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SMILES: COc1cc(Nc2c(cnc3cc(OCCCn4ccnn4)c(OC)cc23)C#N)c(Cl)cc1Cl

InChI Key: InChIKey=ZMNWHIBSNZMHFB-UHFFFAOYSA-N

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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 1 hit for monomerid = 4562   
Target/Host
(Institution)		LigandTarget/Host
Links		Ligand
Links		Trg + Lig
Links		Ki
nM		ΔG°
kcal/mole		IC50
nM		Kd
nM		EC50/IC50
nM		koff
s-1		kon
M-1s-1		pHTemp
°C
Proto-oncogene tyrosine-protein kinase Src


(Homo sapiens (Human))		BDBM4562
PNG
(4-Phenylamino-3-quinolinecarbonitrile deriv. 31k |...)
Show SMILES COc1cc(Nc2c(cnc3cc(OCCCn4ccnn4)c(OC)cc23)C#N)c(Cl)cc1Cl
Show InChI InChI=1S/C23H20Cl2N6O3/c1-32-20-11-19(16(24)9-17(20)25)29-23-14(12-26)13-27-18-10-22(21(33-2)8-15(18)23)34-7-3-5-31-6-4-28-30-31/h4,6,8-11,13H,3,5,7H2,1-2H3,(H,27,29)
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Article
PubMed
n/an/a 1.90n/an/an/an/an/an/a



Wyeth-Ayerst Research



Assay Description
Src kinase activity was measured in an ELISA format. IC50 is the inhibitor concentration which inhibits 50% of kinase activity that catalyzes the tra...

J Med Chem 44: 3965-77 (2001)


Article DOI: 10.1021/jm0102250
BindingDB Entry DOI: 10.7270/Q2TD9VHP
More data for this
Ligand-Target Pair