null

SMILES: Cc1c(F)c(cc2nnn(CC3(O)CCC3)c12)-c1ccc(cc1-c1ccc(C#N)c(F)c1)C(=O)N1C2CCC1CC(N)C2

InChI Key: InChIKey=CYIYQAJJCKFHDX-UHFFFAOYSA-N

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 2 hits for monomerid = 456530   

Target/Host (Institution)	Ligand	Target/Host Links	Ligand Links	Trg + Lig Links	Ki nM	ΔG° kcal/mole	IC50 nM	Kd nM	EC50/IC50 nM	koff s-1	kon M-1s-1	pH	Temp °C
Lysine-specific histone demethylase 1A (Homo sapiens (Human))	BDBM456530 (US10723742, Example 259 | US10723742, Example 272) Show SMILES Cc1c(F)c(cc2nnn(CC3(O)CCC3)c12)-c1ccc(cc1-c1ccc(C#N)c(F)c1)C(=O)N1C2CCC1CC(N)C2 |THB:41:40:36.37:34| Show InChI InChI=1S/C33H32F2N6O2/c1-18-30(35)27(15-29-31(18)40(39-38-29)17-33(43)9-2-10-33)25-8-5-20(11-26(25)19-3-4-21(16-36)28(34)12-19)32(42)41-23-6-7-24(41)14-22(37)13-23/h3-5,8,11-12,15,22-24,43H,2,6-7,9-10,13-14,17,37H2,1H3	PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	0.320	n/a	n/a	n/a	n/a	n/a	n/a
Taiho Pharmaceutical Co., Ltd. US Patent					Assay Description The conditions for measuring inhibitory activity of compounds against LSD1 activity were determined with reference to a document available from the w...				US Patent US10723742 (2020)
					More data for this Ligand-Target Pair
Lysine-specific histone demethylase 1A (Homo sapiens (Human))	BDBM456530 (US10723742, Example 259 | US10723742, Example 272) Show SMILES Cc1c(F)c(cc2nnn(CC3(O)CCC3)c12)-c1ccc(cc1-c1ccc(C#N)c(F)c1)C(=O)N1C2CCC1CC(N)C2 |THB:41:40:36.37:34| Show InChI InChI=1S/C33H32F2N6O2/c1-18-30(35)27(15-29-31(18)40(39-38-29)17-33(43)9-2-10-33)25-8-5-20(11-26(25)19-3-4-21(16-36)28(34)12-19)32(42)41-23-6-7-24(41)14-22(37)13-23/h3-5,8,11-12,15,22-24,43H,2,6-7,9-10,13-14,17,37H2,1H3	PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	0.140	n/a	n/a	n/a	n/a	n/a	n/a
Taiho Pharmaceutical Co., Ltd. US Patent					Assay Description The conditions for measuring inhibitory activity of compounds against LSD1 activity were determined with reference to a document available from the w...				US Patent US10723742 (2020)
					More data for this Ligand-Target Pair