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SMILES: N[C@H]1CCN(C1)C(=O)c1ccc(-c2cc3nnn(CC4(O)CCC4)c3c(Cl)c2F)c(c1)-c1ccc(C#N)c(F)c1

InChI Key: InChIKey=JRFXKUKRYQOLAI-IBGZPJMESA-N

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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 1 hit for monomerid = 456529   
Target/Host
(Institution)		LigandTarget/Host
Links		Ligand
Links		Trg + Lig
Links		Ki
nM		ΔG°
kcal/mole		IC50
nM		Kd
nM		EC50/IC50
nM		koff
s-1		kon
M-1s-1		pHTemp
°C
Lysine-specific histone demethylase 1A


(Homo sapiens (Human))		BDBM456529
PNG
(US10723742, Example 258)
Show SMILES N[C@H]1CCN(C1)C(=O)c1ccc(-c2cc3nnn(CC4(O)CCC4)c3c(Cl)c2F)c(c1)-c1ccc(C#N)c(F)c1
Show InChI InChI=1S/C29H25ClF2N6O2/c30-25-26(32)22(12-24-27(25)38(36-35-24)15-29(40)7-1-8-29)20-5-4-17(28(39)37-9-6-19(34)14-37)10-21(20)16-2-3-18(13-33)23(31)11-16/h2-5,10-12,19,40H,1,6-9,14-15,34H2/t19-/m0/s1
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US Patent
n/an/a 0.130n/an/an/an/an/an/a



Taiho Pharmaceutical Co., Ltd.

US Patent


Assay Description
The conditions for measuring inhibitory activity of compounds against LSD1 activity were determined with reference to a document available from the w...

US Patent US10723742 (2020)

More data for this
Ligand-Target Pair