BDBM458528 2-{2-[4-(1,2-Benzoisothiazol-3-yl)piperazin-1-yl]ethyl}-6-methoxy-3,4-dihydro-2,7-naphthyridin-1(2H)-one::US10745401, Example 107::US10745401, Example 2
SMILES: COc1cc2CCN(CCN3CCN(CC3)c3nsc4ccccc34)C(=O)c2cn1
InChI Key: InChIKey=FOQOXYFYHFUCMT-UHFFFAOYSA-N
Data: 6 KI
Target/Host (Institution) | Ligand | Target/Host Links | Ligand Links | Trg + Lig Links | Ki nM | ΔG° kcal/mole | IC50 nM | Kd nM | EC50/IC50 nM | koff s-1 | kon M-1s-1 | pH | Temp °C |
---|---|---|---|---|---|---|---|---|---|---|---|---|---|
5-hydroxytryptamine receptor 1A (Homo sapiens (Human)) | BDBM458528 (2-{2-[4-(1,2-Benzoisothiazol-3-yl)piperazin-1-yl]e...) | PDB UniProtKB/SwissProt UniProtKB/TrEMBL antibodypedia GoogleScholar AffyNet | PC cid PC sid UniChem | US Patent | 0.0300 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
SUMITOMO DAINIPPON PHARMA CO., LTD. US Patent | Assay Description Binding affinity of the present compound for human 5-HT1A receptor, human 5-HT2A receptor, and human D2 receptor was measured by the following proced... | US Patent US10745401 (2020) | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
5-hydroxytryptamine receptor 1A (Homo sapiens (Human)) | BDBM458528 (2-{2-[4-(1,2-Benzoisothiazol-3-yl)piperazin-1-yl]e...) | PDB UniProtKB/SwissProt UniProtKB/TrEMBL antibodypedia GoogleScholar AffyNet | PC cid PC sid UniChem | US Patent | 0.0800 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
SUMITOMO DAINIPPON PHARMA CO., LTD. US Patent | Assay Description Binding affinity of the present compound for human 5-HT1A receptor, human 5-HT2A receptor, and human D2 receptor was measured by the following proced... | US Patent US10745401 (2020) | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
5-hydroxytryptamine receptor 2A (Homo sapiens (Human)) | BDBM458528 (2-{2-[4-(1,2-Benzoisothiazol-3-yl)piperazin-1-yl]e...) | PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet | PC cid PC sid UniChem | US Patent | 0.400 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
SUMITOMO DAINIPPON PHARMA CO., LTD. US Patent | Assay Description Binding affinity of the present compound for human 5-HT1A receptor, human 5-HT2A receptor, and human D2 receptor was measured by the following proced... | US Patent US10745401 (2020) | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
5-hydroxytryptamine receptor 2A (Homo sapiens (Human)) | BDBM458528 (2-{2-[4-(1,2-Benzoisothiazol-3-yl)piperazin-1-yl]e...) | PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet | PC cid PC sid UniChem | US Patent | 0.460 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
SUMITOMO DAINIPPON PHARMA CO., LTD. US Patent | Assay Description Binding affinity of the present compound for human 5-HT1A receptor, human 5-HT2A receptor, and human D2 receptor was measured by the following proced... | US Patent US10745401 (2020) | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
D(2) dopamine receptor (Homo sapiens (Human)) | BDBM458528 (2-{2-[4-(1,2-Benzoisothiazol-3-yl)piperazin-1-yl]e...) | PDB Reactome pathway KEGG UniProtKB/SwissProt UniProtKB/TrEMBL DrugBank antibodypedia GoogleScholar AffyNet | PC cid PC sid UniChem | US Patent | 128 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
SUMITOMO DAINIPPON PHARMA CO., LTD. US Patent | Assay Description Binding affinity of the present compound for human 5-HT1A receptor, human 5-HT2A receptor, and human D2 receptor was measured by the following proced... | US Patent US10745401 (2020) | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
D(2) dopamine receptor (Homo sapiens (Human)) | BDBM458528 (2-{2-[4-(1,2-Benzoisothiazol-3-yl)piperazin-1-yl]e...) | PDB Reactome pathway KEGG UniProtKB/SwissProt UniProtKB/TrEMBL DrugBank antibodypedia GoogleScholar AffyNet | PC cid PC sid UniChem | US Patent | 244 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
SUMITOMO DAINIPPON PHARMA CO., LTD. US Patent | Assay Description Binding affinity of the present compound for human 5-HT1A receptor, human 5-HT2A receptor, and human D2 receptor was measured by the following proced... | US Patent US10745401 (2020) | |||||||||||
More data for this Ligand-Target Pair |