BDBM454801 US10730868, Ex. No. 68::US10730868, Ex. No. 71

SMILES: COc1cnc2c(cc(C)cc2n1)-c1nc2cc(F)c(O[C@@H]3CC[C@@H]3OC(=O)Nc3cnc(OCCO)nc3)cc2s1

InChI Key: InChIKey=VLXRYXLYQGFBMQ-RTWAWAEBSA-N

Data: 2 IC50

Find this compound or compounds like it in BindingDB or PDB:

Substructure Similarity at least:  must be >=0.5 Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 2 hits for monomerid = 454801   

Target/Host (Institution)	Ligand	Target/Host Links	Ligand Links	Trg + Lig Links	Ki nM	ΔG° kcal/mole	IC50 nM	Kd nM	EC50/IC50 nM	koff s-1	kon M-1s-1	pH	Temp °C
Proteinase-activated receptor 4 (Homo sapiens (Human))	BDBM454801 (US10730868, Ex. No. 68 | US10730868, Ex. No. 71) Show SMILES COc1cnc2c(cc(C)cc2n1)-c1nc2cc(F)c(O[C@@H]3CC[C@@H]3OC(=O)Nc3cnc(OCCO)nc3)cc2s1 |r| Show InChI InChI=1S/C28H25FN6O6S/c1-14-7-16(25-19(8-14)34-24(38-2)13-30-25)26-35-18-9-17(29)22(10-23(18)42-26)40-20-3-4-21(20)41-28(37)33-15-11-31-27(32-12-15)39-6-5-36/h7-13,20-21,36H,3-6H2,1-2H3,(H,33,37)/t20-,21+/m1/s1	UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	1.60	n/a	n/a	n/a	n/a	n/a	n/a
Bristol-Myers Squibb Company US Patent					Assay Description FLIPR-based calcium mobilization assay in HEK293 cells was used to measure PAR4 antagonism agonism, and selectivity against PAR1. The activity of the...				US Patent US10730868 (2020)
					More data for this Ligand-Target Pair
Proteinase-activated receptor 4 (Homo sapiens (Human))	BDBM454801 (US10730868, Ex. No. 68 | US10730868, Ex. No. 71) Show SMILES COc1cnc2c(cc(C)cc2n1)-c1nc2cc(F)c(O[C@@H]3CC[C@@H]3OC(=O)Nc3cnc(OCCO)nc3)cc2s1 |r| Show InChI InChI=1S/C28H25FN6O6S/c1-14-7-16(25-19(8-14)34-24(38-2)13-30-25)26-35-18-9-17(29)22(10-23(18)42-26)40-20-3-4-21(20)41-28(37)33-15-11-31-27(32-12-15)39-6-5-36/h7-13,20-21,36H,3-6H2,1-2H3,(H,33,37)/t20-,21+/m1/s1	UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	0.75	n/a	n/a	n/a	n/a	n/a	n/a
Bristol-Myers Squibb Company US Patent					Assay Description FLIPR-based calcium mobilization assay in HEK293 cells was used to measure PAR4 antagonism agonism, and selectivity against PAR1. The activity of the...				US Patent US10730868 (2020)
					More data for this Ligand-Target Pair