BDBM455350 7-(2,4-Difluorophenyl)-N4,5,5-trimethyl-N2-((1R,5S,8s)-3-(5-methyl-1,3,4-oxadiazol-2-yl)-3-azabicyclo[3.2.1]octan-8-yl)-6,7-dihydro-5H-pyrrolo[2,3-d]pyrimidine-2,4-diamine::US10730881, Example 16

SMILES: CNc1nc(NC2C3CCC2CN(C3)c2nnc(C)o2)nc2N(CC(C)(C)c12)c1ccc(F)cc1F

InChI Key: InChIKey=NOKYTENGDTXUOG-UHFFFAOYSA-N

Data: 1 EC50

Find this compound or compounds like it in BindingDB or PDB:

Substructure Similarity at least:  must be >=0.5 Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 1 hit for monomerid = 455350   

Target/Host (Institution)	Ligand	Target/Host Links	Ligand Links	Trg + Lig Links	Ki nM	ΔG° kcal/mole	IC50 nM	Kd nM	EC50/IC50 nM	koff s-1	kon M-1s-1	pH	Temp °C
Amyloid-beta precursor protein (Homo sapiens (Human))	BDBM455350 (7-(2,4-Difluorophenyl)-N4,5,5-trimethyl-N2-((1R,5S...) Show SMILES CNc1nc(NC2C3CCC2CN(C3)c2nnc(C)o2)nc2N(CC(C)(C)c12)c1ccc(F)cc1F |TLB:14:12:6:8.9,5:6:12.11.13:8.9| Show InChI InChI=1S/C25H30F2N8O/c1-13-32-33-24(36-13)34-10-14-5-6-15(11-34)20(14)29-23-30-21(28-4)19-22(31-23)35(12-25(19,2)3)18-8-7-16(26)9-17(18)27/h7-9,14-15,20H,5-6,10-12H2,1-4H3,(H2,28,29,30,31)	PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt UniProtKB/TrEMBL B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	n/a	n/a	31	n/a	n/a	n/a	n/a
HOFFMANN-LA ROCHE, INC. US Patent					Assay Description Human neuroglioma H4 cells overexpressing human APP695 with the Swedish double mutation (K595N/M596L) were plated at 30,000 cells/well/100 μl in...				US Patent US10730881 (2020)
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