BDBM46100 6-hydroxy-2,4-diketo-N-phenyl-1H-pyrimidine-5-carboxamide::6-hydroxy-2,4-dioxo-N-phenyl-1H-pyrimidine-5-carboxamide::6-oxidanyl-2,4-bis(oxidanylidene)-N-phenyl-1H-pyrimidine-5-carboxamide::UPDDI-00294852::US9428466, 2-oxo-desthiomerbarone::cid_100782

SMILES: Oc1[nH]c(=O)[nH]c(=O)c1C(=O)Nc1ccccc1

InChI Key: InChIKey=VKWYRWQIBQMDFJ-UHFFFAOYSA-N

Data: 3 IC50

Find this compound or compounds like it in BindingDB or PDB:

Substructure Similarity at least:  must be >=0.5 Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 3 hits for monomerid = 46100   

Target/Host (Institution)	Ligand	Target/Host Links	Ligand Links	Trg + Lig Links	Ki nM	ΔG° kcal/mole	IC50 nM	Kd nM	EC50/IC50 nM	koff s-1	kon M-1s-1	pH	Temp °C
Serine/threonine-protein kinase PLK1 (Homo sapiens (Human))	BDBM46100 (6-hydroxy-2,4-diketo-N-phenyl-1H-pyrimidine-5-carb...) Show SMILES Oc1[nH]c(=O)[nH]c(=O)c1C(=O)Nc1ccccc1 Show InChI InChI=1S/C11H9N3O4/c15-8(12-6-4-2-1-3-5-6)7-9(16)13-11(18)14-10(7)17/h1-5H,(H,12,15)(H3,13,14,16,17,18)	PDB MMDB NCI pathway Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem Patents Similars	PCBioAssay	n/a	n/a	>5.00E+4	n/a	n/a	n/a	n/a	n/a	n/a
University of Pittsburgh Molecular Library Screening Center Curated by PubChem BioAssay					Assay Description List of compounds to be tested: 33 component starting materials and chemical analogs of the hits identified in the in vitro PLK1-PBD binding primary ...				PubChem Bioassay (2008) BindingDB Entry DOI: 10.7270/Q280511V
					More data for this Ligand-Target Pair
Xanthine dehydrogenase/oxidase (Homo sapiens (Human))	BDBM46100 (6-hydroxy-2,4-diketo-N-phenyl-1H-pyrimidine-5-carb...) Show SMILES Oc1[nH]c(=O)[nH]c(=O)c1C(=O)Nc1ccccc1 Show InChI InChI=1S/C11H9N3O4/c15-8(12-6-4-2-1-3-5-6)7-9(16)13-11(18)14-10(7)17/h1-5H,(H,12,15)(H3,13,14,16,17,18)	PDB MMDB KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem Patents Similars	US Patent	n/a	n/a	>3.00E+5	n/a	n/a	n/a	n/a	n/a	n/a
TBA US Patent					Assay Description Xanthine oxidase inhibition was determined using a standard fluorescence-based assay for xanthine oxidase activity (McHale A, Grimes H, Coughlan M P:...				US Patent US9428466 (2016) BindingDB Entry DOI: 10.7270/Q22J69RM
					More data for this Ligand-Target Pair
Solute carrier family 22 member 12 (Homo sapiens (Human))	BDBM46100 (6-hydroxy-2,4-diketo-N-phenyl-1H-pyrimidine-5-carb...) Show SMILES Oc1[nH]c(=O)[nH]c(=O)c1C(=O)Nc1ccccc1 Show InChI InChI=1S/C11H9N3O4/c15-8(12-6-4-2-1-3-5-6)7-9(16)13-11(18)14-10(7)17/h1-5H,(H,12,15)(H3,13,14,16,17,18)	KEGG UniProtKB/SwissProt DrugBank antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem Patents Similars	US Patent	n/a	n/a	1.20E+3	n/a	n/a	n/a	n/a	n/a	n/a
TBA US Patent					Assay Description URAT1 (SLC22A12) activity was evaluated in a cellular uptake assay using a 96-well plate with stably transfected URAT-1/CHO cells. 3H-orotate was use...				US Patent US9428466 (2016) BindingDB Entry DOI: 10.7270/Q22J69RM
					More data for this Ligand-Target Pair