kcal/mole		IC50
nM		Kd
nM		EC50/IC50
nM		koff
s-1		kon
M-1s-1		pHTemp
°C
Mucosa-associated lymphoid tissue lymphoma translocation protein 1


(Homo sapiens (Human))		BDBM453114
PNG
(US10711036, Compound 165)
Show SMILES CC(C)[C@H](NC(=O)Nc1cccc(Cl)c1)C(=O)N1CCC[C@H]1C(=O)N[C@@H](CCCNC(N)=N)C(=O)CF |r|
Show InChI InChI=1S/C24H35ClFN7O4/c1-14(2)20(32-24(37)30-16-7-3-6-15(25)12-16)22(36)33-11-5-9-18(33)21(35)31-17(19(34)13-26)8-4-10-29-23(27)28/h3,6-7,12,14,17-18,20H,4-5,8-11,13H2,1-2H3,(H,31,35)(H4,27,28,29)(H2,30,32,37)/t17-,18-,20-/m0/s1
PDB

UniProtKB/SwissProt

GoogleScholar
AffyNet 
PC cid
PC sid
UniChem
US Patent
 27n/an/an/an/an/an/an/an/a



Cornell University; Dana-Farber Cancer Institute, Inc.; Children''s Medical Center Corporation

US Patent


Assay Description
For exemplary compounds of the disclosure, Ki for inhibition of MALT1 was measured (Table E11). A concentration of 100 nM MALT1 was used for the assa...

US Patent US10711036 (2020)

More data for this
Ligand-Target Pair