BDBM455352 N2-((1R,5S,8s)-3-(6-Methoxypyridazin-4-yl)-3-azabicyclo[3.2.1]octan-8-yl)-N4,5,5-trimethyl-7-(3-(trifluoromethyl)bicyclo[1.1.1]pentan-1-yl)-6,7-dihydro-5H-pyrrolo[2,3-d]pyrimidine-2,4-diamine::US10730881, Example 18

SMILES: CNc1nc(NC2C3CCC2CN(C3)c2cnnc(OC)c2)nc2N(CC(C)(C)c12)C12CC(C1)(C2)C(F)(F)F

InChI Key: InChIKey=LBGYEEKULLCZRR-UHFFFAOYSA-N

Data: 1 EC50

Find this compound or compounds like it in BindingDB or PDB:

Substructure Similarity at least:  must be >=0.5 Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 1 hit for monomerid = 455352   

Target/Host (Institution)	Ligand	Target/Host Links	Ligand Links	Trg + Lig Links	Ki nM	ΔG° kcal/mole	IC50 nM	Kd nM	EC50/IC50 nM	koff s-1	kon M-1s-1	pH	Temp °C
Amyloid-beta precursor protein (Homo sapiens (Human))	BDBM455352 (N2-((1R,5S,8s)-3-(6-Methoxypyridazin-4-yl)-3-azabi...) Show SMILES CNc1nc(NC2C3CCC2CN(C3)c2cnnc(OC)c2)nc2N(CC(C)(C)c12)C12CC(C1)(C2)C(F)(F)F |TLB:14:12:6:8.9,5:6:12.11.13:8.9| Show InChI InChI=1S/C27H35F3N8O/c1-24(2)14-38(26-11-25(12-26,13-26)27(28,29)30)22-19(24)21(31-3)34-23(35-22)33-20-15-5-6-16(20)10-37(9-15)17-7-18(39-4)36-32-8-17/h7-8,15-16,20H,5-6,9-14H2,1-4H3,(H2,31,33,34,35)	PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt UniProtKB/TrEMBL B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	n/a	n/a	53	n/a	n/a	n/a	n/a
HOFFMANN-LA ROCHE, INC. US Patent					Assay Description Human neuroglioma H4 cells overexpressing human APP695 with the Swedish double mutation (K595N/M596L) were plated at 30,000 cells/well/100 μl in...				US Patent US10730881 (2020)
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