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SMILES: O[C@H](C[C@@H](Cc1ccc(cc1)-c1cccc(Cl)c1)NC(=O)c1ccc(O)nn1)C(O)=O

InChI Key: InChIKey=SOSDALHHUDBXIO-IEBWSBKVSA-N

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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 1 hit for monomerid = 459408   
Target/Host
(Institution)		LigandTarget/Host
Links		Ligand
Links		Trg + Lig
Links		Ki
nM		ΔG°
kcal/mole		IC50
nM		Kd
nM		EC50/IC50
nM		koff
s-1		kon
M-1s-1		pHTemp
°C
Neprilysin


(Homo sapiens (Human))		BDBM459408
PNG
(US10759813, Example 18-50)
Show SMILES O[C@H](C[C@@H](Cc1ccc(cc1)-c1cccc(Cl)c1)NC(=O)c1ccc(O)nn1)C(O)=O
Show InChI InChI=1S/C22H20ClN3O5/c23-16-3-1-2-15(11-16)14-6-4-13(5-7-14)10-17(12-19(27)22(30)31)24-21(29)18-8-9-20(28)26-25-18/h1-9,11,17,19,27H,10,12H2,(H,24,29)(H,26,28)(H,30,31)/t17-,19-/m1/s1
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KEGG

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US Patent
<1n/an/an/an/an/an/an/an/a



Theravance Biopharma R&D IP, LLC

US Patent


Assay Description
The assays were performed in 384-well white opaque plates at 37° C. using the fluorogenic peptide substrates at a concentration of 10 μM in Assa...

US Patent US10759813 (2020)

More data for this
Ligand-Target Pair